EBV-Driven Lymphoproliferative Disorders and Lymphomas of the Gastrointestinal Tract: A Spectrum of Entities with a Common Denominator (Part 3)
EBV is the first known oncogenic virus involved in the development of several tumors. The majority of the global population are infected with the virus early in life and the virus persists throughout life, in a latent stage, and usually within B lymphocytes. Despite the worldwide diffusion of EBV in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/23/6021 |
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| author | Magda Zanelli Francesca Sanguedolce Andrea Palicelli Maurizio Zizzo Giovanni Martino Cecilia Caprera Valentina Fragliasso Alessandra Soriano Fabrizio Gozzi Luca Cimino Francesco Masia Marina Moretti Moira Foroni Loredana De Marco David Pellegrini Hendrik De Raeve Stefano Ricci Ione Tamagnini Alessandro Tafuni Alberto Cavazza Francesco Merli Stefano A. Pileri Stefano Ascani |
| author_facet | Magda Zanelli Francesca Sanguedolce Andrea Palicelli Maurizio Zizzo Giovanni Martino Cecilia Caprera Valentina Fragliasso Alessandra Soriano Fabrizio Gozzi Luca Cimino Francesco Masia Marina Moretti Moira Foroni Loredana De Marco David Pellegrini Hendrik De Raeve Stefano Ricci Ione Tamagnini Alessandro Tafuni Alberto Cavazza Francesco Merli Stefano A. Pileri Stefano Ascani |
| author_sort | Magda Zanelli |
| collection | DOAJ |
| description | EBV is the first known oncogenic virus involved in the development of several tumors. The majority of the global population are infected with the virus early in life and the virus persists throughout life, in a latent stage, and usually within B lymphocytes. Despite the worldwide diffusion of EBV infection, EBV-associated diseases develop in only in a small subset of individuals often when conditions of immunosuppression disrupt the balance between the infection and host immune system. EBV-driven lymphoid proliferations are either of B-cell or T/NK-cell origin, and range from disorders with an indolent behavior to aggressive lymphomas. In this review, which is divided in three parts, we provide an update of EBV-associated lymphoid disorders developing in the gastrointestinal tract, often representing a challenging diagnostic and therapeutic issue. Our aim is to provide a practical diagnostic approach to clinicians and pathologists who face this complex spectrum of disorders in their daily practice. In this part of the review, the chronic active EBV infection of T-cell and NK-cell type, its systemic form; extranodal NK/T-cell lymphoma, nasal type and post-transplant lymphoproliferative disorders are discussed. |
| first_indexed | 2024-03-10T04:55:57Z |
| format | Article |
| id | doaj.art-20ce065b3a3746ffa44270552a422105 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T04:55:57Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-20ce065b3a3746ffa44270552a4221052023-11-23T02:13:13ZengMDPI AGCancers2072-66942021-11-011323602110.3390/cancers13236021EBV-Driven Lymphoproliferative Disorders and Lymphomas of the Gastrointestinal Tract: A Spectrum of Entities with a Common Denominator (Part 3)Magda Zanelli0Francesca Sanguedolce1Andrea Palicelli2Maurizio Zizzo3Giovanni Martino4Cecilia Caprera5Valentina Fragliasso6Alessandra Soriano7Fabrizio Gozzi8Luca Cimino9Francesco Masia10Marina Moretti11Moira Foroni12Loredana De Marco13David Pellegrini14Hendrik De Raeve15Stefano Ricci16Ione Tamagnini17Alessandro Tafuni18Alberto Cavazza19Francesco Merli20Stefano A. Pileri21Stefano Ascani22Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyPathology Unit, Policlinico Riuniti, University of Foggia, 71122 Foggia, ItalyPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalySurgical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyPathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, 05100 Terni, ItalyPathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, 05100 Terni, ItalyLaboratory of Translational Research, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyGastroenterology Division, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyOcular Immunology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyOcular