NETosis as an oncologic therapeutic target: a mini review
Neutrophil Extracellular Traps (NETs) are a key form of pro-inflammatory cell death of neutrophils characterized by the extrusion of extracellular webs of DNA containing bactericidal killing enzymes. NETosis is heavily implicated as a key driver of host damage in autoimmune diseases where injurious...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1170603/full |
| _version_ | 1827965316756406272 |
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| author | Sarah Jaboury Kenny Wang Kim Maree O’Sullivan Joshua Daniel Ooi Gwo Yaw Ho Gwo Yaw Ho |
| author_facet | Sarah Jaboury Kenny Wang Kim Maree O’Sullivan Joshua Daniel Ooi Gwo Yaw Ho Gwo Yaw Ho |
| author_sort | Sarah Jaboury |
| collection | DOAJ |
| description | Neutrophil Extracellular Traps (NETs) are a key form of pro-inflammatory cell death of neutrophils characterized by the extrusion of extracellular webs of DNA containing bactericidal killing enzymes. NETosis is heavily implicated as a key driver of host damage in autoimmune diseases where injurious release of proinflammatory enzymes damage surrounding tissue and releases 70 known autoantigens. Recent evidence shows that both neutrophils and NETosis have a role to play in carcinogenesis, both indirectly through triggering DNA damage through inflammation, and directly contributing to a pro-tumorigenic tumor microenvironment. In this mini-review, we summarize the current knowledge of the various mechanisms of interaction and influence between neutrophils, with particular attention to NETosis, and cancer cells. We will also highlight the potential avenues thus far explored where we can intercept these processes, with the aim of identifying promising prospective targets in cancer treatment to be explored in further studies. |
| first_indexed | 2024-04-09T17:31:07Z |
| format | Article |
| id | doaj.art-20e47fac67ae414a929e391132579c14 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T17:31:07Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-20e47fac67ae414a929e391132579c142023-04-18T04:19:05ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-04-011410.3389/fimmu.2023.11706031170603NETosis as an oncologic therapeutic target: a mini reviewSarah Jaboury0Kenny Wang1Kim Maree O’Sullivan2Joshua Daniel Ooi3Gwo Yaw Ho4Gwo Yaw Ho5Department of Oncology, Monash Health, Clayton, VIC, AustraliaSchool of Clinical Sciences, Monash University, Melbourne, VIC, AustraliaSchool of Clinical Sciences, Monash University, Melbourne, VIC, AustraliaSchool of Clinical Sciences, Monash University, Melbourne, VIC, AustraliaDepartment of Oncology, Monash Health, Clayton, VIC, AustraliaSchool of Clinical Sciences, Monash University, Melbourne, VIC, AustraliaNeutrophil Extracellular Traps (NETs) are a key form of pro-inflammatory cell death of neutrophils characterized by the extrusion of extracellular webs of DNA containing bactericidal killing enzymes. NETosis is heavily implicated as a key driver of host damage in autoimmune diseases where injurious release of proinflammatory enzymes damage surrounding tissue and releases 70 known autoantigens. Recent evidence shows that both neutrophils and NETosis have a role to play in carcinogenesis, both indirectly through triggering DNA damage through inflammation, and directly contributing to a pro-tumorigenic tumor microenvironment. In this mini-review, we summarize the current knowledge of the various mechanisms of interaction and influence between neutrophils, with particular attention to NETosis, and cancer cells. We will also highlight the potential avenues thus far explored where we can intercept these processes, with the aim of identifying promising prospective targets in cancer treatment to be explored in further studies.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1170603/fullneutrophilNETosiscancerinnate immunitytumor microenvironment |
| spellingShingle | Sarah Jaboury Kenny Wang Kim Maree O’Sullivan Joshua Daniel Ooi Gwo Yaw Ho Gwo Yaw Ho NETosis as an oncologic therapeutic target: a mini review Frontiers in Immunology neutrophil NETosis cancer innate immunity tumor microenvironment |
| title | NETosis as an oncologic therapeutic target: a mini review |
| title_full | NETosis as an oncologic therapeutic target: a mini review |
| title_fullStr | NETosis as an oncologic therapeutic target: a mini review |
| title_full_unstemmed | NETosis as an oncologic therapeutic target: a mini review |
| title_short | NETosis as an oncologic therapeutic target: a mini review |
| title_sort | netosis as an oncologic therapeutic target a mini review |
| topic | neutrophil NETosis cancer innate immunity tumor microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1170603/full |
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