Anti-inflammatory, expectorant, and antitussive properties of Kyeongok-go in ICR mice

Context Kyeongok-go (KOG) is a traditional mixed herb preparation consisting of Panax ginseng CA Meyer (Araliaceae), Poria cocos Wolf (Polyporaceae), Rehmannia glutinosa (Gaertner) Liboschitz ex Steudel (Orobanchaceae), and honey. Various pharmacological effects of KOG are reported, but the efficacy...

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Main Authors: Jin-Ryul Hu, Chul-Jong Jung, Seong-Min Ku, Dae-Hwa Jung, Khawaja Muhammad Imran Bashir, Sae-Kwang Ku, Jae-Suk Choi
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Pharmaceutical Biology
Subjects:
Online Access:http://dx.doi.org/10.1080/13880209.2021.1892155
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author Jin-Ryul Hu
Chul-Jong Jung
Seong-Min Ku
Dae-Hwa Jung
Khawaja Muhammad Imran Bashir
Sae-Kwang Ku
Jae-Suk Choi
author_facet Jin-Ryul Hu
Chul-Jong Jung
Seong-Min Ku
Dae-Hwa Jung
Khawaja Muhammad Imran Bashir
Sae-Kwang Ku
Jae-Suk Choi
author_sort Jin-Ryul Hu
collection DOAJ
description Context Kyeongok-go (KOG) is a traditional mixed herb preparation consisting of Panax ginseng CA Meyer (Araliaceae), Poria cocos Wolf (Polyporaceae), Rehmannia glutinosa (Gaertner) Liboschitz ex Steudel (Orobanchaceae), and honey. Various pharmacological effects of KOG are reported, but the efficacy on respiratory diseases has not been evaluated. Objective The anti-inflammatory, expectorant, and antitussive properties of KOG were examined using animal models of respiratory diseases. Materials and methods KOG (100, 200, and 400 mg/kg) was orally administered to ICR mice (n = 8) once a day for 11 days. Anti-inflammatory effects of vehicle, xylene, KOG and DEXA (1 mg/kg) were determined by monitoring edoema and redness of treated ears, and measuring the relative and absolute weight of each ear. Expectorant properties of vehicle, KOG and AM (250 mg/kg) were evaluated by observing body surface redness, and the amount of mucous secreted by the trachea. The antitussive potential of vehicle, NH4OH, KOG and TB (50 mg/kg) was evaluated by monitoring changes in the number of coughs (for 6 min). Results KOG (400 mg/kg) treated mice showed 31.29% and 30.72% (p < 0.01) decreases in the relative and absolute weights of each ear relative to xylene control mice, 39.06% increases (p < 0.01) in TLF OD values relative to intact vehicle control mice, and 59.53% decrease (p < 0.01) in coughing compared to NH4OH control mice. Dose-dependent changes were observed in all experimental models. Conclusions KOG may be a potential therapeutic agent for the treatment of various respiratory diseases, particularly those caused by environmental toxins.
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spelling doaj.art-20d80552340044829d039975914c1ca22022-12-21T17:17:25ZengTaylor & Francis GroupPharmaceutical Biology1388-02091744-51162021-01-0159132133410.1080/13880209.2021.18921551892155Anti-inflammatory, expectorant, and antitussive properties of Kyeongok-go in ICR miceJin-Ryul Hu0Chul-Jong Jung1Seong-Min Ku2Dae-Hwa Jung3Khawaja Muhammad Imran Bashir4Sae-Kwang Ku5Jae-Suk Choi6Department of Histology and Anatomy, College of Korean Medicine, Daegu Haany UniversityOkchundang IncOkchundang IncDepartment of Pharmaceutical Engineering, Daegu Haany UniversityGerman Engineering Research Center for Life Science Technologies in Medicine and EnvironmentDepartment of Histology and Anatomy, College of Korean Medicine, Daegu Haany UniversityDepartment of in Food Biotechnology, College of Medical and Life Sciences, Silla UniversityContext Kyeongok-go (KOG) is a traditional mixed herb preparation consisting of Panax ginseng CA Meyer (Araliaceae), Poria cocos Wolf (Polyporaceae), Rehmannia glutinosa (Gaertner) Liboschitz ex Steudel (Orobanchaceae), and honey. Various pharmacological effects of KOG are reported, but the efficacy on respiratory diseases has not been evaluated. Objective The anti-inflammatory, expectorant, and antitussive properties of KOG were examined using animal models of respiratory diseases. Materials and methods KOG (100, 200, and 400 mg/kg) was orally administered to ICR mice (n = 8) once a day for 11 days. Anti-inflammatory effects of vehicle, xylene, KOG and DEXA (1 mg/kg) were determined by monitoring edoema and redness of treated ears, and measuring the relative and absolute weight of each ear. Expectorant properties of vehicle, KOG and AM (250 mg/kg) were evaluated by observing body surface redness, and the amount of mucous secreted by the trachea. The antitussive potential of vehicle, NH4OH, KOG and TB (50 mg/kg) was evaluated by monitoring changes in the number of coughs (for 6 min). Results KOG (400 mg/kg) treated mice showed 31.29% and 30.72% (p < 0.01) decreases in the relative and absolute weights of each ear relative to xylene control mice, 39.06% increases (p < 0.01) in TLF OD values relative to intact vehicle control mice, and 59.53% decrease (p < 0.01) in coughing compared to NH4OH control mice. Dose-dependent changes were observed in all experimental models. Conclusions KOG may be a potential therapeutic agent for the treatment of various respiratory diseases, particularly those caused by environmental toxins.http://dx.doi.org/10.1080/13880209.2021.1892155traditional mixed herbrespiratory diseaserodent experiment
spellingShingle Jin-Ryul Hu
Chul-Jong Jung
Seong-Min Ku
Dae-Hwa Jung
Khawaja Muhammad Imran Bashir
Sae-Kwang Ku
Jae-Suk Choi
Anti-inflammatory, expectorant, and antitussive properties of Kyeongok-go in ICR mice
Pharmaceutical Biology
traditional mixed herb
respiratory disease
rodent experiment
title Anti-inflammatory, expectorant, and antitussive properties of Kyeongok-go in ICR mice
title_full Anti-inflammatory, expectorant, and antitussive properties of Kyeongok-go in ICR mice
title_fullStr Anti-inflammatory, expectorant, and antitussive properties of Kyeongok-go in ICR mice
title_full_unstemmed Anti-inflammatory, expectorant, and antitussive properties of Kyeongok-go in ICR mice
title_short Anti-inflammatory, expectorant, and antitussive properties of Kyeongok-go in ICR mice
title_sort anti inflammatory expectorant and antitussive properties of kyeongok go in icr mice
topic traditional mixed herb
respiratory disease
rodent experiment
url http://dx.doi.org/10.1080/13880209.2021.1892155
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