Diagnostic and prognostic laboratory criteria for the development of sepsis in purulent-inflammatory diseases of soft tissues
Objective. Identification of laboratory parameters that are used in routine practice and can serve as diagnostic and prognostic criteria for the development of sepsis and its outcomes in patients with purulent-inflammatory diseases of soft tissues.Materials and methods. The study included 48 patient...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Journal Infectology
2019-05-01
|
| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/884 |
| _version_ | 1826557816622546944 |
|---|---|
| author | G. S. Golobokov V. V. Tsvetkov I. I. Tokin S. D. Shejanov A. B. Levashova D. A. Lioznov |
| author_facet | G. S. Golobokov V. V. Tsvetkov I. I. Tokin S. D. Shejanov A. B. Levashova D. A. Lioznov |
| author_sort | G. S. Golobokov |
| collection | DOAJ |
| description | Objective. Identification of laboratory parameters that are used in routine practice and can serve as diagnostic and prognostic criteria for the development of sepsis and its outcomes in patients with purulent-inflammatory diseases of soft tissues.Materials and methods. The study included 48 patients with purulent-inflammatory diseases of soft tissues. Recorded the occurrence of such clinical events as the development of sepsis or septic shock, intensive therapy, death or recovery and discharge from the hospital. For the diagnosis of sepsis, a SOFA (Sepsis-related organ failure assessment score) ³ 2 points was used. Patients were divided into subgroups according to the number of points according to the SOFA scale, intensive care and depending on the outcome of the disease: Subgroup 1 – 26 patients with sepsis (SOFA ³ 2 points) and 22 patients with systemic inflammatory response syndrome (SIRS) and SOFA <2 points; 2nd subgroup – 12 people who underwent intensive therapy and 36 people without it; 3rd subgroup – 7 patients with a fatal outcome and 41 patients with a favorable outcome.Results. In patients with sepsis, albumin concentration was 24,07 g / l in median versus 34,65 g / l in the control group of patients with SOFA <2 points (p <0,01); glucose -7,82 mmol / l and 5,15 mmol / l (p <0,01); sodium concentration of 133 mmol / li 139 mmol / l (p <0,01). The values of the international normalized ratio (INR) amounted to a median of 1,29 and 1,04 (p <0,01); activated partial thromboplastin time -36,20 seconds and 31,50 seconds (p <0,01). In the subgroup of patients for whom intensive therapy was required, the concentration of albumin was 22,34 g / l by median versus 30,10 g / l (p <0,01); urea – 15,50 mmol / l versus 6,00 mmol / l (p <0,05), glucose – 9,61 mmol / l against 5,80 mmol / l (p <0,05), lactate dehydrogenase-644,00 U / l and 426,00 U / l (p <0,05); INR – 1,35 against 1,05 (p <0,05). The aver-age total protein concentration is 47,80 g / l versus 57,90 g / l (p <0,01). The average albumin is 22,34 g / l versus 28,50 g / l (p <0,05). The glucose concentration among patients with a fatal outcome was 12,00 mmol / l in median versus 5,95 mmol / l (p <0,01); urea – 23,22 mmol / l versus 6,00 mmol / l (p <0,01). The incidence of lethal disease was statistically significantly higher in patients with a total protein level of less than 52 g / l 5,96 times (RR = 5,96, 95% CI 1,32 – 26,89), glucose more than 11 mmol / l – 7,00 times (OR = 7,00, 95% CI 1,25 – 39,15), urea more than 20 mmol / l – 7,05 times (RR = 7,05, 95% CI 2,00 – 24,85).Conclusion. Routine laboratory indicators as the level of total protein, albumin, glucose, sodium and urea, as well as indicators of the blood coagulation system (INR and APTT), can serve as diagnostic and prognostic criteria for the development of sepsis and its outcomes in patients with purulentinflammatory diseases. soft tissue. |
| first_indexed | 2024-03-12T04:45:40Z |
| format | Article |
| id | doaj.art-20e498484dbc4a5499e3fab33ac43d09 |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2025-03-14T08:34:37Z |
| publishDate | 2019-05-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-20e498484dbc4a5499e3fab33ac43d092025-03-02T13:00:31ZrusJournal InfectologyЖурнал инфектологии2072-67322019-05-01112536210.22625/2072-6732-2019-11-2-53-62722Diagnostic and prognostic laboratory criteria for the development of sepsis in purulent-inflammatory diseases of soft tissuesG. S. Golobokov0V. V. Tsvetkov1I. I. Tokin2S. D. Shejanov3A. B. Levashova4D. A. Lioznov5Research Institute of Influenza named after A.A. SmorodintsevResearch Institute of Influenza named after A.A. SmorodintsevResearch Institute of Influenza named after A.A. Smorodintsev; North-Western State Medical University named after I.I. MechnikovCity Hospital № 14City Hospital № 14Research Institute of Influenza named after A.A. Smorodintsev; First Saint-Petersburg State Medical University named after academician I.P. PavlovObjective. Identification of laboratory parameters that are used in routine practice and can serve as diagnostic