The effect of hydro-alcoholic extract of Licorice (Glycyrrhiza glabra) rhizome on the isolated Ileum of male rats and its interaction with Nitrergic system
Background: The licorice (Glycyrrhiza glabra) rhizome has been widely used in traditional medicine for treatment of gastrointestinal diseases. Objective: In the present study, the effect of hydro-alcoholic extract of licorice rhizome on mechanical activity of isolated ileum of male rats has been st...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Institue of Medicinal Plants, ACECR
2016-10-01
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| Series: | Journal of Medicinal Plants |
| Subjects: | |
| Online Access: | http://jmp.ir/article-1-1059-en.html |
| Summary: | Background: The licorice (Glycyrrhiza glabra) rhizome has been widely used in traditional medicine for treatment of gastrointestinal diseases.
Objective: In the present study, the effect of hydro-alcoholic extract of licorice rhizome on mechanical activity of isolated ileum of male rats has been studied.
Methods: Seven adult male rats were anesthetized by ethyl ether, their abdomen opened, and ileum dissected and divided into 1 cm segments. The segments were connected to a force transducer longitudinally and inserted to an organ bathe contained oxygenated Tyrode solution (37 °C, pH=7.4). Their mechanical activity of ileum was recorded by power lab AD instrument in basal condition, and after administration of L-NAME (10-4M) drug in the presence and absence of licorice rhizome extract (0.0175 mg/ml). Also the mechanical activity of control group segments were recorded at the same condition with extract solvent (ethanol %70).
Results: A significant decrease in mechanical activity of the isolated ileum occurred after administration of hydro-alcoholic extract of licorice compared to the control group, while the mechanical activity of ileum tissue not significantly changed in the coadministration of L-NAME and extract between experimental and control groups.
Conclusion: We can conclude that hydro-alcoholic extract of licorice has modifying effect on ileum motility, and this activity may be occurred independently to the nitrergic system. |
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| ISSN: | 2717-204X 2717-2058 |