WNT Co-Receptor LRP6 Is Critical for Zygotic Genome Activation and Embryonic Developmental Potential by Interacting with Oviductal Paracrine Ligand WNT2

WNT Co-Receptor LRP6 Is Critical for Zygotic Genome Activation and Embryonic Developmental Potential by Interacting with Oviductal Paracrine Ligand WNT2

Mammalian preimplantation development depends on the interaction between embryonic autocrine and maternal paracrine signaling. Despite the robust independence of preimplantation embryos, oviductal factors are thought to be critical to pregnancy success. However, how oviductal factors regulate embryo...

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Bibliographic Details
Main Authors: Fusheng Yao, Jia Hao, Zhaochen Wang, Meiqiang Chu, Jingyu Zhang, Guangyin Xi, Zhenni Zhang, Lei An, Jianhui Tian
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Genes
Subjects:
WNT signaling
LRP6
WNT2
preimplantation embryos
zygotic genome activation
in vitro fertilization
Online Access:https://www.mdpi.com/2073-4425/14/4/891

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