Metabolic Syndrome and Male Fertility: Beyond Heart Consequences of a Complex Cardiometabolic Endocrinopathy
Metabolic syndrome (MetS) is a highly prevalent condition among adult males, affecting up to 41% of men in Europe. It is characterized by the association of obesity, hypertension, and atherogenic dyslipidemia, which lead to premature morbidity and mortality due to cardiovascular disease (CVD). Male...
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MDPI AG
2022-05-01
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author | Gianmaria Salvio Alessandro Ciarloni Melissa Cutini Nicola delli Muti Federica Finocchi Michele Perrone Silvia Rossi Giancarlo Balercia |
author_facet | Gianmaria Salvio Alessandro Ciarloni Melissa Cutini Nicola delli Muti Federica Finocchi Michele Perrone Silvia Rossi Giancarlo Balercia |
author_sort | Gianmaria Salvio |
collection | DOAJ |
description | Metabolic syndrome (MetS) is a highly prevalent condition among adult males, affecting up to 41% of men in Europe. It is characterized by the association of obesity, hypertension, and atherogenic dyslipidemia, which lead to premature morbidity and mortality due to cardiovascular disease (CVD). Male infertility is another common condition which accounts for about 50% of cases of couple infertility worldwide. Interestingly, male infertility and MetS shares several risk factors (e.g., smoking, ageing, physical inactivity, and excessive alcohol consumption), leading to reactive oxygen species (ROS) production and increased oxidative stress (OS), and resulting in endothelial dysfunction and altered semen quality. Thus, the present narrative review aims to discuss the pathophysiological mechanisms which link male infertility and MetS and to investigate the latest available evidence on the reproductive consequences of MetS. |
first_indexed | 2024-03-10T03:44:09Z |
format | Article |
id | doaj.art-20e5d9979f8c47e8bc2df394b00479d2 |
institution | Directory Open Access Journal |
issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-10T03:44:09Z |
publishDate | 2022-05-01 |
publisher | MDPI AG |
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series | International Journal of Molecular Sciences |
spelling | doaj.art-20e5d9979f8c47e8bc2df394b00479d22023-11-23T11:23:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-012310549710.3390/ijms23105497Metabolic Syndrome and Male Fertility: Beyond Heart Consequences of a Complex Cardiometabolic EndocrinopathyGianmaria Salvio0Alessandro Ciarloni1Melissa Cutini2Nicola delli Muti3Federica Finocchi4Michele Perrone5Silvia Rossi6Giancarlo Balercia7Division of Endocrinology, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, 60126 Ancona, ItalyDivision of Endocrinology, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, 60126 Ancona, ItalyDivision of Endocrinology, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, 60126 Ancona, ItalyDivision of Endocrinology, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, 60126 Ancona, ItalyDivision of Endocrinology, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, 60126 Ancona, ItalyDivision of Endocrinology, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, 60126 Ancona, ItalyDivision of Endocrinology, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, 60126 Ancona, ItalyDivision of Endocrinology, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, 60126 Ancona, ItalyMetabolic syndrome (MetS) is a highly prevalent condition among adult males, affecting up to 41% of men in Europe. It is characterized by the association of obesity, hypertension, and atherogenic dyslipidemia, which lead to premature morbidity and mortality due to cardiovascular disease (CVD). Male infertility is another common condition which accounts for about 50% of cases of couple infertility worldwide. Interestingly, male infertility and MetS shares several risk factors (e.g., smoking, ageing, physical inactivity, and excessive alcohol consumption), leading to reactive oxygen species (ROS) production and increased oxidative stress (OS), and resulting in endothelial dysfunction and altered semen quality. Thus, the present narrative review aims to discuss the pathophysiological mechanisms which link male infertility and MetS and to investigate the latest available evidence on the reproductive consequences of MetS.https://www.mdpi.com/1422-0067/23/10/5497couple infertilitysterilitysperm qualityabnormal semen analysisoverweightobesity |
spellingShingle | Gianmaria Salvio Alessandro Ciarloni Melissa Cutini Nicola delli Muti Federica Finocchi Michele Perrone Silvia Rossi Giancarlo Balercia Metabolic Syndrome and Male Fertility: Beyond Heart Consequences of a Complex Cardiometabolic Endocrinopathy International Journal of Molecular Sciences couple infertility sterility sperm quality abnormal semen analysis overweight obesity |
title | Metabolic Syndrome and Male Fertility: Beyond Heart Consequences of a Complex Cardiometabolic Endocrinopathy |
title_full | Metabolic Syndrome and Male Fertility: Beyond Heart Consequences of a Complex Cardiometabolic Endocrinopathy |
title_fullStr | Metabolic Syndrome and Male Fertility: Beyond Heart Consequences of a Complex Cardiometabolic Endocrinopathy |
title_full_unstemmed | Metabolic Syndrome and Male Fertility: Beyond Heart Consequences of a Complex Cardiometabolic Endocrinopathy |
title_short | Metabolic Syndrome and Male Fertility: Beyond Heart Consequences of a Complex Cardiometabolic Endocrinopathy |
title_sort | metabolic syndrome and male fertility beyond heart consequences of a complex cardiometabolic endocrinopathy |
topic | couple infertility sterility sperm quality abnormal semen analysis overweight obesity |
url | https://www.mdpi.com/1422-0067/23/10/5497 |
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