Study Protocol of Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro)
BackgroundThe ongoing Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro) aims to observe the natural course of papillary thyroid microcarcinoma (PTMC), develop a protocol for active surveillance (AS), and compare the long-term prognosis, quality...
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2018-06-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-33-278.pdf |
| _version_ | 1811331878221774848 |
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| author | Jae Hoon Moon Ji-hoon Kim Eun Kyung Lee Kyu Eun Lee Sung Hye Kong Yeo Koon Kim Woo-jin Jung Chang Yoon Lee Roh-Eul Yoo Yul Hwangbo Young Shin Song Min Joo Kim Sun Wook Cho Su-jin Kim Eun Jae Jung June Young Choi Chang Hwan Ryu You Jin Lee Jeong Hun Hah Yuh-Seog Jung Junsun Ryu Yunji Hwang Sue K. Park Ho Kyung Sung Ka Hee Yi Do Joon Park Young Joo Park |
| author_facet | Jae Hoon Moon Ji-hoon Kim Eun Kyung Lee Kyu Eun Lee Sung Hye Kong Yeo Koon Kim Woo-jin Jung Chang Yoon Lee Roh-Eul Yoo Yul Hwangbo Young Shin Song Min Joo Kim Sun Wook Cho Su-jin Kim Eun Jae Jung June Young Choi Chang Hwan Ryu You Jin Lee Jeong Hun Hah Yuh-Seog Jung Junsun Ryu Yunji Hwang Sue K. Park Ho Kyung Sung Ka Hee Yi Do Joon Park Young Joo Park |
| author_sort | Jae Hoon Moon |
| collection | DOAJ |
| description | BackgroundThe ongoing Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro) aims to observe the natural course of papillary thyroid microcarcinoma (PTMC), develop a protocol for active surveillance (AS), and compare the long-term prognosis, quality of life, and medical costs between the AS and immediate surgery groups.MethodsThis multicenter prospective cohort study of PTMC started in June 2016. The inclusion criteria were suspicious of malignancy or malignancy based on fine needle aspiration or core needle biopsy, age of ≥18 years, and a maximum diameter of ≤1 cm. If there was no major organ involvement, no lymph node/distant metastasis, and no variants with poor prognosis, the patients were explained of the pros and cons of immediate surgery and AS before selecting AS or immediate surgery. Follow-up visits (physical examination, ultrasonography, thyroid function, and questionnaires) are scheduled every 6 months during the first 2 years, and then every 1 year thereafter. Progression was defined as a maximum diameter increase of ≥3, ≥2 mm in two dimensions, suspected organ involvement, or lymph node/distant metastasis.ResultsAmong 439 enrolled patients, 290 patients (66.1%) chose AS and 149 patients (33.9%) chose immediate surgery. The median follow-up was 6.7 months (range, 0.2 to 11.9). The immediate surgery group had a larger maximum tumor diameter, compared to the AS group (7.1±1.9 mm vs. 6.6±2.0 mm, respectively; P=0.014).ConclusionThe results will be useful for developing an appropriate PTMC treatment policy based on its natural course and risk factors for progression. |
| first_indexed | 2024-04-13T16:27:26Z |
| format | Article |
| id | doaj.art-20c8a97d27ad4836803e764154540832 |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-04-13T16:27:26Z |
| publishDate | 2018-06-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-20c8a97d27ad4836803e7641545408322022-12-22T02:39:42ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782018-06-0133227828610.3803/EnM.2018.33.2.278Study Protocol of Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro)Jae Hoon Moon0Ji-hoon Kim1Eun Kyung Lee2Kyu Eun Lee3Sung Hye Kong4Yeo Koon Kim5Woo-jin Jung6Chang Yoon Lee7Roh-Eul Yoo8Yul Hwangbo9Young Shin Song10Min Joo Kim11Sun Wook Cho12Su-jin Kim13Eun Jae Jung14June Young Choi15Chang Hwan Ryu16You Jin Lee17Jeong Hun Hah18Yuh-Seog Jung19Junsun Ryu20Yunji Hwang21Sue K. Park22Ho Kyung Sung23Ka Hee Yi24Do Joon Park25Young Joo Park26Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, .KoreaDepartment of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Internal Medicine, National Cancer Center, Goyang, .KoreaDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, .KoreaDepartment