Life-long Maternal Cafeteria Diet Promotes Tissue-Specific Morphological Changes in Male Offspring Adult Rats
ABSTRACT Here, we evaluated whether the exposure of rats to a cafeteria diet pre- and/or post-weaning, alters histological characteristics in the White Adipose Tissue (WAT), Brown Adipose Tissue (BAT), and liver of adult male offspring. Female Wistar rats were divided into Control (CTL; fed on stand...
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Academia Brasileira de Ciências
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602887&lng=en&tlng=en |
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| author | CAROLYNE D.S. SANTOS SANDRA L. BALBO ANA T.B. GUIMARÃES SARA C. SAGAE FÁBIO NEGRETTI SABRINA GRASSIOLLI |
| author_facet | CAROLYNE D.S. SANTOS SANDRA L. BALBO ANA T.B. GUIMARÃES SARA C. SAGAE FÁBIO NEGRETTI SABRINA GRASSIOLLI |
| author_sort | CAROLYNE D.S. SANTOS |
| collection | DOAJ |
| description | ABSTRACT Here, we evaluated whether the exposure of rats to a cafeteria diet pre- and/or post-weaning, alters histological characteristics in the White Adipose Tissue (WAT), Brown Adipose Tissue (BAT), and liver of adult male offspring. Female Wistar rats were divided into Control (CTL; fed on standard rodent chow) and Cafeteria (CAF; fed with the cafeteria diet throughout life, including pregnancy and lactation). After birth, only male offspring (F1) were maintained and received the CTL or CAF diets; originating four experimental groups: CTL-CTLF1; CTL-CAFF1; CAF-CTLF1; CAF-CAFF1. Data of biometrics, metabolic parameters, liver, BAT and WAT histology were assessed and integrated using the Principal Component Analysis (PCA). According to PCA analysis worse metabolic and biometric characteristics in adulthood are associated with the post-weaning CAF diet compared to pre and post weaning CAF diet. Thus, the CTL-CAFF1 group showed obesity, higher deposition of fat in the liver and BAT and high fasting plasma levels of glucose, triglycerides and cholesterol. Interestingly, the association between pre and post-weaning CAF diet attenuated the obesity and improved the plasma levels of glucose and triglycerides compared to CTL-CAFF1 without avoiding the higher lipid accumulation in BAT and in liver, suggesting that the impact of maternal CAF diet is tissue-specific. |
| first_indexed | 2024-04-13T14:20:35Z |
| format | Article |
| id | doaj.art-20c68b9004074f288e59ccbc501661dd |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-04-13T14:20:35Z |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-20c68b9004074f288e59ccbc501661dd2022-12-22T02:43:30ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26908942887290010.1590/0001-3765201720170316S0001-37652017000602887Life-long Maternal Cafeteria Diet Promotes Tissue-Specific Morphological Changes in Male Offspring Adult RatsCAROLYNE D.S. SANTOSSANDRA L. BALBOANA T.B. GUIMARÃESSARA C. SAGAEFÁBIO NEGRETTISABRINA GRASSIOLLIABSTRACT Here, we evaluated whether the exposure of rats to a cafeteria diet pre- and/or post-weaning, alters histological characteristics in the White Adipose Tissue (WAT), Brown Adipose Tissue (BAT), and liver of adult male offspring. Female Wistar rats were divided into Control (CTL; fed on standard rodent chow) and Cafeteria (CAF; fed with the cafeteria diet throughout life, including pregnancy and lactation). After birth, only male offspring (F1) were maintained and received the CTL or CAF diets; originating four experimental groups: CTL-CTLF1; CTL-CAFF1; CAF-CTLF1; CAF-CAFF1. Data of biometrics, metabolic parameters, liver, BAT and WAT histology were assessed and integrated using the Principal Component Analysis (PCA). According to PCA analysis worse metabolic and biometric characteristics in adulthood are associated with the post-weaning CAF diet compared to pre and post weaning CAF diet. Thus, the CTL-CAFF1 group showed obesity, higher deposition of fat in the liver and BAT and high fasting plasma levels of glucose, triglycerides and cholesterol. Interestingly, the association between pre and post-weaning CAF diet attenuated the obesity and improved the plasma levels of glucose and triglycerides compared to CTL-CAFF1 without avoiding the higher lipid accumulation in BAT and in liver, suggesting that the impact of maternal CAF diet is tissue-specific.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602887&lng=en&tlng=enobesitydamsoffspringhistology |
| spellingShingle | CAROLYNE D.S. SANTOS SANDRA L. BALBO ANA T.B. GUIMARÃES SARA C. SAGAE FÁBIO NEGRETTI SABRINA GRASSIOLLI Life-long Maternal Cafeteria Diet Promotes Tissue-Specific Morphological Changes in Male Offspring Adult Rats Anais da Academia Brasileira de Ciências obesity dams offspring histology |
| title | Life-long Maternal Cafeteria Diet Promotes Tissue-Specific Morphological Changes in Male Offspring Adult Rats |
| title_full | Life-long Maternal Cafeteria Diet Promotes Tissue-Specific Morphological Changes in Male Offspring Adult Rats |
| title_fullStr | Life-long Maternal Cafeteria Diet Promotes Tissue-Specific Morphological Changes in Male Offspring Adult Rats |
| title_full_unstemmed | Life-long Maternal Cafeteria Diet Promotes Tissue-Specific Morphological Changes in Male Offspring Adult Rats |
| title_short | Life-long Maternal Cafeteria Diet Promotes Tissue-Specific Morphological Changes in Male Offspring Adult Rats |
| title_sort | life long maternal cafeteria diet promotes tissue specific morphological changes in male offspring adult rats |
| topic | obesity dams offspring histology |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602887&lng=en&tlng=en |
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