Development of Ulvan-Containing Liposomes as Antibacterial Drug Delivery Platforms
Liposomes, due to their safety profile and targeting ability, are among the most studied nanocarriers as antimicrobial delivery systems. However, due to lack of stability and the non-specific interaction of liposomes with cells and proteins, their use is relatively limited. Aiming to overcome these...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/13/4/186 |
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| author | Leto-Aikaterini Tziveleka Natassa Pippa Efstathia Ioannou Costas Demetzos Vassilios Roussis |
| author_facet | Leto-Aikaterini Tziveleka Natassa Pippa Efstathia Ioannou Costas Demetzos Vassilios Roussis |
| author_sort | Leto-Aikaterini Tziveleka |
| collection | DOAJ |
| description | Liposomes, due to their safety profile and targeting ability, are among the most studied nanocarriers as antimicrobial delivery systems. However, due to lack of stability and the non-specific interaction of liposomes with cells and proteins, their use is relatively limited. Aiming to overcome these drawbacks, it was envisaged that incorporation of ulvan, a bioactive marine sulfated polysaccharide isolated from green algae, in liposomes could improve their physicochemical properties and overall stability. Thus, we initially studied the interactions of ulvan with neutral, negatively, and positively charged lipids using Differential Scanning Calorimetry and subsequently, based on the obtained results, we prepared the respective ulvan–containing neutral and charged liposomes, where ulvan interacts with both lipid chains and polar groups in the liposomal bilayer. In a further step, we entrapped in the liposomes fusidic acid, used as a model antibacterial drug, and proceeded with the evaluation of their antibacterial activity against <i>Staphylococcus aureus</i>. The physicochemical properties (size and ζ-potential), stability, morphology, and entrapment efficiency of the prepared liposomal formulations were determined. |
| first_indexed | 2024-03-09T16:15:34Z |
| format | Article |
| id | doaj.art-20d5207cef49492a8b4d22eba3aa564e |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T16:15:34Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-20d5207cef49492a8b4d22eba3aa564e2023-11-24T15:49:06ZengMDPI AGJournal of Functional Biomaterials2079-49832022-10-0113418610.3390/jfb13040186Development of Ulvan-Containing Liposomes as Antibacterial Drug Delivery PlatformsLeto-Aikaterini Tziveleka0Natassa Pippa1Efstathia Ioannou2Costas Demetzos3Vassilios Roussis4Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceSection of Pharmaceutical Technology, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceSection of Pharmaceutical Technology, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceLiposomes, due to their safety profile and targeting ability, are among the most studied nanocarriers as antimicrobial delivery systems. However, due to lack of stability and the non-specific interaction of liposomes with cells and proteins, their use is relatively limited. Aiming to overcome these drawbacks, it was envisaged that incorporation of ulvan, a bioactive marine sulfated polysaccharide isolated from green algae, in liposomes could improve their physicochemical properties and overall stability. Thus, we initially studied the interactions of ulvan with neutral, negatively, and positively charged lipids using Differential Scanning Calorimetry and subsequently, based on the obtained results, we prepared the respective ulvan–containing neutral and charged liposomes, where ulvan interacts with both lipid chains and polar groups in the liposomal bilayer. In a further step, we entrapped in the liposomes fusidic acid, used as a model antibacterial drug, and proceeded with the evaluation of their antibacterial activity against <i>Staphylococcus aureus</i>. The physicochemical properties (size and ζ-potential), stability, morphology, and entrapment efficiency of the prepared liposomal formulations were determined.https://www.mdpi.com/2079-4983/13/4/186ulvanliposomesdrug deliverynanocarrierantibacterial activity |
| spellingShingle | Leto-Aikaterini Tziveleka Natassa Pippa Efstathia Ioannou Costas Demetzos Vassilios Roussis Development of Ulvan-Containing Liposomes as Antibacterial Drug Delivery Platforms Journal of Functional Biomaterials ulvan liposomes drug delivery nanocarrier antibacterial activity |
| title | Development of Ulvan-Containing Liposomes as Antibacterial Drug Delivery Platforms |
| title_full | Development of Ulvan-Containing Liposomes as Antibacterial Drug Delivery Platforms |
| title_fullStr | Development of Ulvan-Containing Liposomes as Antibacterial Drug Delivery Platforms |
| title_full_unstemmed | Development of Ulvan-Containing Liposomes as Antibacterial Drug Delivery Platforms |
| title_short | Development of Ulvan-Containing Liposomes as Antibacterial Drug Delivery Platforms |
| title_sort | development of ulvan containing liposomes as antibacterial drug delivery platforms |
| topic | ulvan liposomes drug delivery nanocarrier antibacterial activity |
| url | https://www.mdpi.com/2079-4983/13/4/186 |
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