Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production
A novel gedunin and two novel phragmalin-type limonoids, named carapanolides J–L (compounds 1–3) as well as a known gedunin-type limonoid 4 were isolated from the seeds of Carapa guianensis (andiroba). Their structures were determined on the basis of 1D and 2D NMR spectroscopy and HRFABMS. Compounds...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-10-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/11/17130 |
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| author | Yuuki Matsui Takashi Kikuchi Takanobu Inoue Osamu Muraoka Takeshi Yamada Reiko Tanaka |
| author_facet | Yuuki Matsui Takashi Kikuchi Takanobu Inoue Osamu Muraoka Takeshi Yamada Reiko Tanaka |
| author_sort | Yuuki Matsui |
| collection | DOAJ |
| description | A novel gedunin and two novel phragmalin-type limonoids, named carapanolides J–L (compounds 1–3) as well as a known gedunin-type limonoid 4 were isolated from the seeds of Carapa guianensis (andiroba). Their structures were determined on the basis of 1D and 2D NMR spectroscopy and HRFABMS. Compounds 1–4 were evaluated for their effects on the production of NO in LPS-activated mouse peritoneal macrophages. |
| first_indexed | 2024-04-13T12:15:47Z |
| format | Article |
| id | doaj.art-20e5c9b850a0404baf95ea0e05abef9d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T12:15:47Z |
| publishDate | 2014-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-20e5c9b850a0404baf95ea0e05abef9d2022-12-22T02:47:21ZengMDPI AGMolecules1420-30492014-10-011911171301714010.3390/molecules191117130molecules191117130Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO ProductionYuuki Matsui0Takashi Kikuchi1Takanobu Inoue2Osamu Muraoka3Takeshi Yamada4Reiko Tanaka5Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, JapanLaboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, JapanLaboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, JapanFaculty of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, Higashiosaka, Osaka 577-8502, JapanLaboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, JapanLaboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, JapanA novel gedunin and two novel phragmalin-type limonoids, named carapanolides J–L (compounds 1–3) as well as a known gedunin-type limonoid 4 were isolated from the seeds of Carapa guianensis (andiroba). Their structures were determined on the basis of 1D and 2D NMR spectroscopy and HRFABMS. Compounds 1–4 were evaluated for their effects on the production of NO in LPS-activated mouse peritoneal macrophages.http://www.mdpi.com/1420-3049/19/11/17130Carapa guianensisandirobaseedsgeduninphragmalinlimonoidsNO production |
| spellingShingle | Yuuki Matsui Takashi Kikuchi Takanobu Inoue Osamu Muraoka Takeshi Yamada Reiko Tanaka Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production Molecules Carapa guianensis andiroba seeds gedunin phragmalin limonoids NO production |
| title | Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production |
| title_full | Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production |
| title_fullStr | Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production |
| title_full_unstemmed | Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production |
| title_short | Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production |
| title_sort | carapanolides j l from the seeds of carapa guianensis andiroba and their effects on lps activated no production |
| topic | Carapa guianensis andiroba seeds gedunin phragmalin limonoids NO production |
| url | http://www.mdpi.com/1420-3049/19/11/17130 |
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