Desymmetrization of Prochiral <i>N</i>-Pyrazolyl Maleimides via Organocatalyzed Asymmetric Michael Addition with Pyrazolones: Construction of Tri-<i>N</i>-Heterocyclic Scaffolds Bearing Both Central and Axial Chirality
The desymmetrization of <i>N</i>-pyrazolyl maleimides was realized through an asymmetric Michael addition by using pyrazolones under mild conditions, leading to the formation of a tri-<i>N</i>-heterocyclic pyrazole–succinimide–pyrazolone assembly in high yields with excellent...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/11/4279 |