Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis
The study aimed to reveal pregabalin’s median effective analgesic dose (ED<sub>50</sub>) and determine the type of analgesic interaction with tramadol, diclofenac, and paracetamol in chicks. The electrical stimulator device was used to detect pain before and after treatment, and through...
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| Format: | Article |
| Language: | Arabic |
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University of Mosul, College of Veterinary Medicine
2022-10-01
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| Series: | Iraqi Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | https://www.vetmedmosul.com/article_173321_7e3d0f25bd41275d195e03fef1a91959.pdf |
| _version_ | 1828327293528834048 |
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| author | Qutaiba M. Mohammed Yasser M. Albadrany |
| author_facet | Qutaiba M. Mohammed Yasser M. Albadrany |
| author_sort | Qutaiba M. Mohammed |
| collection | DOAJ |
| description | The study aimed to reveal pregabalin’s median effective analgesic dose (ED<sub>50</sub>) and determine the type of analgesic interaction with tramadol, diclofenac, and paracetamol in chicks. The electrical stimulator device was used to detect pain before and after treatment, and through ascending and descending in doses and depending on the up and down method, the median effective analgesic doses were determined for all drugs used in the study, and then the interaction experiment was conducted at a fixed ratio 0.5:0.5 of pregabalin with each of tramadol, diclofenac and paracetamol of their individual ED<sub>50</sub> values, the results were subjected to the isobolographic analysis to determine the type of interaction. Results showed that ED<sub>50s</sub> for pregabalin, tramadol, diclofenac, and paracetamol in chicks were 156.5, 0.82, 5.65, and 10.74 mg/kg, respectively. Concomitant administration of drugs pregabalin: tramadol, pregabalin: diclofenac and pregabalin: paracetamol at a fixed ratio 0.5:0.5 of their individual ED<sub>50</sub> values reduced their ED<sub>50s</sub> to 36.2:0.18, 64.3:2.3 and 64.3:4.3 mg/kg respectively. Isobolographic analysis showed synergistic analgesic effects of both drugs interaction. The calculated interaction indexes were 0.45, 0.81, and 0.81, respectively. We conclude from the outcomes that the analgesic interaction was synergistic between pregabalin and tramadol significantly, while the analgesic interaction of pregabalin with both diclofenac and paracetamol was also synergistic, but to a lesser extent. |
| first_indexed | 2024-04-13T19:52:30Z |
| format | Article |
| id | doaj.art-20eb8d88be2b448d9e936b4aab3c7677 |
| institution | Directory Open Access Journal |
| issn | 1607-3894 2071-1255 |
| language | Arabic |
| last_indexed | 2024-04-13T19:52:30Z |
| publishDate | 2022-10-01 |
| publisher | University of Mosul, College of Veterinary Medicine |
| record_format | Article |
| series | Iraqi Journal of Veterinary Sciences |
| spelling | doaj.art-20eb8d88be2b448d9e936b4aab3c76772022-12-22T02:32:27ZaraUniversity of Mosul, College of Veterinary MedicineIraqi Journal of Veterinary Sciences1607-38942071-12552022-10-0136493193710.33899/ijvs.2022.132586.2108173321Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysisQutaiba M. Mohammed0Yasser M. Albadrany1Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, IraqDepartment of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, IraqThe study aimed to reveal pregabalin’s median effective analgesic dose (ED<sub>50</sub>) and determine the type of analgesic interaction with tramadol, diclofenac, and paracetamol in chicks. The electrical stimulator device was used to detect pain before and after treatment, and through ascending and descending in doses and depending on the up and down method, the median effective analgesic doses were determined for all drugs used in the study, and then the interaction experiment was conducted at a fixed ratio 0.5:0.5 of pregabalin with each of tramadol, diclofenac and paracetamol of their individual ED<sub>50</sub> values, the results were subjected to the isobolographic analysis to determine the type of interaction. Results showed that ED<sub>50s</sub> for pregabalin, tramadol, diclofenac, and paracetamol in chicks were 156.5, 0.82, 5.65, and 10.74 mg/kg, respectively. Concomitant administration of drugs pregabalin: tramadol, pregabalin: diclofenac and pregabalin: paracetamol at a fixed ratio 0.5:0.5 of their individual ED<sub>50</sub> values reduced their ED<sub>50s</sub> to 36.2:0.18, 64.3:2.3 and 64.3:4.3 mg/kg respectively. Isobolographic analysis showed synergistic analgesic effects of both drugs interaction. The calculated interaction indexes were 0.45, 0.81, and 0.81, respectively. We conclude from the outcomes that the analgesic interaction was synergistic between pregabalin and tramadol significantly, while the analgesic interaction of pregabalin with both diclofenac and paracetamol was also synergistic, but to a lesser extent.https://www.vetmedmosul.com/article_173321_7e3d0f25bd41275d195e03fef1a91959.pdfpregabalinanalgesiaisobolographic analysischicks |
| spellingShingle | Qutaiba M. Mohammed Yasser M. Albadrany Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis Iraqi Journal of Veterinary Sciences pregabalin analgesia isobolographic analysis chicks |
| title | Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis |
| title_full | Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis |
| title_fullStr | Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis |
| title_full_unstemmed | Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis |
| title_short | Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis |
| title_sort | pregabalin potentiates the analgesic effect of tramadol diclofenac and paracetamol in chicks isobolographic analysis |
| topic | pregabalin analgesia isobolographic analysis chicks |
| url | https://www.vetmedmosul.com/article_173321_7e3d0f25bd41275d195e03fef1a91959.pdf |
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