Effect of intravitreal conbercept treatment before vitrectomy in proliferative diabetic retinopathy
AIM: To evaluate the safety and efficacy of intravitreal conbercept (IVC) injections as pretreatment for pars plana vitrectomy (PPV) in severe proliferative diabetic retinopathy (PDR). METHODS: This was a retrospective chart review of all patients who underwent PPV for PDR from January 2014 to Octo...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2018-07-01
|
| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.cn/en_publish/2018/7/20180723.pdf |
| _version_ | 1828185587873480704 |
|---|---|
| author | Jian-Bo Mao Han-Fei Wu Yi-Qi Chen Shi-Xin Zhao Ji-Wei Tao Yun Zhang Bin Zheng Lin Wang Li-Jun Shen |
| author_facet | Jian-Bo Mao Han-Fei Wu Yi-Qi Chen Shi-Xin Zhao Ji-Wei Tao Yun Zhang Bin Zheng Lin Wang Li-Jun Shen |
| author_sort | Jian-Bo Mao |
| collection | DOAJ |
| description | AIM: To evaluate the safety and efficacy of intravitreal conbercept (IVC) injections as pretreatment for pars plana vitrectomy (PPV) in severe proliferative diabetic retinopathy (PDR).
METHODS: This was a retrospective chart review of all patients who underwent PPV for PDR from January 2014 to October 2016. Patients who underwent IVC injection before PPV were assigned to the IVC group; the others were assigned to the control group. The IVC was performed 3-7d before surgery in the IVC group. All the eyes in the two groups were operated by the same doctor to complete the vitrectomy. Intraoperative complications and the changes in best-corrected visual acuity (BCVA) before and after surgery were compared between the two groups.
RESULTS: A total of 68 eyes of 63 patients (22 eyes in the IVC group and 46 eyes in the control group) were examined. The risk of intraoperative bleeding was lower in the IVC group (2/22) than in the control group (25/46, P=0.000). Furthermore, the use of endodiathermy was significantly lower in the IVC group (1/22) than in the control group (12/46, P=0.047). The surgical time in the IVC group (112.64±34.52min) was significantly shorter than in the control group (132.85±40.04min, P<0.05). Compared to the BCVA before surgery, the mean BCVA was significantly improved after surgery for both groups (P<0.05).
CONCLUSION: PPV is an effective treatment and can improve vision in patients with PDR. Preoperative intravitreal injection of conbercept could reduce the chances of intraoperative bleeding and the use of endodiathermy and shorten the operative time, which are beneficial in the management of PDR. |
| first_indexed | 2024-04-12T07:05:45Z |
| format | Article |
| id | doaj.art-20d4965c26ae4e01a600bcb8b62c8d44 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-12T07:05:45Z |
| publishDate | 2018-07-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-20d4965c26ae4e01a600bcb8b62c8d442022-12-22T03:42:47ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982018-07-011171217122110.18240/ijo.2018.07.23Effect of intravitreal conbercept treatment before vitrectomy in proliferative diabetic retinopathyJian-Bo Mao0Han-Fei Wu1Yi-Qi Chen2Shi-Xin Zhao3Ji-Wei Tao4Yun Zhang5Bin Zheng6Lin Wang7Li-Jun Shen8Department of Retina Center, Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou 310000, Zhejiang Province, ChinaDepartment of Retina Center, Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou 310000, Zhejiang Province, ChinaDepartment of Retina Center, Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou 310000, Zhejiang Province, ChinaDepartment of Retina Center, Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou 310000, Zhejiang Province, ChinaDepartment of Retina Center, Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou 310000, Zhejiang Province, ChinaDepartment of Retina Center, Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou 310000, Zhejiang Province, ChinaDepartment of Retina Center, Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou 310000, Zhejiang Province, ChinaAffiliated Hospital of Binzhou Medical University, Binzhou 