Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development.

Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development.

Alternative splicing amplifies the information content of the genome, creating multiple mRNA isoforms from single genes. The evolutionarily conserved splicing activator Tra2β (Sfrs10) is essential for mouse embryogenesis and implicated in spermatogenesis. Here we find that Tra2β is up-regulated as t...

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Bibliographic Details
Main Authors: Sushma Grellscheid, Caroline Dalgliesh, Markus Storbeck, Andrew Best, Yilei Liu, Miriam Jakubik, Ylva Mende, Ingrid Ehrmann, Tomaz Curk, Kristina Rossbach, Cyril F Bourgeois, James Stévenin, David Grellscheid, Michael S Jackson, Brunhilde Wirth, David J Elliott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3240583?pdf=render

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