The impact of brominated flame retardants (BFRs) on pulmonary function in US adults: a cross-sectional study based on NHANES (2007–2012)
Abstract Brominated flame retardants (BFRs) are a group of chemicals widely used in various applications to prevent or slow down the spread of fire. However, they have adverse effects on human health. There is a relative scarcity of population-based studies regarding BFRs, particularly their impact...
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| Format: | Article |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-57302-9 |
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| author | Haiyan Mao Tong Lin Shanshan Huang Zhenye Xie Shaofeng Jin Xingkai Shen Yuhong Jin Yi Ding |
| author_facet | Haiyan Mao Tong Lin Shanshan Huang Zhenye Xie Shaofeng Jin Xingkai Shen Yuhong Jin Yi Ding |
| author_sort | Haiyan Mao |
| collection | DOAJ |
| description | Abstract Brominated flame retardants (BFRs) are a group of chemicals widely used in various applications to prevent or slow down the spread of fire. However, they have adverse effects on human health. There is a relative scarcity of population-based studies regarding BFRs, particularly their impact on the respiratory system. This study aimed to investigate the influence of BFRs on pulmonary function using data from the National Health and Nutrition Examination Survey. The study found that elevated serum concentrations of certain BFRs were associated with pulmonary ventilatory dysfunction. Adjusted analyses revealed positive correlations between PBDE47, PBDE183, and PBDE209 concentrations and ventilatory dysfunction. The analysis of mixed BFRs showed a positive relationship with pulmonary ventilation dysfunction, with PBDE47 making the most significant contribution. Our study demonstrates that both individual and combined BFRs exposure can lead to impaired pulmonary ventilation function. These findings provide evidence of the adverse effects of BFRs on lung function, emphasizing the importance of further investigating the potential health consequences of these compounds. Further large-scale longitudinal studies are needed to investigate this relationship in the future. |
| first_indexed | 2024-04-24T19:55:42Z |
| format | Article |
| id | doaj.art-20c9ae8b6da443d5bba4f01ede06d4cb |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T19:55:42Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-20c9ae8b6da443d5bba4f01ede06d4cb2024-03-24T12:19:31ZengNature PortfolioScientific Reports2045-23222024-03-0114111110.1038/s41598-024-57302-9The impact of brominated flame retardants (BFRs) on pulmonary function in US adults: a cross-sectional study based on NHANES (2007–2012)Haiyan Mao0Tong Lin1Shanshan Huang2Zhenye Xie3Shaofeng Jin4Xingkai Shen5Yuhong Jin6Yi Ding7Department of Critical Care Medicine, Ningbo Medical Center Lihuili HospitalDepartment of Critical Care Medicine, Ningbo Medical Center Lihuili HospitalDepartment of Critical Care Medicine, Ningbo Medical Center Lihuili HospitalDepartment of Critical Care Medicine, Ningbo Medical Center Lihuili HospitalDepartment of Critical Care Medicine, Ningbo Medical Center Lihuili HospitalDepartment of Critical Care Medicine, Ningbo Medical Center Lihuili HospitalDepartment of Critical Care Medicine, Ningbo Medical Center Lihuili HospitalDepartment of Critical Care Medicine, Ningbo Medical Center Lihuili HospitalAbstract Brominated flame retardants (BFRs) are a group of chemicals widely used in various applications to prevent or slow down the spread of fire. However, they have adverse effects on human health. There is a relative scarcity of population-based studies regarding BFRs, particularly their impact on the respiratory system. This study aimed to investigate the influence of BFRs on pulmonary function using data from the National Health and Nutrition Examination Survey. The study found that elevated serum concentrations of certain BFRs were associated with pulmonary ventilatory dysfunction. Adjusted analyses revealed positive correlations between PBDE47, PBDE183, and PBDE209 concentrations and ventilatory dysfunction. The analysis of mixed BFRs showed a positive relationship with pulmonary ventilation dysfunction, with PBDE47 making the most significant contribution. Our study demonstrates that both individual and combined BFRs exposure can lead to impaired pulmonary ventilation function. These findings provide evidence of the adverse effects of BFRs on lung function, emphasizing the importance of further investigating the potential health consequences of these compounds. Further large-scale longitudinal studies are needed to investigate this relationship in the future.https://doi.org/10.1038/s41598-024-57302-9Brominated flame retardantsPulmonary functionVentilatory dysfunctionCross-sectional study |
| spellingShingle | Haiyan Mao Tong Lin Shanshan Huang Zhenye Xie Shaofeng Jin Xingkai Shen Yuhong Jin Yi Ding The impact of brominated flame retardants (BFRs) on pulmonary function in US adults: a cross-sectional study based on NHANES (2007–2012) Scientific Reports Brominated flame retardants Pulmonary function Ventilatory dysfunction Cross-sectional study |
| title | The impact of brominated flame retardants (BFRs) on pulmonary function in US adults: a cross-sectional study based on NHANES (2007–2012) |
| title_full | The impact of brominated flame retardants (BFRs) on pulmonary function in US adults: a cross-sectional study based on NHANES (2007–2012) |
| title_fullStr | The impact of brominated flame retardants (BFRs) on pulmonary function in US adults: a cross-sectional study based on NHANES (2007–2012) |
| title_full_unstemmed | The impact of brominated flame retardants (BFRs) on pulmonary function in US adults: a cross-sectional study based on NHANES (2007–2012) |
| title_short | The impact of brominated flame retardants (BFRs) on pulmonary function in US adults: a cross-sectional study based on NHANES (2007–2012) |
| title_sort | impact of brominated flame retardants bfrs on pulmonary function in us adults a cross sectional study based on nhanes 2007 2012 |
| topic | Brominated flame retardants Pulmonary function Ventilatory dysfunction Cross-sectional study |
| url | https://doi.org/10.1038/s41598-024-57302-9 |
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