Therapeutic Advancements in the Endovascular Management of Acute Ischemic Stroke
Stroke is the major cause of disability and the second leading cause of death worldwide. Acute ischemic stroke is responsible for ∼85% of all strokes, with 24% to 46% attributable to large‐vessel occlusion, which are typically associated with worse outcomes. Although the initial efforts to develop e...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-11-01
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| Series: | Stroke: Vascular and Interventional Neurology |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/SVIN.121.000168 |
| _version_ | 1797371963372470272 |
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| author | Mahmoud H. Mohammaden Diogo C. Haussen Raul G. Nogueira |
| author_facet | Mahmoud H. Mohammaden Diogo C. Haussen Raul G. Nogueira |
| author_sort | Mahmoud H. Mohammaden |
| collection | DOAJ |
| description | Stroke is the major cause of disability and the second leading cause of death worldwide. Acute ischemic stroke is responsible for ∼85% of all strokes, with 24% to 46% attributable to large‐vessel occlusion, which are typically associated with worse outcomes. Although the initial efforts to develop endovascular treatment for acute ischemic stroke took place over 6 decades ago, critical gaps in device technology and treatment selection existed, resulting in 3 failed randomized clinical trials published in 2013. Fortunately, devices and techniques have dramatically evolved over the past decade, leading to significant improvements in the safety, speed, and completeness of reperfusion. Since 2015, a total of 9 randomized trials have consistently demonstrated an overwhelming benefit to endovascular reperfusion. In this article, we will review the evolution of endovascular treatment for acute ischemic stroke, including the technical and technological advances as well as the perspectives in terms of patient selection and procedural and clinical outcomes of the landmark past and recent trials. |
| first_indexed | 2024-03-08T18:28:25Z |
| format | Article |
| id | doaj.art-20e8661fbbfa49658d84e05dee27914d |
| institution | Directory Open Access Journal |
| issn | 2694-5746 |
| language | English |
| last_indexed | 2024-03-08T18:28:25Z |
| publishDate | 2021-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke: Vascular and Interventional Neurology |
| spelling | doaj.art-20e8661fbbfa49658d84e05dee27914d2023-12-30T07:08:45ZengWileyStroke: Vascular and Interventional Neurology2694-57462021-11-011110.1161/SVIN.121.000168Therapeutic Advancements in the Endovascular Management of Acute Ischemic StrokeMahmoud H. Mohammaden0Diogo C. Haussen1Raul G. Nogueira2Marcus Stroke & Neuroscience Center Grady Memorial Hospital, and Department of Neurology Emory University School of Medicine Atlanta GAMarcus Stroke & Neuroscience Center Grady Memorial Hospital, and Department of Neurology Emory University School of Medicine Atlanta GAMarcus Stroke & Neuroscience Center Grady Memorial Hospital, and Department of Neurology Emory University School of Medicine Atlanta GAStroke is the major cause of disability and the second leading cause of death worldwide. Acute ischemic stroke is responsible for ∼85% of all strokes, with 24% to 46% attributable to large‐vessel occlusion, which are typically associated with worse outcomes. Although the initial efforts to develop endovascular treatment for acute ischemic stroke took place over 6 decades ago, critical gaps in device technology and treatment selection existed, resulting in 3 failed randomized clinical trials published in 2013. Fortunately, devices and techniques have dramatically evolved over the past decade, leading to significant improvements in the safety, speed, and completeness of reperfusion. Since 2015, a total of 9 randomized trials have consistently demonstrated an overwhelming benefit to endovascular reperfusion. In this article, we will review the evolution of endovascular treatment for acute ischemic stroke, including the technical and technological advances as well as the perspectives in terms of patient selection and procedural and clinical outcomes of the landmark past and recent trials.https://www.ahajournals.org/doi/10.1161/SVIN.121.000168clinical trialsendovascular treatmentmechanical thrombectomystroke |
| spellingShingle | Mahmoud H. Mohammaden Diogo C. Haussen Raul G. Nogueira Therapeutic Advancements in the Endovascular Management of Acute Ischemic Stroke Stroke: Vascular and Interventional Neurology clinical trials endovascular treatment mechanical thrombectomy stroke |
| title | Therapeutic Advancements in the Endovascular Management of Acute Ischemic Stroke |
| title_full | Therapeutic Advancements in the Endovascular Management of Acute Ischemic Stroke |
| title_fullStr | Therapeutic Advancements in the Endovascular Management of Acute Ischemic Stroke |
| title_full_unstemmed | Therapeutic Advancements in the Endovascular Management of Acute Ischemic Stroke |
| title_short | Therapeutic Advancements in the Endovascular Management of Acute Ischemic Stroke |
| title_sort | therapeutic advancements in the endovascular management of acute ischemic stroke |
| topic | clinical trials endovascular treatment mechanical thrombectomy stroke |
| url | https://www.ahajournals.org/doi/10.1161/SVIN.121.000168 |
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