A Mini-Review of Enteroaggregative Escherichia coli with a Specific Target on the Virulence Factors Controlled by the AggR Master Regulator
Enteroaggregative Escherichia coli (EAEC) strains have been linked to several outbreaks of severe diarrhea around the world, and this bacterium is now commonly resistant to antibiotics. As part of the pathophysiology of EAEC, the characteristic pattern of adherence looks like stacked bricks on the i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2023-12-01
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| Series: | Polish Journal of Microbiology |
| Subjects: | |
| Online Access: | https://doi.org/10.33073/pjm-2023-037 |
| _version_ | 1827387439882174464 |
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| author | Izquierdo-Vega Jeannett Alejandra Castillo-Juarez Rubi Joseline Sánchez-Gutiérrez Manuel Ares Miguel A. De La Cruz Miguel A. |
| author_facet | Izquierdo-Vega Jeannett Alejandra Castillo-Juarez Rubi Joseline Sánchez-Gutiérrez Manuel Ares Miguel A. De La Cruz Miguel A. |
| author_sort | Izquierdo-Vega Jeannett Alejandra |
| collection | DOAJ |
| description | Enteroaggregative Escherichia coli (EAEC) strains have been linked to several outbreaks of severe diarrhea around the world, and this bacterium is now commonly resistant to antibiotics. As part of the pathophysiology of EAEC, the characteristic pattern of adherence looks like stacked bricks on the intestinal epithelium. This phenotype depends on an aggregative adhesion plasmid (pAA), which codes for a regulatory protein named AggR. The AggR protein is a master regulator that transcriptionally actives the main virulence genes in this E. coli pathotype, such as those that encode the aggregative adhesion fimbriae, dispersin and its secretion apparatus, Aar regulatory protein, and type VI secretion system. Several reports have shown that AggR positively affects most EAEC virulence genes, functioning as a classic transcriptional activator in the promoter region of these genes, interacting with the RNA polymerase. This minireview article integrates the information about virulence determinants of EAEC controlled by the AggR regulator. |
| first_indexed | 2024-03-08T16:02:15Z |
| format | Article |
| id | doaj.art-20daa43cdc614269a28ea175af6eaf08 |
| institution | Directory Open Access Journal |
| issn | 2544-4646 |
| language | English |
| last_indexed | 2024-03-08T16:02:15Z |
| publishDate | 2023-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Polish Journal of Microbiology |
| spelling | doaj.art-20daa43cdc614269a28ea175af6eaf082024-01-08T09:55:32ZengSciendoPolish Journal of Microbiology2544-46462023-12-0172434735410.33073/pjm-2023-037A Mini-Review of Enteroaggregative Escherichia coli with a Specific Target on the Virulence Factors Controlled by the AggR Master RegulatorIzquierdo-Vega Jeannett Alejandra0Castillo-Juarez Rubi Joseline1Sánchez-Gutiérrez Manuel2Ares Miguel A.3De La Cruz Miguel A.41Instituto de Ciencias de la Salud, Universidad Autónoma del Estado deHidalgo, México1Instituto de Ciencias de la Salud, Universidad Autónoma del Estado deHidalgo, México1Instituto de Ciencias de la Salud, Universidad Autónoma del Estado deHidalgo, México2Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México City, México4Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, MéxicoEnteroaggregative Escherichia coli (EAEC) strains have been linked to several outbreaks of severe diarrhea around the world, and this bacterium is now commonly resistant to antibiotics. As part of the pathophysiology of EAEC, the characteristic pattern of adherence looks like stacked bricks on the intestinal epithelium. This phenotype depends on an aggregative adhesion plasmid (pAA), which codes for a regulatory protein named AggR. The AggR protein is a master regulator that transcriptionally actives the main virulence genes in this E. coli pathotype, such as those that encode the aggregative adhesion fimbriae, dispersin and its secretion apparatus, Aar regulatory protein, and type VI secretion system. Several reports have shown that AggR positively affects most EAEC virulence genes, functioning as a classic transcriptional activator in the promoter region of these genes, interacting with the RNA polymerase. This minireview article integrates the information about virulence determinants of EAEC controlled by the AggR regulator.https://doi.org/10.33073/pjm-2023-037aggregative adhesion fimbriaeaggr regulatoraggregative adhesion plasmiddispersinenteroaggregative escherichia coli |
| spellingShingle | Izquierdo-Vega Jeannett Alejandra Castillo-Juarez Rubi Joseline Sánchez-Gutiérrez Manuel Ares Miguel A. De La Cruz Miguel A. A Mini-Review of Enteroaggregative Escherichia coli with a Specific Target on the Virulence Factors Controlled by the AggR Master Regulator Polish Journal of Microbiology aggregative adhesion fimbriae aggr regulator aggregative adhesion plasmid dispersin enteroaggregative escherichia coli |
| title | A Mini-Review of Enteroaggregative Escherichia coli with a Specific Target on the Virulence Factors Controlled by the AggR Master Regulator |
| title_full | A Mini-Review of Enteroaggregative Escherichia coli with a Specific Target on the Virulence Factors Controlled by the AggR Master Regulator |
| title_fullStr | A Mini-Review of Enteroaggregative Escherichia coli with a Specific Target on the Virulence Factors Controlled by the AggR Master Regulator |
| title_full_unstemmed | A Mini-Review of Enteroaggregative Escherichia coli with a Specific Target on the Virulence Factors Controlled by the AggR Master Regulator |
| title_short | A Mini-Review of Enteroaggregative Escherichia coli with a Specific Target on the Virulence Factors Controlled by the AggR Master Regulator |
| title_sort | mini review of enteroaggregative escherichia coli with a specific target on the virulence factors controlled by the aggr master regulator |
| topic | aggregative adhesion fimbriae aggr regulator aggregative adhesion plasmid dispersin enteroaggregative escherichia coli |
| url | https://doi.org/10.33073/pjm-2023-037 |
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