The expression level and prognostic value of Y-box binding protein-1 in rectal cancer.
The aims of this study were to simultaneously evaluate the expression of Y-box binding protein-1 (YB-1) in non-neoplastic rectal tissue and rectal cancer tissue, and to collect clinical follow-up data for individual patients. Additionally, we aimed to investigate the developmental functions and prog...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0119385 |
| _version_ | 1819125988934549504 |
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| author | Yu Zhang Ping-Wu Zhao Gang Feng Gang Xie An-Qun Wang Yong-Hong Yang Dong Wang Xiao-Bo Du |
| author_facet | Yu Zhang Ping-Wu Zhao Gang Feng Gang Xie An-Qun Wang Yong-Hong Yang Dong Wang Xiao-Bo Du |
| author_sort | Yu Zhang |
| collection | DOAJ |
| description | The aims of this study were to simultaneously evaluate the expression of Y-box binding protein-1 (YB-1) in non-neoplastic rectal tissue and rectal cancer tissue, and to collect clinical follow-up data for individual patients. Additionally, we aimed to investigate the developmental functions and prognostic value of YB-1 in rectal cancer. We performed immunohistochemical studies to examine YB-1 expression in tissue samples from 80 patients with rectal cancer, 30 patients with rectal tubular adenoma, and 30 patients with rectitis. The mean YB-1 histological scores for rectal cancer, rectal tubular adenoma, and rectitis tissue specimens were 205.5, 164.3, and 137.7, respectively. Shorter disease-free and overall survival times were found in patients with rectal cancer who had higher YB-1 expression than in those with lower expression (38.2 months vs. 52.4 months, P = 0.013; and 44.4 months vs. 57.3 months, P = 0.008, respectively). Our results indicate that YB-1 expression is higher in rectal cancer tissue than in rectal tubular adenoma and rectitis tissue and that it may be an independent prognostic factor for rectal cancer. |
| first_indexed | 2024-12-22T07:48:53Z |
| format | Article |
| id | doaj.art-20cc3ef9882a47b1a5d928725d213896 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T07:48:53Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-20cc3ef9882a47b1a5d928725d2138962022-12-21T18:33:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e011938510.1371/journal.pone.0119385The expression level and prognostic value of Y-box binding protein-1 in rectal cancer.Yu ZhangPing-Wu ZhaoGang FengGang XieAn-Qun WangYong-Hong YangDong WangXiao-Bo DuThe aims of this study were to simultaneously evaluate the expression of Y-box binding protein-1 (YB-1) in non-neoplastic rectal tissue and rectal cancer tissue, and to collect clinical follow-up data for individual patients. Additionally, we aimed to investigate the developmental functions and prognostic value of YB-1 in rectal cancer. We performed immunohistochemical studies to examine YB-1 expression in tissue samples from 80 patients with rectal cancer, 30 patients with rectal tubular adenoma, and 30 patients with rectitis. The mean YB-1 histological scores for rectal cancer, rectal tubular adenoma, and rectitis tissue specimens were 205.5, 164.3, and 137.7, respectively. Shorter disease-free and overall survival times were found in patients with rectal cancer who had higher YB-1 expression than in those with lower expression (38.2 months vs. 52.4 months, P = 0.013; and 44.4 months vs. 57.3 months, P = 0.008, respectively). Our results indicate that YB-1 expression is higher in rectal cancer tissue than in rectal tubular adenoma and rectitis tissue and that it may be an independent prognostic factor for rectal cancer.https://doi.org/10.1371/journal.pone.0119385 |
| spellingShingle | Yu Zhang Ping-Wu Zhao Gang Feng Gang Xie An-Qun Wang Yong-Hong Yang Dong Wang Xiao-Bo Du The expression level and prognostic value of Y-box binding protein-1 in rectal cancer. PLoS ONE |
| title | The expression level and prognostic value of Y-box binding protein-1 in rectal cancer. |
| title_full | The expression level and prognostic value of Y-box binding protein-1 in rectal cancer. |
| title_fullStr | The expression level and prognostic value of Y-box binding protein-1 in rectal cancer. |
| title_full_unstemmed | The expression level and prognostic value of Y-box binding protein-1 in rectal cancer. |
| title_short | The expression level and prognostic value of Y-box binding protein-1 in rectal cancer. |
| title_sort | expression level and prognostic value of y box binding protein 1 in rectal cancer |
| url | https://doi.org/10.1371/journal.pone.0119385 |
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