Synthetic Injectable Biomaterials for Alveolar Bone Regeneration in Animal and Human Studies
After tooth extraction, the alveolar ridge undergoes dimensional changes. Different bone regeneration biomaterials are used to reduce bone loss. The aim of this article was to systematically review the literature on the effect of injectable synthetic biomaterials and their advantages and disadvantag...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Series: | Materials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1996-1944/14/11/2858 |
| _version_ | 1797532507660353536 |
|---|---|
| author | Matej Tomas Marija Čandrlić Martina Juzbašić Zrinka Ivanišević Nikola Matijević Aleksandar Včev Olga Cvijanović Peloza Marko Matijević Željka Perić Kačarević |
| author_facet | Matej Tomas Marija Čandrlić Martina Juzbašić Zrinka Ivanišević Nikola Matijević Aleksandar Včev Olga Cvijanović Peloza Marko Matijević Željka Perić Kačarević |
| author_sort | Matej Tomas |
| collection | DOAJ |
| description | After tooth extraction, the alveolar ridge undergoes dimensional changes. Different bone regeneration biomaterials are used to reduce bone loss. The aim of this article was to systematically review the literature on the effect of injectable synthetic biomaterials and their advantages and disadvantages for new bone formation in the maxilla and mandible in animals and humans. A literature search was conducted in November 2020 via MEDLINE PubMed, Cochrane, and Embase. Of the 501 records screened, abstract analysis was performed on 49 articles, resulting in 21 studies that met the inclusion criteria. Animal studies have shown heterogeneity in terms of animal models, follow-up time, composition of the injectable biomaterial, and different outcome variables such as bone–implant contact, newly formed bone, and peri-implant bone density. Heterogeneity has also been demonstrated by human studies. The following outcomes were observed: newly formed bone, connective tissue, residual injectable bone graft substitute, radiographic density, residual bone height, and different follow-up periods. Further studies, especially in humans, based on the histological and biomechanical properties of the injectable delivery form, are needed to draw more concrete conclusions that will contribute to a better understanding of the benefits of this type of biomaterials and their role in bone regeneration. |
| first_indexed | 2024-03-10T11:01:12Z |
| format | Article |
| id | doaj.art-20d1106e481f4ce2b9363605db3afd42 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T11:01:12Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-20d1106e481f4ce2b9363605db3afd422023-11-21T21:30:34ZengMDPI AGMaterials1996-19442021-05-011411285810.3390/ma14112858Synthetic Injectable Biomaterials for Alveolar Bone Regeneration in Animal and Human StudiesMatej Tomas0Marija Čandrlić1Martina Juzbašić2Zrinka Ivanišević3Nikola Matijević4Aleksandar Včev5Olga Cvijanović Peloza6Marko Matijević7Željka Perić Kačarević8Department of Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, 31 000 Osijek, CroatiaDepartment of Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, 31 000 Osijek, CroatiaDepartment of Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, 31 000 Osijek, CroatiaDepartment of Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, 31 000 Osijek, CroatiaDepartment of Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, 31 000 Osijek, CroatiaDepartment of Pathophysiology, Physiology and Immunology, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, 31 000 Osijek, CroatiaDepartment of Anatomy, Medical Faculty of the University of Rijeka, 51 000 Rijeka, CroatiaDepartment of Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, 31 000 Osijek, CroatiaDepartment of Anatomy, Histology, Embriology, Pathology Anatomy and Pathology Histology, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, 31 000 Osijek, CroatiaAfter tooth extraction, the alveolar ridge undergoes dimensional changes. Different bone regeneration biomaterials are used to reduce bone loss. The aim of this article was to systematically review the literature on the effect of injectable synthetic biomaterials and their advantages and disadvantages for new bone formation in the maxilla and mandible in animals and humans. A literature search was conducted in November 2020 via MEDLINE PubMed, Cochrane, and Embase. Of the 501 records screened, abstract analysis was performed on 49 articles, resulting in 21 studies that met the inclusion criteria. Animal studies have shown heterogeneity in terms of animal models, follow-up time, composition of the injectable biomaterial, and different outcome variables such as bone–implant contact, newly formed bone, and peri-implant bone density. Heterogeneity has also been demonstrated by human studies. The following outcomes were observed: newly formed bone, connective tissue, residual injectable bone graft substitute, radiographic density, residual bone height, and different follow-up periods. Further studies, especially in humans, based on the histological and biomechanical properties of the injectable delivery form, are needed to draw more concrete conclusions that will contribute to a better understanding of the benefits of this type of biomaterials and their role in bone regeneration.https://www.mdpi.com/1996-1944/14/11/2858injectable synthetic bone graftalloplastic biomaterialsbone regeneration |
| spellingShingle | Matej Tomas Marija Čandrlić Martina Juzbašić Zrinka Ivanišević Nikola Matijević Aleksandar Včev Olga Cvijanović Peloza Marko Matijević Željka Perić Kačarević Synthetic Injectable Biomaterials for Alveolar Bone Regeneration in Animal and Human Studies Materials injectable synthetic bone graft alloplastic biomaterials bone regeneration |
| title | Synthetic Injectable Biomaterials for Alveolar Bone Regeneration in Animal and Human Studies |
| title_full | Synthetic Injectable Biomaterials for Alveolar Bone Regeneration in Animal and Human Studies |
| title_fullStr | Synthetic Injectable Biomaterials for Alveolar Bone Regeneration in Animal and Human Studies |
| title_full_unstemmed | Synthetic Injectable Biomaterials for Alveolar Bone Regeneration in Animal and Human Studies |
| title_short | Synthetic Injectable Biomaterials for Alveolar Bone Regeneration in Animal and Human Studies |
| title_sort | synthetic injectable biomaterials for alveolar bone regeneration in animal and human studies |
| topic | injectable synthetic bone graft alloplastic biomaterials bone regeneration |
| url | https://www.mdpi.com/1996-1944/14/11/2858 |
| work_keys_str_mv | AT matejtomas syntheticinjectablebiomaterialsforalveolarboneregenerationinanimalandhumanstudies AT marijacandrlic syntheticinjectablebiomaterialsforalveolarboneregenerationinanimalandhumanstudies AT martinajuzbasic syntheticinjectablebiomaterialsforalveolarboneregenerationinanimalandhumanstudies AT zrinkaivanisevic syntheticinjectablebiomaterialsforalveolarboneregenerationinanimalandhumanstudies AT nikolamatijevic syntheticinjectablebiomaterialsforalveolarboneregenerationinanimalandhumanstudies AT aleksandarvcev syntheticinjectablebiomaterialsforalveolarboneregenerationinanimalandhumanstudies AT olgacvijanovicpeloza syntheticinjectablebiomaterialsforalveolarboneregenerationinanimalandhumanstudies AT markomatijevic syntheticinjectablebiomaterialsforalveolarboneregenerationinanimalandhumanstudies AT zeljkaperickacarevic syntheticinjectablebiomaterialsforalveolarboneregenerationinanimalandhumanstudies |