Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle
Aged myoblasts suffer from impaired glycolysis and insulin resistance, but increase methionine catabolism, possibly to meet energetic demands. Here, authors show that inhibiting methionine metabolism via NANOG reprogramming or MAT2A inhibition restores the function and regeneration capacity of aged...
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Bibliographic Details
| Main Authors: |
Nika Rajabian,
Izuagie Ikhapoh,
Shahryar Shahini,
Debanik Choudhury,
Ramkumar Thiyagarajan,
Aref Shahini,
Joseph Kulczyk,
Kendall Breed,
Shilpashree Saha,
Mohamed Alaa Mohamed,
Susan B. Udin,
Aimee Stablewski,
Kenneth Seldeen,
Bruce R. Troen,
Kirkwood Personius,
Stelios T. Andreadis |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-023-36483-3
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