Gonadotropin-secreting and thyrotropin-secreting pituitary adenomas: A single-center experience
ABSTRACT Objective: Data regarding rare FPAs from India, a resource limited setting, are limited. We describe a case series of rare FPAs from a single center in western India. Materials and methods: This was a retrospective case record review of patients diagnosed between January 2010 and July 202...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2024-02-01
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| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024000100316&lng=en&tlng=en |
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| author | Manjiri Karlekar Chakra Diwaker Vijaya Sarathi Anurag Lila Anima Sharma Saba Samad Memon Virendra Patil Tushar Bandgar |
| author_facet | Manjiri Karlekar Chakra Diwaker Vijaya Sarathi Anurag Lila Anima Sharma Saba Samad Memon Virendra Patil Tushar Bandgar |
| author_sort | Manjiri Karlekar |
| collection | DOAJ |
| description | ABSTRACT Objective: Data regarding rare FPAs from India, a resource limited setting, are limited. We describe a case series of rare FPAs from a single center in western India. Materials and methods: This was a retrospective case record review of patients diagnosed between January 2010 and July 2022. The diagnosis was based on biochemical (inappropriately elevated serum FSH/LH) and pathologic (positive immunostaining for FSH/LH) features in patients with FGA, and elevated serum thyroid hormones and normal/elevated TSH in patients with TSHomas. Results: We identified 11 patients with a total of six FGAs (median age 43.5 years, five men, one FGA cosecreting TSH, median largest dimension 40 mm, range 33–60 mm) and six TSHomas (median age 34.5 years, four women, two TSHomas cosecreting GH, median largest dimension 42.5 mm, range 13–60 mm). Symptoms of sellar mass effects led to pituitary imaging in most patients with FGA. Patients with TSHomas had symptoms of excess hormone secretion (GH/TSH) or sellar mass effects. The TSHomas that cosecreted GH/FSH were larger than those secreting only TSH. Transsphenoidal resection was the most common first-line therapy but significant residual disease was frequent (3 out of 6 FGAs and 4 out of 5 TSHomas). Conclusion: This is the first and second case series of FGAs and TSHomas, respectively, from India. In this study, TSHomas presented at younger age, were larger and had low surgical cure rates. |
| first_indexed | 2024-03-08T05:29:39Z |
| format | Article |
| id | doaj.art-20dc45488a33495aa07ce3992df096a6 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-03-08T05:29:39Z |
| publishDate | 2024-02-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-20dc45488a33495aa07ce3992df096a62024-02-06T07:42:49ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922024-02-016810.20945/2359-4292-2023-0072Gonadotropin-secreting and thyrotropin-secreting pituitary adenomas: A single-center experienceManjiri Karlekarhttps://orcid.org/0000-0001-7277-7052Chakra Diwakerhttps://orcid.org/0000-0003-2807-1890Vijaya Sarathihttps://orcid.org/0000-0002-0243-0448Anurag Lilahttps://orcid.org/0000-0002-9623-4471Anima Sharmahttps://orcid.org/0000-0002-6456-4927Saba Samad Memonhttps://orcid.org/0000-0001-5199-6299Virendra Patilhttps://orcid.org/0000-0002-2861-6267Tushar Bandgarhttps://orcid.org/0000-0002-6902-4639ABSTRACT Objective: Data regarding rare FPAs from India, a resource limited setting, are limited. We describe a case series of rare FPAs from a single center in western India. Materials and methods: This was a retrospective case record review of patients diagnosed between January 2010 and July 2022. The diagnosis was based on biochemical (inappropriately elevated serum FSH/LH) and pathologic (positive immunostaining for FSH/LH) features in patients with FGA, and elevated serum thyroid hormones and normal/elevated TSH in patients with TSHomas. Results: We identified 11 patients with a total of six FGAs (median age 43.5 years, five men, one FGA cosecreting TSH, median largest dimension 40 mm, range 33–60 mm) and six TSHomas (median age 34.5 years, four women, two TSHomas cosecreting GH, median largest dimension 42.5 mm, range 13–60 mm). Symptoms of sellar mass effects led to pituitary imaging in most patients with FGA. Patients with TSHomas had symptoms of excess hormone secretion (GH/TSH) or sellar mass effects. The TSHomas that cosecreted GH/FSH were larger than those secreting only TSH. Transsphenoidal resection was the most common first-line therapy but significant residual disease was frequent (3 out of 6 FGAs and 4 out of 5 TSHomas). Conclusion: This is the first and second case series of FGAs and TSHomas, respectively, from India. In this study, TSHomas presented at younger age, were larger and had low surgical cure rates.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024000100316&lng=en&tlng=enFunctional gonadotropinomaTSHomathyrotropinomagonadotropinoma |
| spellingShingle | Manjiri Karlekar Chakra Diwaker Vijaya Sarathi Anurag Lila Anima Sharma Saba Samad Memon Virendra Patil Tushar Bandgar Gonadotropin-secreting and thyrotropin-secreting pituitary adenomas: A single-center experience Archives of Endocrinology and Metabolism Functional gonadotropinoma TSHoma thyrotropinoma gonadotropinoma |
| title | Gonadotropin-secreting and thyrotropin-secreting pituitary adenomas: A single-center experience |
| title_full | Gonadotropin-secreting and thyrotropin-secreting pituitary adenomas: A single-center experience |
| title_fullStr | Gonadotropin-secreting and thyrotropin-secreting pituitary adenomas: A single-center experience |
| title_full_unstemmed | Gonadotropin-secreting and thyrotropin-secreting pituitary adenomas: A single-center experience |
| title_short | Gonadotropin-secreting and thyrotropin-secreting pituitary adenomas: A single-center experience |
| title_sort | gonadotropin secreting and thyrotropin secreting pituitary adenomas a single center experience |
| topic | Functional gonadotropinoma TSHoma thyrotropinoma gonadotropinoma |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024000100316&lng=en&tlng=en |
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