Loss of neuron network coherence induced by virus-infected astrocytes: a model study
Abstract Coherent activations of brain neuron networks underlie many physiological functions associated with various behavioral states. These synchronous fluctuations in the electrical activity of the brain are also referred to as brain rhythms. At the cellular level, rhythmicity can be induced by v...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-33622-0 |
| _version_ | 1827961318722764800 |
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| author | Sergey V. Stasenko Alexander E. Hramov Victor B. Kazantsev |
| author_facet | Sergey V. Stasenko Alexander E. Hramov Victor B. Kazantsev |
| author_sort | Sergey V. Stasenko |
| collection | DOAJ |
| description | Abstract Coherent activations of brain neuron networks underlie many physiological functions associated with various behavioral states. These synchronous fluctuations in the electrical activity of the brain are also referred to as brain rhythms. At the cellular level, rhythmicity can be induced by various mechanisms of intrinsic oscillations in neurons or the network circulation of excitation between synaptically coupled neurons. One specific mechanism concerns the activity of brain astrocytes that accompany neurons and can coherently modulate synaptic contacts of neighboring neurons, synchronizing their activity. Recent studies have shown that coronavirus infection (Covid-19), which enters the central nervous system and infects astrocytes, can cause various metabolic disorders. Specifically, Covid-19 can depress the synthesis of astrocytic glutamate and gamma-aminobutyric acid. It is also known that in the post-Covid state, patients may suffer from symptoms of anxiety and impaired cognitive functions. We propose a mathematical model of a spiking neuron network accompanied by astrocytes capable of generating quasi-synchronous rhythmic bursting discharges. The model predicts that if the release of glutamate is depressed, normal burst rhythmicity will suffer dramatically. Interestingly, in some cases, the failure of network coherence may be intermittent, with intervals of normal rhythmicity, or the synchronization can disappear. |
| first_indexed | 2024-04-09T16:24:52Z |
| format | Article |
| id | doaj.art-20df81de11894420acdd7aa8559f5ac5 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T16:24:52Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-20df81de11894420acdd7aa8559f5ac52023-04-23T11:14:23ZengNature PortfolioScientific Reports2045-23222023-04-0113111110.1038/s41598-023-33622-0Loss of neuron network coherence induced by virus-infected astrocytes: a model studySergey V. Stasenko0Alexander E. Hramov1Victor B. Kazantsev2Scientific—educational mathematical center “Mathematics of future technologies”, Lobachevsky UniversityBaltic Center for Artificial Intelligence and Neurotechnology, Immanuel Kant Baltic Federal UniversityScientific—educational mathematical center “Mathematics of future technologies”, Lobachevsky UniversityAbstract Coherent activations of brain neuron networks underlie many physiological functions associated with various behavioral states. These synchronous fluctuations in the electrical activity of the brain are also referred to as brain rhythms. At the cellular level, rhythmicity can be induced by various mechanisms of intrinsic oscillations in neurons or the network circulation of excitation between synaptically coupled neurons. One specific mechanism concerns the activity of brain astrocytes that accompany neurons and can coherently modulate synaptic contacts of neighboring neurons, synchronizing their activity. Recent studies have shown that coronavirus infection (Covid-19), which enters the central nervous system and infects astrocytes, can cause various metabolic disorders. Specifically, Covid-19 can depress the synthesis of astrocytic glutamate and gamma-aminobutyric acid. It is also known that in the post-Covid state, patients may suffer from symptoms of anxiety and impaired cognitive functions. We propose a mathematical model of a spiking neuron network accompanied by astrocytes capable of generating quasi-synchronous rhythmic bursting discharges. The model predicts that if the release of glutamate is depressed, normal burst rhythmicity will suffer dramatically. Interestingly, in some cases, the failure of network coherence may be intermittent, with intervals of normal rhythmicity, or the synchronization can disappear.https://doi.org/10.1038/s41598-023-33622-0 |
| spellingShingle | Sergey V. Stasenko Alexander E. Hramov Victor B. Kazantsev Loss of neuron network coherence induced by virus-infected astrocytes: a model study Scientific Reports |
| title | Loss of neuron network coherence induced by virus-infected astrocytes: a model study |
| title_full | Loss of neuron network coherence induced by virus-infected astrocytes: a model study |
| title_fullStr | Loss of neuron network coherence induced by virus-infected astrocytes: a model study |
| title_full_unstemmed | Loss of neuron network coherence induced by virus-infected astrocytes: a model study |
| title_short | Loss of neuron network coherence induced by virus-infected astrocytes: a model study |
| title_sort | loss of neuron network coherence induced by virus infected astrocytes a model study |
| url | https://doi.org/10.1038/s41598-023-33622-0 |
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