Immunology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyDipartimento di Medicina, Università degli Studi di Perugia, 05100 Terni, ItalyDipartimento di Medicina, Università degli Studi di Perugia, 05100 Terni, ItalyPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyPathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, 05100 Terni, ItalyPathology, University Hospital Brussels, 1090 Brussels, BelgiumPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyPathology Unit, Department of Medicine and Surgery, University of Parma, 43121 Parma, ItalyPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyHematology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyHaematopathology Division, European Institute of Oncology-IEO IRCCS Milan, 20141 Milan, ItalyPathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, 05100 Terni, ItalyEBV is the first known oncogenic virus involved in the development of several tumors. The majority of the global population are infected with the virus early in life and the virus persists throughout life, in a latent stage, and usually within B lymphocytes. Despite the worldwide diffusion of EBV infection, EBV-associated diseases develop in only in a small subset of individuals often when conditions of immunosuppression disrupt the balance between the infection and host immune system. EBV-driven lymphoid proliferations are either of B-cell or T/NK-cell origin, and range from disorders with an indolent behavior to aggressive lymphomas. In this review, which is divided in three parts, we provide an update of EBV-associated lymphoid disorders developing in the gastrointestinal tract, often representing a challenging diagnostic and therapeutic issue. Our aim is to provide a practical diagnostic approach to clinicians and pathologists who face this complex spectrum of disorders in their daily practice. In this part of the review, the chronic active EBV infection of T-cell and NK-cell type, its systemic form; extranodal NK/T-cell lymphoma, nasal type and post-transplant lymphoproliferative disorders are discussed.https://www.mdpi.com/2072-6694/13/23/6021Epstein–Barr viruschronic active EBV infectionextranodal NK/T-cell lymphomanasal typepost-transplant lymphoproliferative disorders |
| spellingShingle | Magda Zanelli Francesca Sanguedolce Andrea Palicelli Maurizio Zizzo Giovanni Martino Cecilia Caprera Valentina Fragliasso Alessandra Soriano Fabrizio Gozzi Luca Cimino Francesco Masia Marina Moretti Moira Foroni Loredana De Marco David Pellegrini Hendrik De Raeve Stefano Ricci Ione Tamagnini Alessandro Tafuni Alberto Cavazza Francesco Merli Stefano A. Pileri Stefano Ascani EBV-Driven Lymphoproliferative Disorders and Lymphomas of the Gastrointestinal Tract: A Spectrum of Entities with a Common Denominator (Part 3) Cancers Epstein–Barr virus chronic active EBV infection extranodal NK/T-cell lymphoma nasal type post-transplant lymphoproliferative disorders |
| title | EBV-Driven Lymphoproliferative Disorders and Lymphomas of the Gastrointestinal Tract: A Spectrum of Entities with a Common Denominator (Part 3) |
| title_full | EBV-Driven Lymphoproliferative Disorders and Lymphomas of the Gastrointestinal Tract: A Spectrum of Entities with a Common Denominator (Part 3) |
| title_fullStr | EBV-Driven Lymphoproliferative Disorders and Lymphomas of the Gastrointestinal Tract: A Spectrum of Entities with a Common Denominator (Part 3) |
| title_full_unstemmed | EBV-Driven Lymphoproliferative Disorders and Lymphomas of the Gastrointestinal Tract: A Spectrum of Entities with a Common Denominator (Part 3) |
| title_short | EBV-Driven Lymphoproliferative Disorders and Lymphomas of the Gastrointestinal Tract: A Spectrum of Entities with a Common Denominator (Part 3) |
| title_sort | ebv driven lymphoproliferative disorders and lymphomas of the gastrointestinal tract a spectrum of entities with a common denominator part 3 |
| topic | Epstein–Barr virus chronic active EBV infection extranodal NK/T-cell lymphoma nasal type post-transplant lymphoproliferative disorders |
| url | https://www.mdpi.com/2072-6694/13/23/6021 |
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