Wrecked regulation of intrinsically disordered proteins in diseases: Pathogenicity of deregulated regulators
Biologically active proteins without stable tertiary structure are common in all known proteomes. Functions of these intrinsically disordered proteins (IDPs) are typically related to regulation, signaling and control. Cellular levels of these important regulators are tightly regulated by a variety m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-07-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmolb.2014.00006/full |
| _version_ | 1811314253465911296 |
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| author | Vladimir N. Uversky |
| author_facet | Vladimir N. Uversky |
| author_sort | Vladimir N. Uversky |
| collection | DOAJ |
| description | Biologically active proteins without stable tertiary structure are common in all known proteomes. Functions of these intrinsically disordered proteins (IDPs) are typically related to regulation, signaling and control. Cellular levels of these important regulators are tightly regulated by a variety mechanisms ranging from firmly controlled expression to precisely targeted degradation. Functions of IDPs are controlled by binding to specific partners, alternative splicing, and posttranslational modifications among other means. In the norm, right amounts of precisely activated IDPs have to be present in right time at right places. Wrecked regulation brings havoc to the ordered world of disordered proteins, leading to protein misfolding, misidentification, and missignaling that give rise to numerous human diseases, such as cancer, cardiovascular disease, neurodegenerative diseases, and diabetes. Among factors inducing pathogenic transformations of IDPs are various cellular mechanisms, such as chromosomal translocations, damaged splicing, altered expression, frustrated posttranslational modifications, aberrant proteolytic degradation, and defective trafficking. This review presents some of the aspects of deregulated regulation of IDPs leading to human diseases. |
| first_indexed | 2024-04-13T11:08:31Z |
| format | Article |
| id | doaj.art-20dd6e011a324a9d82f0a15da108e720 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-13T11:08:31Z |
| publishDate | 2014-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-20dd6e011a324a9d82f0a15da108e7202022-12-22T02:49:11ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2014-07-01110.3389/fmolb.2014.00006104414Wrecked regulation of intrinsically disordered proteins in diseases: Pathogenicity of deregulated regulatorsVladimir N. Uversky0University of Soth FloridaBiologically active proteins without stable tertiary structure are common in all known proteomes. Functions of these intrinsically disordered proteins (IDPs) are typically related to regulation, signaling and control. Cellular levels of these important regulators are tightly regulated by a variety mechanisms ranging from firmly controlled expression to precisely targeted degradation. Functions of IDPs are controlled by binding to specific partners, alternative splicing, and posttranslational modifications among other means. In the norm, right amounts of precisely activated IDPs have to be present in right time at right places. Wrecked regulation brings havoc to the ordered world of disordered proteins, leading to protein misfolding, misidentification, and missignaling that give rise to numerous human diseases, such as cancer, cardiovascular disease, neurodegenerative diseases, and diabetes. Among factors inducing pathogenic transformations of IDPs are various cellular mechanisms, such as chromosomal translocations, damaged splicing, altered expression, frustrated posttranslational modifications, aberrant proteolytic degradation, and defective trafficking. This review presents some of the aspects of deregulated regulation of IDPs leading to human diseases.http://journal.frontiersin.org/Journal/10.3389/fmolb.2014.00006/fullAlternative SplicingCardiovascular DiseasesDiabetes MellitusNeurodegenerative DiseasesTranscriptional ActivationCancer |
| spellingShingle | Vladimir N. Uversky Wrecked regulation of intrinsically disordered proteins in diseases: Pathogenicity of deregulated regulators Frontiers in Molecular Biosciences Alternative Splicing Cardiovascular Diseases Diabetes Mellitus Neurodegenerative Diseases Transcriptional Activation Cancer |
| title | Wrecked regulation of intrinsically disordered proteins in diseases: Pathogenicity of deregulated regulators |
| title_full | Wrecked regulation of intrinsically disordered proteins in diseases: Pathogenicity of deregulated regulators |
| title_fullStr | Wrecked regulation of intrinsically disordered proteins in diseases: Pathogenicity of deregulated regulators |
| title_full_unstemmed | Wrecked regulation of intrinsically disordered proteins in diseases: Pathogenicity of deregulated regulators |
| title_short | Wrecked regulation of intrinsically disordered proteins in diseases: Pathogenicity of deregulated regulators |
| title_sort | wrecked regulation of intrinsically disordered proteins in diseases pathogenicity of deregulated regulators |
| topic | Alternative Splicing Cardiovascular Diseases Diabetes Mellitus Neurodegenerative Diseases Transcriptional Activation Cancer |
| url | http://journal.frontiersin.org/Journal/10.3389/fmolb.2014.00006/full |
| work_keys_str_mv | AT vladimirnuversky wreckedregulationofintrinsicallydisorderedproteinsindiseasespathogenicityofderegulatedregulators |