Chemogenetic rectification of the inhibitory tone onto hippocampal neurons reverts autistic-like traits and normalizes local expression of estrogen receptors in the Ambra1+/- mouse model of female autism

Chemogenetic rectification of the inhibitory tone onto hippocampal neurons reverts autistic-like traits and normalizes local expression of estrogen receptors in the Ambra1+/- mouse model of female autism

Abstract Female, but not male, mice with haploinsufficiency for the proautophagic Ambra1 gene show an autistic-like phenotype associated with hippocampal circuits dysfunctions which include loss of parvalbuminergic interneurons (PV-IN), decrease in the inhibition/excitation ratio, and abundance of i...

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Main Authors: Annabella Pignataro, Paraskevi Krashia, Margherita De Introna, Annalisa Nobili, Annamaria Sabetta, Francesca Stabile, Livia La Barbera, Sebastian Luca D’Addario, Rossella Ventura, Francesco Cecconi, Marcello D’Amelio, Martine Ammassari-Teule
Format: Article
Language:English
Published: Nature Publishing Group 2023-02-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02357-x

Internet

https://doi.org/10.1038/s41398-023-02357-x

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