The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface
A video-oculographic interface is a system for controlling objects using eye movements. The video-oculographic interface differs from other brain-computer interfaces regarding its improved accuracy, simplicity, and ergonomics. Despite these advantages, all users are not equally successful in mast...
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| Format: | Article |
| Language: | English |
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IMR Press
2021-06-01
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| Series: | Journal of Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://jin.imrpress.com/fileup/1757-448X/PDF/1625014727596-1974629408.pdf |
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| author | Yaroslav A. Turovsky Artem P. Gureev Inna Yu. Vitkalova Vasily N. Popov Alexey A. Vakhtin |
| author_facet | Yaroslav A. Turovsky Artem P. Gureev Inna Yu. Vitkalova Vasily N. Popov Alexey A. Vakhtin |
| author_sort | Yaroslav A. Turovsky |
| collection | DOAJ |
| description | A video-oculographic interface is a system for controlling objects using eye
movements. The video-oculographic interface differs from other brain-computer interfaces regarding its
improved accuracy, simplicity, and ergonomics. Despite these advantages, all
users are not equally successful in mastering these various devices. It has been
suggested that the genetic characteristics of the operators may determine the
efficiency of video-oculographic interface mastery. We recruited healthy users with rs6313, rs2030324,
rs429358, rs10119, rs457062, rs4290270, and rs6265 polymorphisms and analyzed the
relationships between these polymorphisms and values of success in video-oculographic interface mastery.
We found that carriers of the G/G genotype of the rs6265 polymorphism
(BDNF gene) demonstrated the best results in video-oculographic interface mastery. In contrast,
carriers of the A/A genotype were characterized by large standard deviations in
the average amplitude of eye movement and the range of eye movement negatively
correlated with goal achievement. This can be explained through the fact that
carriers of the A/A genotype demonstrate lower synaptic plasticity due to reduced
expression of BDNF when compared to carriers of the G/G genotype. These
results expand our understanding of the genetic predictors of successful video-oculographic interface
management, which will help to optimize device management training for equipment
operators and people with disabilities. |
| first_indexed | 2024-12-11T21:26:29Z |
| format | Article |
| id | doaj.art-20c8d715a3454b9aba39ac410c7406f8 |
| institution | Directory Open Access Journal |
| issn | 1757-448X |
| language | English |
| last_indexed | 2024-12-11T21:26:29Z |
| publishDate | 2021-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-20c8d715a3454b9aba39ac410c7406f82022-12-22T00:50:18ZengIMR PressJournal of Integrative Neuroscience1757-448X2021-06-0120228729610.31083/j.jin20020281625014727596-1974629408The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interfaceYaroslav A. Turovsky0Artem P. Gureev1Inna Yu. Vitkalova2Vasily N. Popov3Alexey A. Vakhtin4Laboratory of Medical Cybernetics, Voronezh State University, 394018 Voronezh, RussiaDepartment of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, RussiaDepartment of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, RussiaDepartment of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, RussiaDepartment of Programming and Information Technologies, Voronezh State University, 394018 Voronezh, RussiaA video-oculographic interface is a system for controlling objects using eye movements. The video-oculographic interface differs from other brain-computer interfaces regarding its improved accuracy, simplicity, and ergonomics. Despite these advantages, all users are not equally successful in mastering these various devices. It has been suggested that the genetic characteristics of the operators may determine the efficiency of video-oculographic interface mastery. We recruited healthy users with rs6313, rs2030324, rs429358, rs10119, rs457062, rs4290270, and rs6265 polymorphisms and analyzed the relationships between these polymorphisms and values of success in video-oculographic interface mastery. We found that carriers of the G/G genotype of the rs6265 polymorphism (BDNF gene) demonstrated the best results in video-oculographic interface mastery. In contrast, carriers of the A/A genotype were characterized by large standard deviations in the average amplitude of eye movement and the range of eye movement negatively correlated with goal achievement. This can be explained through the fact that carriers of the A/A genotype demonstrate lower synaptic plasticity due to reduced expression of BDNF when compared to carriers of the G/G genotype. These results expand our understanding of the genetic predictors of successful video-oculographic interface management, which will help to optimize device management training for equipment operators and people with disabilities.https://jin.imrpress.com/fileup/1757-448X/PDF/1625014727596-1974629408.pdfvideo-oculographic interfacebrain-derived neurotrophic factorrs6265eye movementworking memory |
| spellingShingle | Yaroslav A. Turovsky Artem P. Gureev Inna Yu. Vitkalova Vasily N. Popov Alexey A. Vakhtin The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface Journal of Integrative Neuroscience video-oculographic interface brain-derived neurotrophic factor rs6265 eye movement working memory |
| title | The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface |
| title_full | The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface |
| title_fullStr | The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface |
| title_full_unstemmed | The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface |
| title_short | The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface |
| title_sort | connection between rs6265 polymorphism in the bdnf gene and successful mastering of the video oculographic interface |
| topic | video-oculographic interface brain-derived neurotrophic factor rs6265 eye movement working memory |
| url | https://jin.imrpress.com/fileup/1757-448X/PDF/1625014727596-1974629408.pdf |
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