A matrisome RNA signature from early-pregnancy mouse mammary fibroblasts predicts distant metastasis-free breast cancer survival in humans

A matrisome RNA signature from early-pregnancy mouse mammary fibroblasts predicts distant metastasis-free breast cancer survival in humans

Abstract Background During pregnancy, the mouse mammary ductal epithelium branches and grows into the surrounding stroma, requiring extensive extracellular matrix (ECM) and tissue remodelling. It therefore shows parallels to cancer invasion. We hypothesised that similar molecular mechanisms may be u...

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Bibliographic Details
Main Authors: Ayman M. Ibrahim, Alan Bilsland, Steffen Rickelt, Joanna S. Morris, Torsten Stein
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Breast Cancer Research
Subjects:
Mammary gland
Fibroblasts
Branching
Microarray
Extracellular matrix
Online Access:https://doi.org/10.1186/s13058-021-01470-3

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