256600, Shandong Province, ChinaDepartment of Retina Center, Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou 310000, Zhejiang Province, ChinaAIM: To evaluate the safety and efficacy of intravitreal conbercept (IVC) injections as pretreatment for pars plana vitrectomy (PPV) in severe proliferative diabetic retinopathy (PDR). METHODS: This was a retrospective chart review of all patients who underwent PPV for PDR from January 2014 to October 2016. Patients who underwent IVC injection before PPV were assigned to the IVC group; the others were assigned to the control group. The IVC was performed 3-7d before surgery in the IVC group. All the eyes in the two groups were operated by the same doctor to complete the vitrectomy. Intraoperative complications and the changes in best-corrected visual acuity (BCVA) before and after surgery were compared between the two groups. RESULTS: A total of 68 eyes of 63 patients (22 eyes in the IVC group and 46 eyes in the control group) were examined. The risk of intraoperative bleeding was lower in the IVC group (2/22) than in the control group (25/46, P=0.000). Furthermore, the use of endodiathermy was significantly lower in the IVC group (1/22) than in the control group (12/46, P=0.047). The surgical time in the IVC group (112.64±34.52min) was significantly shorter than in the control group (132.85±40.04min, P<0.05). Compared to the BCVA before surgery, the mean BCVA was significantly improved after surgery for both groups (P<0.05). CONCLUSION: PPV is an effective treatment and can improve vision in patients with PDR. Preoperative intravitreal injection of conbercept could reduce the chances of intraoperative bleeding and the use of endodiathermy and shorten the operative time, which are beneficial in the management of PDR.http://www.ijo.cn/en_publish/2018/7/20180723.pdf1221conberceptproliferative diabetic retinopathyvitrectomy |
| spellingShingle | Jian-Bo Mao Han-Fei Wu Yi-Qi Chen Shi-Xin Zhao Ji-Wei Tao Yun Zhang Bin Zheng Lin Wang Li-Jun Shen Effect of intravitreal conbercept treatment before vitrectomy in proliferative diabetic retinopathy International Journal of Ophthalmology 1221 conbercept proliferative diabetic retinopathy vitrectomy |
| title | Effect of intravitreal conbercept treatment before vitrectomy in proliferative diabetic retinopathy |
| title_full | Effect of intravitreal conbercept treatment before vitrectomy in proliferative diabetic retinopathy |
| title_fullStr | Effect of intravitreal conbercept treatment before vitrectomy in proliferative diabetic retinopathy |
| title_full_unstemmed | Effect of intravitreal conbercept treatment before vitrectomy in proliferative diabetic retinopathy |
| title_short | Effect of intravitreal conbercept treatment before vitrectomy in proliferative diabetic retinopathy |
| title_sort | effect of intravitreal conbercept treatment before vitrectomy in proliferative diabetic retinopathy |
| topic | 1221 conbercept proliferative diabetic retinopathy vitrectomy |
| url | http://www.ijo.cn/en_publish/2018/7/20180723.pdf |
| work_keys_str_mv | AT jianbomao effectofintravitrealconbercepttreatmentbeforevitrectomyinproliferativediabeticretinopathy AT hanfeiwu effectofintravitrealconbercepttreatmentbeforevitrectomyinproliferativediabeticretinopathy AT yiqichen effectofintravitrealconbercepttreatmentbeforevitrectomyinproliferativediabeticretinopathy AT shixinzhao effectofintravitrealconbercepttreatmentbeforevitrectomyinproliferativediabeticretinopathy AT jiweitao effectofintravitrealconbercepttreatmentbeforevitrectomyinproliferativediabeticretinopathy AT yunzhang effectofintravitrealconbercepttreatmentbeforevitrectomyinproliferativediabeticretinopathy AT binzheng effectofintravitrealconbercepttreatmentbeforevitrectomyinproliferativediabeticretinopathy AT linwang effectofintravitrealconbercepttreatmentbeforevitrectomyinproliferativediabeticretinopathy AT lijunshen effectofintravitrealconbercepttreatmentbeforevitrectomyinproliferativediabeticretinopathy |