Effects of curcumin on the bioavailability of dioxin-like pollutants in rats
Abstract The effects of curcumin on the bioavailability of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were investigated in Sprague–Dawley rats. Tetra- and penta-chlorinated PCDFs had the lowest bioavailability and hexa-chlorinated PCDD/Fs h...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-92085-3 |
| _version_ | 1818422360582127616 |
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| author | Delei Cai Qing Chen Jianlong Han Yanhua Song Zhen Meng Yibin Zheng Haitao Shen |
| author_facet | Delei Cai Qing Chen Jianlong Han Yanhua Song Zhen Meng Yibin Zheng Haitao Shen |
| author_sort | Delei Cai |
| collection | DOAJ |
| description | Abstract The effects of curcumin on the bioavailability of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were investigated in Sprague–Dawley rats. Tetra- and penta-chlorinated PCDFs had the lowest bioavailability and hexa-chlorinated PCDD/Fs had the highest, while there was no obvious change in that of DL-PCBs. Curcumin markedly reduced the toxic equivalent (TEQ) of PCDD/Fs in rats, illustrating the potential to competitively inhibit absorption of PCDD/Fs by the epithelial cells of the small intestine due to the similar chemical structure (diphenyl) between curcumin and PCDD/Fs. Moreover, curcumin lowered the TEQ of DL-PCBs in the liver of male rats, but not female rats. The significant decrease in the bioavailability of PCDD/Fs and DL-PCBs demonstrates the potential detoxification mechanisms of curcumin. |
| first_indexed | 2024-12-14T13:25:01Z |
| format | Article |
| id | doaj.art-20dc5822835e4a9e928f4497deaea3e5 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T13:25:01Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-20dc5822835e4a9e928f4497deaea3e52022-12-21T22:59:50ZengNature PortfolioScientific Reports2045-23222021-06-011111610.1038/s41598-021-92085-3Effects of curcumin on the bioavailability of dioxin-like pollutants in ratsDelei Cai0Qing Chen1Jianlong Han2Yanhua Song3Zhen Meng4Yibin Zheng5Haitao Shen6Zhejiang Provincial Center for Disease Control and PreventionZhejiang Provincial Center for Disease Control and PreventionZhejiang Provincial Center for Disease Control and PreventionZhejiang Provincial Center for Disease Control and PreventionZhejiang Provincial Center for Disease Control and PreventionZhejiang Provincial Center for Disease Control and PreventionZhejiang Provincial Center for Disease Control and PreventionAbstract The effects of curcumin on the bioavailability of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were investigated in Sprague–Dawley rats. Tetra- and penta-chlorinated PCDFs had the lowest bioavailability and hexa-chlorinated PCDD/Fs had the highest, while there was no obvious change in that of DL-PCBs. Curcumin markedly reduced the toxic equivalent (TEQ) of PCDD/Fs in rats, illustrating the potential to competitively inhibit absorption of PCDD/Fs by the epithelial cells of the small intestine due to the similar chemical structure (diphenyl) between curcumin and PCDD/Fs. Moreover, curcumin lowered the TEQ of DL-PCBs in the liver of male rats, but not female rats. The significant decrease in the bioavailability of PCDD/Fs and DL-PCBs demonstrates the potential detoxification mechanisms of curcumin.https://doi.org/10.1038/s41598-021-92085-3 |
| spellingShingle | Delei Cai Qing Chen Jianlong Han Yanhua Song Zhen Meng Yibin Zheng Haitao Shen Effects of curcumin on the bioavailability of dioxin-like pollutants in rats Scientific Reports |
| title | Effects of curcumin on the bioavailability of dioxin-like pollutants in rats |
| title_full | Effects of curcumin on the bioavailability of dioxin-like pollutants in rats |
| title_fullStr | Effects of curcumin on the bioavailability of dioxin-like pollutants in rats |
| title_full_unstemmed | Effects of curcumin on the bioavailability of dioxin-like pollutants in rats |
| title_short | Effects of curcumin on the bioavailability of dioxin-like pollutants in rats |
| title_sort | effects of curcumin on the bioavailability of dioxin like pollutants in rats |
| url | https://doi.org/10.1038/s41598-021-92085-3 |
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