of Otorhinolaryngology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, .KoreaDepartment of Radiology, National Cancer Center, Goyang, .KoreaDepartment of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Internal Medicine, National Cancer Center, Goyang, .KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Otorhinolaryngology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, .KoreaDepartment of Otorhinolaryngology, National Cancer Center, Goyang, .KoreaDepartment of Internal Medicine, National Cancer Center, Goyang, .KoreaDepartment of Otorhinolaryngology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Otorhinolaryngology, National Cancer Center, Goyang, .KoreaDepartment of Otorhinolaryngology, National Cancer Center, Goyang, .KoreaDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, .KoreaBackgroundThe ongoing Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro) aims to observe the natural course of papillary thyroid microcarcinoma (PTMC), develop a protocol for active surveillance (AS), and compare the long-term prognosis, quality of life, and medical costs between the AS and immediate surgery groups.MethodsThis multicenter prospective cohort study of PTMC started in June 2016. The inclusion criteria were suspicious of malignancy or malignancy based on fine needle aspiration or core needle biopsy, age of ≥18 years, and a maximum diameter of ≤1 cm. If there was no major organ involvement, no lymph node/distant metastasis, and no variants with poor prognosis, the patients were explained of the pros and cons of immediate surgery and AS before selecting AS or immediate surgery. Follow-up visits (physical examination, ultrasonography, thyroid function, and questionnaires) are scheduled every 6 months during the first 2 years, and then every 1 year thereafter. Progression was defined as a maximum diameter increase of ≥3, ≥2 mm in two dimensions, suspected organ involvement, or lymph node/distant metastasis.ResultsAmong 439 enrolled patients, 290 patients (66.1%) chose AS and 149 patients (33.9%) chose immediate surgery. The median follow-up was 6.7 months (range, 0.2 to 11.9). The immediate surgery group had a larger maximum tumor diameter, compared to the AS group (7.1±1.9 mm vs. 6.6±2.0 mm, respectively; P=0.014).ConclusionThe results will be useful for developing an appropriate PTMC treatment policy based on its natural course and risk factors for progression.https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-33-278.pdfThyroid neoplasmsActive surveillanceProspective cohortPapillary thyroid microcarcinoma |
| spellingShingle | Jae Hoon Moon Ji-hoon Kim Eun Kyung Lee Kyu Eun Lee Sung Hye Kong Yeo Koon Kim Woo-jin Jung Chang Yoon Lee Roh-Eul Yoo Yul Hwangbo Young Shin Song Min Joo Kim Sun Wook Cho Su-jin Kim Eun Jae Jung June Young Choi Chang Hwan Ryu You Jin Lee Jeong Hun Hah Yuh-Seog Jung Junsun Ryu Yunji Hwang Sue K. Park Ho Kyung Sung Ka Hee Yi Do Joon Park Young Joo Park Study Protocol of Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro) Endocrinology and Metabolism Thyroid neoplasms Active surveillance Prospective cohort Papillary thyroid microcarcinoma |
| title | Study Protocol of Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro) |
| title_full | Study Protocol of Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro) |
| title_fullStr | Study Protocol of Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro) |
| title_full_unstemmed | Study Protocol of Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro) |
| title_short | Study Protocol of Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro) |
| title_sort | study protocol of multicenter prospective cohort study of active surveillance on papillary thyroid microcarcinoma maestro |
| topic | Thyroid neoplasms Active surveillance Prospective cohort Papillary thyroid microcarcinoma |
| url | https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-33-278.pdf |
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