Immune Evasion by the Highly Mutated SARS-CoV-2 Omicron Variant
Hylemariam Mihiretie Mengist,1 John Arnaud Kombe Kombe,2 Tengchuan Jin2,3 1Department of Obstetrics and Gynecology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of China; 2Hefei N...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-07-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/immune-evasion-by-the-highly-mutated-sars-cov-2-omicron-variant-peer-reviewed-fulltext-article-IDR |
| _version_ | 1811312465784340480 |
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| author | Mengist HM Kombe Kombe JA Jin T |
| author_facet | Mengist HM Kombe Kombe JA Jin T |
| author_sort | Mengist HM |
| collection | DOAJ |
| description | Hylemariam Mihiretie Mengist,1 John Arnaud Kombe Kombe,2 Tengchuan Jin2,3 1Department of Obstetrics and Gynecology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of China; 2Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, People’s Republic of China; 3CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Science, Shanghai, 200031, People’s Republic of ChinaCorrespondence: Tengchuan Jin, Email jint@ustc.edu.cnAbstract: The currently circulating SARS-CoV-2 Omicron variant posed a big challenge for the ongoing pandemic prevention and control activities. The critical concern is whether the current vaccines and therapeutics are capable of fully controlling this variant. Omicron has several mutations mainly concentrated in the receptor-binding domain (RBD) which is the main target for neutralizing antibodies and vaccine-elicited sera, and it is reportedly evading immunity. However, the degree to which the Omicron evades immunity and its impact on the prevention and control activities requires recent and continuous scrutiny. Despite several reports are available, updated and recent discussions are important to tackle the ongoing pandemic especially due to the emerging SARS-CoV-2 variants. Therefore, new insights on designing effective preventive and control measures is utmost important. This review discusses the extent of immune evasion by the Omicron variant and forwards important directions which could have valuable contributions to design alternative strategies in fighting against SARS-Co-2 variants.Keywords: SARSC-CoV-2, variant of concern, VOC, Omicron variant, immune evasion, receptor-binding domain, RBD |
| first_indexed | 2024-04-13T10:37:52Z |
| format | Article |
| id | doaj.art-20e3c1d406324df1b0de74e3f6cc052e |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-13T10:37:52Z |
| publishDate | 2022-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-20e3c1d406324df1b0de74e3f6cc052e2022-12-22T02:50:00ZengDove Medical PressInfection and Drug Resistance1178-69732022-07-01Volume 154013402776817Immune Evasion by the Highly Mutated SARS-CoV-2 Omicron VariantMengist HMKombe Kombe JAJin THylemariam Mihiretie Mengist,1 John Arnaud Kombe Kombe,2 Tengchuan Jin2,3 1Department of Obstetrics and Gynecology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of China; 2Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, People’s Republic of China; 3CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Science, Shanghai, 200031, People’s Republic of ChinaCorrespondence: Tengchuan Jin, Email jint@ustc.edu.cnAbstract: The currently circulating SARS-CoV-2 Omicron variant posed a big challenge for the ongoing pandemic prevention and control activities. The critical concern is whether the current vaccines and therapeutics are capable of fully controlling this variant. Omicron has several mutations mainly concentrated in the receptor-binding domain (RBD) which is the main target for neutralizing antibodies and vaccine-elicited sera, and it is reportedly evading immunity. However, the degree to which the Omicron evades immunity and its impact on the prevention and control activities requires recent and continuous scrutiny. Despite several reports are available, updated and recent discussions are important to tackle the ongoing pandemic especially due to the emerging SARS-CoV-2 variants. Therefore, new insights on designing effective preventive and control measures is utmost important. This review discusses the extent of immune evasion by the Omicron variant and forwards important directions which could have valuable contributions to design alternative strategies in fighting against SARS-Co-2 variants.Keywords: SARSC-CoV-2, variant of concern, VOC, Omicron variant, immune evasion, receptor-binding domain, RBDhttps://www.dovepress.com/immune-evasion-by-the-highly-mutated-sars-cov-2-omicron-variant-peer-reviewed-fulltext-article-IDRsarsc-cov-2variant of concern (voc)omicron variantimmune evasionreceptor-binding domain (rbd) |
| spellingShingle | Mengist HM Kombe Kombe JA Jin T Immune Evasion by the Highly Mutated SARS-CoV-2 Omicron Variant Infection and Drug Resistance sarsc-cov-2 variant of concern (voc) omicron variant immune evasion receptor-binding domain (rbd) |
| title | Immune Evasion by the Highly Mutated SARS-CoV-2 Omicron Variant |
| title_full | Immune Evasion by the Highly Mutated SARS-CoV-2 Omicron Variant |
| title_fullStr | Immune Evasion by the Highly Mutated SARS-CoV-2 Omicron Variant |
| title_full_unstemmed | Immune Evasion by the Highly Mutated SARS-CoV-2 Omicron Variant |
| title_short | Immune Evasion by the Highly Mutated SARS-CoV-2 Omicron Variant |
| title_sort | immune evasion by the highly mutated sars cov 2 omicron variant |
| topic | sarsc-cov-2 variant of concern (voc) omicron variant immune evasion receptor-binding domain (rbd) |
| url | https://www.dovepress.com/immune-evasion-by-the-highly-mutated-sars-cov-2-omicron-variant-peer-reviewed-fulltext-article-IDR |
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