and prognostic criteria for the development of sepsis and its outcomes in patients with purulent-inflammatory diseases of soft tissues.Materials and methods. The study included 48 patients with purulent-inflammatory diseases of soft tissues. Recorded the occurrence of such clinical events as the development of sepsis or septic shock, intensive therapy, death or recovery and discharge from the hospital. For the diagnosis of sepsis, a SOFA (Sepsis-related organ failure assessment score) ³ 2 points was used. Patients were divided into subgroups according to the number of points according to the SOFA scale, intensive care and depending on the outcome of the disease: Subgroup 1 – 26 patients with sepsis (SOFA ³ 2 points) and 22 patients with systemic inflammatory response syndrome (SIRS) and SOFA <2 points; 2nd subgroup – 12 people who underwent intensive therapy and 36 people without it; 3rd subgroup – 7 patients with a fatal outcome and 41 patients with a favorable outcome.Results. In patients with sepsis, albumin concentration was 24,07 g / l in median versus 34,65 g / l in the control group of patients with SOFA <2 points (p <0,01); glucose -7,82 mmol / l and 5,15 mmol / l (p <0,01); sodium concentration of 133 mmol / li 139 mmol / l (p <0,01). The values of the international normalized ratio (INR) amounted to a median of 1,29 and 1,04 (p <0,01); activated partial thromboplastin time -36,20 seconds and 31,50 seconds (p <0,01). In the subgroup of patients for whom intensive therapy was required, the concentration of albumin was 22,34 g / l by median versus 30,10 g / l (p <0,01); urea – 15,50 mmol / l versus 6,00 mmol / l (p <0,05), glucose – 9,61 mmol / l against 5,80 mmol / l (p <0,05), lactate dehydrogenase-644,00 U / l and 426,00 U / l (p <0,05); INR – 1,35 against 1,05 (p <0,05). The aver-age total protein concentration is 47,80 g / l versus 57,90 g / l (p <0,01). The average albumin is 22,34 g / l versus 28,50 g / l (p <0,05). The glucose concentration among patients with a fatal outcome was 12,00 mmol / l in median versus 5,95 mmol / l (p <0,01); urea – 23,22 mmol / l versus 6,00 mmol / l (p <0,01). The incidence of lethal disease was statistically significantly higher in patients with a total protein level of less than 52 g / l 5,96 times (RR = 5,96, 95% CI 1,32 – 26,89), glucose more than 11 mmol / l – 7,00 times (OR = 7,00, 95% CI 1,25 – 39,15), urea more than 20 mmol / l – 7,05 times (RR = 7,05, 95% CI 2,00 – 24,85).Conclusion. Routine laboratory indicators as the level of total protein, albumin, glucose, sodium and urea, as well as indicators of the blood coagulation system (INR and APTT), can serve as diagnostic and prognostic criteria for the development of sepsis and its outcomes in patients with purulentinflammatory diseases. soft tissue.https://journal.niidi.ru/jofin/article/view/884inflammatory soft tissue diseasessepsisdiagnosispredictors |
| spellingShingle | G. S. Golobokov V. V. Tsvetkov I. I. Tokin S. D. Shejanov A. B. Levashova D. A. Lioznov Diagnostic and prognostic laboratory criteria for the development of sepsis in purulent-inflammatory diseases of soft tissues Журнал инфектологии inflammatory soft tissue diseases sepsis diagnosis predictors |
| title | Diagnostic and prognostic laboratory criteria for the development of sepsis in purulent-inflammatory diseases of soft tissues |
| title_full | Diagnostic and prognostic laboratory criteria for the development of sepsis in purulent-inflammatory diseases of soft tissues |
| title_fullStr | Diagnostic and prognostic laboratory criteria for the development of sepsis in purulent-inflammatory diseases of soft tissues |
| title_full_unstemmed | Diagnostic and prognostic laboratory criteria for the development of sepsis in purulent-inflammatory diseases of soft tissues |
| title_short | Diagnostic and prognostic laboratory criteria for the development of sepsis in purulent-inflammatory diseases of soft tissues |
| title_sort | diagnostic and prognostic laboratory criteria for the development of sepsis in purulent inflammatory diseases of soft tissues |
| topic | inflammatory soft tissue diseases sepsis diagnosis predictors |
| url | https://journal.niidi.ru/jofin/article/view/884 |
| work_keys_str_mv | AT gsgolobokov diagnosticandprognosticlaboratorycriteriaforthedevelopmentofsepsisinpurulentinflammatorydiseasesofsofttissues AT vvtsvetkov diagnosticandprognosticlaboratorycriteriaforthedevelopmentofsepsisinpurulentinflammatorydiseasesofsofttissues AT iitokin diagnosticandprognosticlaboratorycriteriaforthedevelopmentofsepsisinpurulentinflammatorydiseasesofsofttissues AT sdshejanov diagnosticandprognosticlaboratorycriteriaforthedevelopmentofsepsisinpurulentinflammatorydiseasesofsofttissues AT ablevashova diagnosticandprognosticlaboratorycriteriaforthedevelopmentofsepsisinpurulentinflammatorydiseasesofsofttissues AT dalioznov diagnosticandprognosticlaboratorycriteriaforthedevelopmentofsepsisinpurulentinflammatorydiseasesofsofttissues |