Molecular noise filtering in the β-adrenergic signaling network by phospholamban pentamers

Molecular noise filtering in the β-adrenergic signaling network by phospholamban pentamers

Summary: Phospholamban (PLN) is an important regulator of cardiac calcium handling due to its ability to inhibit the calcium ATPase SERCA. β-Adrenergic stimulation reverses SERCA inhibition via PLN phosphorylation and facilitates fast calcium reuptake. PLN also forms pentamers whose physiological si...

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Bibliographic Details
Main Authors: Daniel Koch, Alexander Alexandrovich, Florian Funk, Ay Lin Kho, Joachim P. Schmitt, Mathias Gautel
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
systems biology
oligomerization
phosphorylation
signaling networks
cardiomyocytes
calcium handling
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721008652

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