Elevated transcription and glycosylation of B3GNT5 promotes breast cancer aggressiveness

Elevated transcription and glycosylation of B3GNT5 promotes breast cancer aggressiveness

Abstract Background Basal-like breast cancer (BLBC) is the most aggressive subtype of breast cancer because of its aggressive biological characteristics and no effective targeted agents. However, the mechanism underlying its aggressive behavior remain poorly understood. β1,3-N-acetylglucosaminyltran...

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Bibliographic Details
Main Authors: Zhaorui Miao, Qianhua Cao, Ruocen Liao, Xingyu Chen, Xiaoli Li, Longchang Bai, Chenglong Ma, Xinyue Deng, Zhijun Dai, Jun Li, Chenfang Dong
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
B3GNT5
Basal-like breast cancer (BLBC)
SSEA-1
Cancer stem cells
Glycosylation
Online Access:https://doi.org/10.1186/s13046-022-02375-5

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