Metabolic phenotypes and risk of colorectal cancer: a systematic review and meta-analysis of cohort studies
Abstract Background The association of obesity with colorectal cancer (CRC) may vary depending on metabolic status. Objective This meta-analysis aimed to investigate the combined impacts of obesity and metabolic status on CRC risk. Methods The Scopus, PubMed, and web of sciences databases were syste...
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-021-09149-w |
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| author | Golnoosh Goodarzi Hadis Mozaffari Tahereh Raeisi Fatemeh Mehravar Bahman Razi Maryam Lafzi Ghazi Nazila Garousi Shahab Alizadeh Parisa Janmohammadi |
| author_facet | Golnoosh Goodarzi Hadis Mozaffari Tahereh Raeisi Fatemeh Mehravar Bahman Razi Maryam Lafzi Ghazi Nazila Garousi Shahab Alizadeh Parisa Janmohammadi |
| author_sort | Golnoosh Goodarzi |
| collection | DOAJ |
| description | Abstract Background The association of obesity with colorectal cancer (CRC) may vary depending on metabolic status. Objective This meta-analysis aimed to investigate the combined impacts of obesity and metabolic status on CRC risk. Methods The Scopus, PubMed, and web of sciences databases were systematically searched up to Jun 2021 to find all eligible publications examining CRC risk in individuals with metabolically unhealthy normal-weight (MUHNW), metabolically healthy obesity (MHO), and metabolically unhealthy obesity (MUHO) phenotypes. Results A total of 7 cohort studies with a total of 759,066 participants were included in this meta-analysis. Compared with healthy normal-weight people, MUHNW, MHO, and MUHO individuals indicated an increased risk for CRC with a pooled odds ratio of 1.19 (95% CI = 1.09–1.31) in MUHNW, 1.14 (95% CI = 1.06–1.22) in MHO, and 1.24 (95% CI = 1.19–1.29) in MUHO subjects. When analyses were stratified based on gender, associations remained significant for males. However, the elevated risk of CRC associated with MHO and MUHO was not significant in female participants. Conclusions The individuals with metabolic abnormality, although at a normal weight, have an increased risk for CRC. Moreover, obesity is associated with CRC irrespective of metabolic status. |
| first_indexed | 2024-04-11T18:10:34Z |
| format | Article |
| id | doaj.art-20cb7ae2c2d44f0ba2fd9cce903995a5 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-11T18:10:34Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-20cb7ae2c2d44f0ba2fd9cce903995a52022-12-22T04:10:07ZengBMCBMC Cancer1471-24072022-01-0122111410.1186/s12885-021-09149-wMetabolic phenotypes and risk of colorectal cancer: a systematic review and meta-analysis of cohort studiesGolnoosh Goodarzi0Hadis Mozaffari1Tahereh Raeisi2Fatemeh Mehravar3Bahman Razi4Maryam Lafzi Ghazi5Nazila Garousi6Shahab Alizadeh7Parisa Janmohammadi8Department of Nutrition, Science and Research Branch, Islamic Azad UniversityFaculty of Land and Food Systems, University of British ColumbiaDepartment of Medicine, Hormozgan University of Medical SciencesDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences (TUMS)Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares UniversityDepartment of Exercise Physiology, Central Tehran Branch, Islamic Azad UniversityDepartment of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical SciencesDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS)Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS)Abstract Background The association of obesity with colorectal cancer (CRC) may vary depending on metabolic status. Objective This meta-analysis aimed to investigate the combined impacts of obesity and metabolic status on CRC risk. Methods The Scopus, PubMed, and web of sciences databases were systematically searched up to Jun 2021 to find all eligible publications examining CRC risk in individuals with metabolically unhealthy normal-weight (MUHNW), metabolically healthy obesity (MHO), and metabolically unhealthy obesity (MUHO) phenotypes. Results A total of 7 cohort studies with a total of 759,066 participants were included in this meta-analysis. Compared with healthy normal-weight people, MUHNW, MHO, and MUHO individuals indicated an increased risk for CRC with a pooled odds ratio of 1.19 (95% CI = 1.09–1.31) in MUHNW, 1.14 (95% CI = 1.06–1.22) in MHO, and 1.24 (95% CI = 1.19–1.29) in MUHO subjects. When analyses were stratified based on gender, associations remained significant for males. However, the elevated risk of CRC associated with MHO and MUHO was not significant in female participants. Conclusions The individuals with metabolic abnormality, although at a normal weight, have an increased risk for CRC. Moreover, obesity is associated with CRC irrespective of metabolic status.https://doi.org/10.1186/s12885-021-09149-wObesityColorectal cancerPhenotypes |
| spellingShingle | Golnoosh Goodarzi Hadis Mozaffari Tahereh Raeisi Fatemeh Mehravar Bahman Razi Maryam Lafzi Ghazi Nazila Garousi Shahab Alizadeh Parisa Janmohammadi Metabolic phenotypes and risk of colorectal cancer: a systematic review and meta-analysis of cohort studies BMC Cancer Obesity Colorectal cancer Phenotypes |
| title | Metabolic phenotypes and risk of colorectal cancer: a systematic review and meta-analysis of cohort studies |
| title_full | Metabolic phenotypes and risk of colorectal cancer: a systematic review and meta-analysis of cohort studies |
| title_fullStr | Metabolic phenotypes and risk of colorectal cancer: a systematic review and meta-analysis of cohort studies |
| title_full_unstemmed | Metabolic phenotypes and risk of colorectal cancer: a systematic review and meta-analysis of cohort studies |
| title_short | Metabolic phenotypes and risk of colorectal cancer: a systematic review and meta-analysis of cohort studies |
| title_sort | metabolic phenotypes and risk of colorectal cancer a systematic review and meta analysis of cohort studies |
| topic | Obesity Colorectal cancer Phenotypes |
| url | https://doi.org/10.1186/s12885-021-09149-w |
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