Scoparone attenuates cholestatic liver injury through regulating hepatic bile acid metabolism, ameliorating periductal fibrosis and inhibiting inflammatory response

Scoparone attenuates cholestatic liver injury through regulating hepatic bile acid metabolism, ameliorating periductal fibrosis and inhibiting inflammatory response

Background: Cholestatic liver disease (CLD) encompasses a broad spectrum of etiologically heterogeneous hepatobiliary disorders with common features, including ductal reaction, periductal fibrosis, and inflammatory response. Scoparone (SCO) is a bioactive component of the herbal medicine Artemisia c...

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Bibliographic Details
Main Authors: Juan Hao, Xiaoyu Shen, Kan Lu, Yi Xu, Yiyue Chen, Jibo Liu, Xiaohong Shao, Chunling Zhu, Yaqin Ding, Xin Xie, Jian Wu, Quanjun Yang
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Pharmacological Research - Modern Chinese Medicine
Subjects:
Cholestasis
Scoparone
Bile acids
Inflammatory
Periductal fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2667142523000787

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