Producing Vaccines against Enveloped Viruses in Plants: Making the Impossible, Difficult
The past 30 years have seen the growth of plant molecular farming as an approach to the production of recombinant proteins for pharmaceutical and biotechnological uses. Much of this effort has focused on producing vaccine candidates against viral diseases, including those caused by enveloped viruses...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/7/780 |
| _version_ | 1827686772822245376 |
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| author | Hadrien Peyret John F. C. Steele Jae-Wan Jung Eva C. Thuenemann Yulia Meshcheriakova George P. Lomonossoff |
| author_facet | Hadrien Peyret John F. C. Steele Jae-Wan Jung Eva C. Thuenemann Yulia Meshcheriakova George P. Lomonossoff |
| author_sort | Hadrien Peyret |
| collection | DOAJ |
| description | The past 30 years have seen the growth of plant molecular farming as an approach to the production of recombinant proteins for pharmaceutical and biotechnological uses. Much of this effort has focused on producing vaccine candidates against viral diseases, including those caused by enveloped viruses. These represent a particular challenge given the difficulties associated with expressing and purifying membrane-bound proteins and achieving correct assembly. Despite this, there have been notable successes both from a biochemical and a clinical perspective, with a number of clinical trials showing great promise. This review will explore the history and current status of plant-produced vaccine candidates against enveloped viruses to date, with a particular focus on virus-like particles (VLPs), which mimic authentic virus structures but do not contain infectious genetic material. |
| first_indexed | 2024-03-10T09:20:31Z |
| format | Article |
| id | doaj.art-20e45d578d1945a18793daa31dc91e0c |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T09:20:31Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-20e45d578d1945a18793daa31dc91e0c2023-11-22T05:12:56ZengMDPI AGVaccines2076-393X2021-07-019778010.3390/vaccines9070780Producing Vaccines against Enveloped Viruses in Plants: Making the Impossible, DifficultHadrien Peyret0John F. C. Steele1Jae-Wan Jung2Eva C. Thuenemann3Yulia Meshcheriakova4George P. Lomonossoff5Department of Biochemistry and Metabolism, John Innes Centre, Norwich NR4 7UH, UKDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich NR4 7UH, UKDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich NR4 7UH, UKDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich NR4 7UH, UKDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich NR4 7UH, UKDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich NR4 7UH, UKThe past 30 years have seen the growth of plant molecular farming as an approach to the production of recombinant proteins for pharmaceutical and biotechnological uses. Much of this effort has focused on producing vaccine candidates against viral diseases, including those caused by enveloped viruses. These represent a particular challenge given the difficulties associated with expressing and purifying membrane-bound proteins and achieving correct assembly. Despite this, there have been notable successes both from a biochemical and a clinical perspective, with a number of clinical trials showing great promise. This review will explore the history and current status of plant-produced vaccine candidates against enveloped viruses to date, with a particular focus on virus-like particles (VLPs), which mimic authentic virus structures but do not contain infectious genetic material.https://www.mdpi.com/2076-393X/9/7/780alphavirus<i>Bunyavirales</i>coronavirus<i>Flaviviridae</i>hepatitis B virushuman immunodeficiency virus |
| spellingShingle | Hadrien Peyret John F. C. Steele Jae-Wan Jung Eva C. Thuenemann Yulia Meshcheriakova George P. Lomonossoff Producing Vaccines against Enveloped Viruses in Plants: Making the Impossible, Difficult Vaccines alphavirus <i>Bunyavirales</i> coronavirus <i>Flaviviridae</i> hepatitis B virus human immunodeficiency virus |
| title | Producing Vaccines against Enveloped Viruses in Plants: Making the Impossible, Difficult |
| title_full | Producing Vaccines against Enveloped Viruses in Plants: Making the Impossible, Difficult |
| title_fullStr | Producing Vaccines against Enveloped Viruses in Plants: Making the Impossible, Difficult |
| title_full_unstemmed | Producing Vaccines against Enveloped Viruses in Plants: Making the Impossible, Difficult |
| title_short | Producing Vaccines against Enveloped Viruses in Plants: Making the Impossible, Difficult |
| title_sort | producing vaccines against enveloped viruses in plants making the impossible difficult |
| topic | alphavirus <i>Bunyavirales</i> coronavirus <i>Flaviviridae</i> hepatitis B virus human immunodeficiency virus |
| url | https://www.mdpi.com/2076-393X/9/7/780 |
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