COVID-19: Impact of Original, Gamma, Delta, and Omicron Variants of SARS-CoV-2 in Vaccinated and Unvaccinated Pregnant and Postpartum Women
This study compares the clinical characteristics and disease progression among vaccinated and unvaccinated pregnant and postpartum women who tested positive for different variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using the Brazilian epidemiological data. Data of pregna...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/12/2172 |
| _version_ | 1797454948644945920 |
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| author | Fabiano Elisei Serra Elias Ribeiro Rosa Junior Patricia de Rossi Rossana Pulcineli Vieira Francisco Agatha Sacramento Rodrigues |
| author_facet | Fabiano Elisei Serra Elias Ribeiro Rosa Junior Patricia de Rossi Rossana Pulcineli Vieira Francisco Agatha Sacramento Rodrigues |
| author_sort | Fabiano Elisei Serra |
| collection | DOAJ |
| description | This study compares the clinical characteristics and disease progression among vaccinated and unvaccinated pregnant and postpartum women who tested positive for different variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using the Brazilian epidemiological data. Data of pregnant or postpartum patients testing positive for SARS-CoV-2 and presenting with coronavirus disease 2019 (COVID-19) from February 2020 to July 2022 were extracted from Brazilian national database. The patients were grouped based on vaccination status and viral variant (original, Gamma, Delta, and Omicron variants), and their demographics, clinical characteristics, comorbidities, symptoms, and outcomes were compared retrospectively. Data of 10,003 pregnant and 2361 postpartum women were extracted from the database. For unvaccinated postpartum women, intensive care unit (ICU) admission was more likely; invasive ventilation need was more probable if they tested positive for the original, Gamma, and Omicron variants; and chances of death were higher when infected with the original and Gamma variants than when infected with other variants. Vaccinated patients had reduced adverse outcome probability, including ICU admission, invasive ventilation requirement, and death. Postpartum women showed worse outcomes, particularly when unvaccinated, than pregnant women. Hence, vaccination of pregnant and postpartum women should be given top priority. |
| first_indexed | 2024-03-09T15:45:29Z |
| format | Article |
| id | doaj.art-20e389ed1af743dc9e0838bd8273b183 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T15:45:29Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-20e389ed1af743dc9e0838bd8273b1832023-11-24T18:34:03ZengMDPI AGVaccines2076-393X2022-12-011012217210.3390/vaccines10122172COVID-19: Impact of Original, Gamma, Delta, and Omicron Variants of SARS-CoV-2 in Vaccinated and Unvaccinated Pregnant and Postpartum WomenFabiano Elisei Serra0Elias Ribeiro Rosa Junior1Patricia de Rossi2Rossana Pulcineli Vieira Francisco3Agatha Sacramento Rodrigues4Disciplina de Obstetrícia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo 05508-070, BrazilDepartamento de Estatística, Universidade Federal do Espírito Santo, 514 Fernando Ferrari Avenue, Vitória 29075-910, BrazilFaculdade de Medicina, Universidade de Santo Amaro (UNISA), São Paulo 04743-030, BrazilDisciplina de Obstetrícia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo 05508-070, BrazilDisciplina de Obstetrícia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo 05508-070, BrazilThis study compares the clinical characteristics and disease progression among vaccinated and unvaccinated pregnant and postpartum women who tested positive for different variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using the Brazilian epidemiological data. Data of pregnant or postpartum patients testing positive for SARS-CoV-2 and presenting with coronavirus disease 2019 (COVID-19) from February 2020 to July 2022 were extracted from Brazilian national database. The patients were grouped based on vaccination status and viral variant (original, Gamma, Delta, and Omicron variants), and their demographics, clinical characteristics, comorbidities, symptoms, and outcomes were compared retrospectively. Data of 10,003 pregnant and 2361 postpartum women were extracted from the database. For unvaccinated postpartum women, intensive care unit (ICU) admission was more likely; invasive ventilation need was more probable if they tested positive for the original, Gamma, and Omicron variants; and chances of death were higher when infected with the original and Gamma variants than when infected with other variants. Vaccinated patients had reduced adverse outcome probability, including ICU admission, invasive ventilation requirement, and death. Postpartum women showed worse outcomes, particularly when unvaccinated, than pregnant women. Hence, vaccination of pregnant and postpartum women should be given top priority.https://www.mdpi.com/2076-393X/10/12/2172COVID-19SARS-CoV-2vaccinespregnancypostpartum periodpuerperal period |
| spellingShingle | Fabiano Elisei Serra Elias Ribeiro Rosa Junior Patricia de Rossi Rossana Pulcineli Vieira Francisco Agatha Sacramento Rodrigues COVID-19: Impact of Original, Gamma, Delta, and Omicron Variants of SARS-CoV-2 in Vaccinated and Unvaccinated Pregnant and Postpartum Women Vaccines COVID-19 SARS-CoV-2 vaccines pregnancy postpartum period puerperal period |
| title | COVID-19: Impact of Original, Gamma, Delta, and Omicron Variants of SARS-CoV-2 in Vaccinated and Unvaccinated Pregnant and Postpartum Women |
| title_full | COVID-19: Impact of Original, Gamma, Delta, and Omicron Variants of SARS-CoV-2 in Vaccinated and Unvaccinated Pregnant and Postpartum Women |
| title_fullStr | COVID-19: Impact of Original, Gamma, Delta, and Omicron Variants of SARS-CoV-2 in Vaccinated and Unvaccinated Pregnant and Postpartum Women |
| title_full_unstemmed | COVID-19: Impact of Original, Gamma, Delta, and Omicron Variants of SARS-CoV-2 in Vaccinated and Unvaccinated Pregnant and Postpartum Women |
| title_short | COVID-19: Impact of Original, Gamma, Delta, and Omicron Variants of SARS-CoV-2 in Vaccinated and Unvaccinated Pregnant and Postpartum Women |
| title_sort | covid 19 impact of original gamma delta and omicron variants of sars cov 2 in vaccinated and unvaccinated pregnant and postpartum women |
| topic | COVID-19 SARS-CoV-2 vaccines pregnancy postpartum period puerperal period |
| url | https://www.mdpi.com/2076-393X/10/12/2172 |
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