Epithelioid haemangioma of bone: A series of four cases with a revision of this contentious entity
Epithelioid hemangioma of bone is a rare and locally aggressive vascular neoplasm of bone associated with a good prognosis. Because of its worrisome histomorphologic features and aggressive clinicoradiologic findings, at times with multifocal presentation, they tend to simulate malignant tumors. We...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=2;spage=401;epage=405;aulast=Bansal |
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| author | Divya Bansal Sunil Pasricha Anila Sharma Manish Pruthi Akshay Tiwari Gurudutt Gupta Garima Durga Meenakshi Kamboj Vivek Mahawar Ankush Jajodia Anurag Mehta |
| author_facet | Divya Bansal Sunil Pasricha Anila Sharma Manish Pruthi Akshay Tiwari Gurudutt Gupta Garima Durga Meenakshi Kamboj Vivek Mahawar Ankush Jajodia Anurag Mehta |
| author_sort | Divya Bansal |
| collection | DOAJ |
| description | Epithelioid hemangioma of bone is a rare and locally aggressive vascular neoplasm of bone associated with a good prognosis. Because of its worrisome histomorphologic features and aggressive clinicoradiologic findings, at times with multifocal presentation, they tend to simulate malignant tumors. We report a series of four cases of epithelioid hemangioma of bone with their clinicopathologic characteristics. All had adjacent soft tissue involvement and two had multifocal bone disease. Microscopically, all cases had a tumor in lobular configuration, composed of epithelioid endothelial cells with the formation of well-formed vessels or grew in solid sheets. The tumor cells lacked significant cytologic atypia, necrosis, and increased mitosis. All cases were immunohistochemically positive for vascular markers CD34, CD31, ERG1, whereas negative for CK. Two of the cases were treated with excision, and the other two underwent curettage. None had local recurrence or metastasis on follow-up. This study highlights the importance of recognizing histomorphological and clinicoradiological features for distinguishing epithelioid hemangiomas from malignant vascular neoplasms of bone because of their distinct therapeutic implications and clinical outcomes. |
| first_indexed | 2024-12-12T02:25:40Z |
| format | Article |
| id | doaj.art-20d1abb0586e4ce397766c7f1b67700c |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-12T02:25:40Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-20d1abb0586e4ce397766c7f1b67700c2022-12-22T00:41:34ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292022-01-0165240140510.4103/IJPM.IJPM_1170_20Epithelioid haemangioma of bone: A series of four cases with a revision of this contentious entityDivya BansalSunil PasrichaAnila SharmaManish PruthiAkshay TiwariGurudutt GuptaGarima DurgaMeenakshi KambojVivek MahawarAnkush JajodiaAnurag MehtaEpithelioid hemangioma of bone is a rare and locally aggressive vascular neoplasm of bone associated with a good prognosis. Because of its worrisome histomorphologic features and aggressive clinicoradiologic findings, at times with multifocal presentation, they tend to simulate malignant tumors. We report a series of four cases of epithelioid hemangioma of bone with their clinicopathologic characteristics. All had adjacent soft tissue involvement and two had multifocal bone disease. Microscopically, all cases had a tumor in lobular configuration, composed of epithelioid endothelial cells with the formation of well-formed vessels or grew in solid sheets. The tumor cells lacked significant cytologic atypia, necrosis, and increased mitosis. All cases were immunohistochemically positive for vascular markers CD34, CD31, ERG1, whereas negative for CK. Two of the cases were treated with excision, and the other two underwent curettage. None had local recurrence or metastasis on follow-up. This study highlights the importance of recognizing histomorphological and clinicoradiological features for distinguishing epithelioid hemangiomas from malignant vascular neoplasms of bone because of their distinct therapeutic implications and clinical outcomes.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=2;spage=401;epage=405;aulast=Bansalboneepithelioidhemangiomamultifocalvascular |
| spellingShingle | Divya Bansal Sunil Pasricha Anila Sharma Manish Pruthi Akshay Tiwari Gurudutt Gupta Garima Durga Meenakshi Kamboj Vivek Mahawar Ankush Jajodia Anurag Mehta Epithelioid haemangioma of bone: A series of four cases with a revision of this contentious entity Indian Journal of Pathology and Microbiology bone epithelioid hemangioma multifocal vascular |
| title | Epithelioid haemangioma of bone: A series of four cases with a revision of this contentious entity |
| title_full | Epithelioid haemangioma of bone: A series of four cases with a revision of this contentious entity |
| title_fullStr | Epithelioid haemangioma of bone: A series of four cases with a revision of this contentious entity |
| title_full_unstemmed | Epithelioid haemangioma of bone: A series of four cases with a revision of this contentious entity |
| title_short | Epithelioid haemangioma of bone: A series of four cases with a revision of this contentious entity |
| title_sort | epithelioid haemangioma of bone a series of four cases with a revision of this contentious entity |
| topic | bone epithelioid hemangioma multifocal vascular |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=2;spage=401;epage=405;aulast=Bansal |
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