Ciprofloxacin and Graphene Oxide Combination—New Face of a Known Drug
Drug modification with nanomaterials is a new trend in pharmaceutical studies and shows promising results, especially considering carbon-based solutions. Graphene and its derivatives have attracted much research interest for their potential applications in biomedical areas as drug modifiers. The fol...
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2020-09-01
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| Online Access: | https://www.mdpi.com/1996-1944/13/19/4224 |
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| author | Karolina Matulewicz Łukasz Kaźmierski Marek Wiśniewski Szymon Roszkowski Krzysztof Roszkowski Oliwia Kowalczyk Archi Roy Bartosz Tylkowski Anna Bajek |
| author_facet | Karolina Matulewicz Łukasz Kaźmierski Marek Wiśniewski Szymon Roszkowski Krzysztof Roszkowski Oliwia Kowalczyk Archi Roy Bartosz Tylkowski Anna Bajek |
| author_sort | Karolina Matulewicz |
| collection | DOAJ |
| description | Drug modification with nanomaterials is a new trend in pharmaceutical studies and shows promising results, especially considering carbon-based solutions. Graphene and its derivatives have attracted much research interest for their potential applications in biomedical areas as drug modifiers. The following work is a comprehensive study regarding the toxicity of ciprofloxacin (CIP) modified by graphene oxide (GO). The influence on the morphology, viability, cell death pathway and proliferation of T24 and 786-0 cells was studied. The results show that ciprofloxacin modified with graphene oxide (CGO) shows the highest increase in cytotoxic potential, especially in the case of T24 cells. We discovered a clear connection between CIP modification with GO and the increase in its apoptotic potential. Our results show that drug modification with carbon-based nanomaterials might be a promising strategy to improve the qualities of existing drugs. Nevertheless, it is important to remember that cytotoxicity effects are highly dependent on dose and nanomaterial size. It is necessary to conduct further research to determine the optimal dose of GO for drug modification. |
| first_indexed | 2024-03-10T16:07:20Z |
| format | Article |
| id | doaj.art-20cb4511b07f4cbba06fe6dd51afff70 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T16:07:20Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-20cb4511b07f4cbba06fe6dd51afff702023-11-20T14:45:41ZengMDPI AGMaterials1996-19442020-09-011319422410.3390/ma13194224Ciprofloxacin and Graphene Oxide Combination—New Face of a Known DrugKarolina Matulewicz0Łukasz Kaźmierski1Marek Wiśniewski2Szymon Roszkowski3Krzysztof Roszkowski4Oliwia Kowalczyk5Archi Roy6Bartosz Tylkowski7Anna Bajek8Chair of Urology, Department of Tissue Engineering, Collegium Medicum, Nicolaus Copernicus University, Karlowicza str. 24, 85-092 Bydgoszcz, PolandChair of Urology, Department of Tissue Engineering, Collegium Medicum, Nicolaus Copernicus University, Karlowicza str. 24, 85-092 Bydgoszcz, PolandDepartment of Chemistry of Materials Adsorption and Catalysis, Nicolaus Copernicus University, Gagarina str. 7, 87-100 Torun, PolandFaculty of Agronomy and Bioengineering, Poznan of Life Sciences, Wojska Polskiego str. 28, 60-637 Poznan, PolandDepartment of Oncology, Collegium Medicum, Nicolaus Copernicus University, Lukasiewicza str. 1, 85-821 Bydgoszcz, PolandResearch and Education Unit for Communication in Healthcare, Department of Cardiac Surgery, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun, M. Curie Sklodowskiej St. 9, 85-094 Bydgoszcz, PolandDepartament d’Enginyeria Química, Universitat Rovira i Virgili, Avda. Països Catalans, 26. Ed. E4. (C. Sescelades), 43007 Tarragona, SpainEurecat, Centre Tecnològic de Catalunya, C/Marcellí Domingo s/n, 43007 Tarragona, SpainChair of Urology, Department of Tissue Engineering, Collegium Medicum, Nicolaus Copernicus University, Karlowicza str. 24, 85-092 Bydgoszcz, PolandDrug modification with nanomaterials is a new trend in pharmaceutical studies and shows promising results, especially considering carbon-based solutions. Graphene and its derivatives have attracted much research interest for their potential applications in biomedical areas as drug modifiers. The following work is a comprehensive study regarding the toxicity of ciprofloxacin (CIP) modified by graphene oxide (GO). The influence on the morphology, viability, cell death pathway and proliferation of T24 and 786-0 cells was studied. The results show that ciprofloxacin modified with graphene oxide (CGO) shows the highest increase in cytotoxic potential, especially in the case of T24 cells. We discovered a clear connection between CIP modification with GO and the increase in its apoptotic potential. Our results show that drug modification with carbon-based nanomaterials might be a promising strategy to improve the qualities of existing drugs. Nevertheless, it is important to remember that cytotoxicity effects are highly dependent on dose and nanomaterial size. It is necessary to conduct further research to determine the optimal dose of GO for drug modification.https://www.mdpi.com/1996-1944/13/19/4224carbon-based materialsgraphene oxidedrug modification |
| spellingShingle | Karolina Matulewicz Łukasz Kaźmierski Marek Wiśniewski Szymon Roszkowski Krzysztof Roszkowski Oliwia Kowalczyk Archi Roy Bartosz Tylkowski Anna Bajek Ciprofloxacin and Graphene Oxide Combination—New Face of a Known Drug Materials carbon-based materials graphene oxide drug modification |
| title | Ciprofloxacin and Graphene Oxide Combination—New Face of a Known Drug |
| title_full | Ciprofloxacin and Graphene Oxide Combination—New Face of a Known Drug |
| title_fullStr | Ciprofloxacin and Graphene Oxide Combination—New Face of a Known Drug |
| title_full_unstemmed | Ciprofloxacin and Graphene Oxide Combination—New Face of a Known Drug |
| title_short | Ciprofloxacin and Graphene Oxide Combination—New Face of a Known Drug |
| title_sort | ciprofloxacin and graphene oxide combination new face of a known drug |
| topic | carbon-based materials graphene oxide drug modification |
| url | https://www.mdpi.com/1996-1944/13/19/4224 |
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