60 Derivation and Validation of a Novel Hospital Capability Score for Sepsis
OBJECTIVES/GOALS: Regionalized sepsis care could improve sepsis outcomes. There are no measures of sepsis capability to guide the identification of hospitals that can best serve sepsis patients. We derived Capability-Based (CB) scores from specific hospital characteristics and evaluated their perfor...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2023-04-01
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| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866123001486/type/journal_article |
| _version_ | 1827960732706144256 |
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| author | Uchenna Ofoma Elena Deych Fei Wan Marin Kollef Karen Joynt Maddox |
| author_facet | Uchenna Ofoma Elena Deych Fei Wan Marin Kollef Karen Joynt Maddox |
| author_sort | Uchenna Ofoma |
| collection | DOAJ |
| description | OBJECTIVES/GOALS: Regionalized sepsis care could improve sepsis outcomes. There are no measures of sepsis capability to guide the identification of hospitals that can best serve sepsis patients. We derived Capability-Based (CB) scores from specific hospital characteristics and evaluated their performance as system predictors of mortality among adults with sepsis. METHODS/STUDY POPULATION: We used the 2018 State Inpatient Databases to identify 90051 adult sepsis encounters at 157 non-federal NY hospitals (derivation cohort), and 130,249 sepsis encounters at 220 hospitals in FL and MA (validation cohort). We used Principal Component Analysis to analyze to reduce 14 hospital-level resource use characteristics to 3 interpretable, linear data combinations (principal components (PC). We calculated CB scores for each hospital as a sum of standardized values for each component multiplied by the respective PC loading. We evaluated the correlation of sepsis volume and each CB score with hospital mortality and with outward sepsis transfer proportions. We fitted linear, nested, predictive models to compare the system predictive abilities of CB scores and sepsis volume in relation to hospital mortality. RESULTS/ANTICIPATED RESULTS: In the derivation cohort, 83963 (93.2%) patients were non-transferred, of which 20230 (24.1%) died. The mean (range) score was 0 (-3 - +5) with higher scores denoting more capable hospitals. Higher scores were weakly and inversely correlated (spearman’s [r]: - 0.28) with outward sepsis transfer proportions. Higher scores had weak but better positive correlation with hospital mortality (r: 0.33), than sepsis volume (r: 0.24). CB scores explained more variation in sepsis mortality (R2 = 0.24, P DISCUSSION/SIGNIFICANCE: Capability-based hospital scores account for three times more variation in sepsis mortality than sepsis volume and outperform sepsis volume as a system predictor of mortality. With further refinement and validation, these scores may find utility for improving system-based approaches to sepsis care. |
| first_indexed | 2024-04-09T16:14:15Z |
| format | Article |
| id | doaj.art-20ecf7e8b4114bf9bcb8bc899b2d5fe1 |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-09T16:14:15Z |
| publishDate | 2023-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-20ecf7e8b4114bf9bcb8bc899b2d5fe12023-04-24T05:55:57ZengCambridge University PressJournal of Clinical and Translational Science2059-86612023-04-017161610.1017/cts.2023.14860 Derivation and Validation of a Novel Hospital Capability Score for SepsisUchenna Ofoma0Elena Deych1Fei Wan2Marin Kollef3Karen Joynt Maddox4Washington University in Saint LouisWashington University in Saint LouisWashington University in Saint LouisWashington University in Saint LouisWashington University in Saint LouisOBJECTIVES/GOALS: Regionalized sepsis care could improve sepsis outcomes. There are no measures of sepsis capability to guide the identification of hospitals that can best serve sepsis patients. We derived Capability-Based (CB) scores from specific hospital characteristics and evaluated their performance as system predictors of mortality among adults with sepsis. METHODS/STUDY POPULATION: We used the 2018 State Inpatient Databases to identify 90051 adult sepsis encounters at 157 non-federal NY hospitals (derivation cohort), and 130,249 sepsis encounters at 220 hospitals in FL and MA (validation cohort). We used Principal Component Analysis to analyze to reduce 14 hospital-level resource use characteristics to 3 interpretable, linear data combinations (principal components (PC). We calculated CB scores for each hospital as a sum of standardized values for each component multiplied by the respective PC loading. We evaluated the correlation of sepsis volume and each CB score with hospital mortality and with outward sepsis transfer proportions. We fitted linear, nested, predictive models to compare the system predictive abilities of CB scores and sepsis volume in relation to hospital mortality. RESULTS/ANTICIPATED RESULTS: In the derivation cohort, 83963 (93.2%) patients were non-transferred, of which 20230 (24.1%) died. The mean (range) score was 0 (-3 - +5) with higher scores denoting more capable hospitals. Higher scores were weakly and inversely correlated (spearman’s [r]: - 0.28) with outward sepsis transfer proportions. Higher scores had weak but better positive correlation with hospital mortality (r: 0.33), than sepsis volume (r: 0.24). CB scores explained more variation in sepsis mortality (R2 = 0.24, P DISCUSSION/SIGNIFICANCE: Capability-based hospital scores account for three times more variation in sepsis mortality than sepsis volume and outperform sepsis volume as a system predictor of mortality. With further refinement and validation, these scores may find utility for improving system-based approaches to sepsis care.https://www.cambridge.org/core/product/identifier/S2059866123001486/type/journal_article |
| spellingShingle | Uchenna Ofoma Elena Deych Fei Wan Marin Kollef Karen Joynt Maddox 60 Derivation and Validation of a Novel Hospital Capability Score for Sepsis Journal of Clinical and Translational Science |
| title | 60 Derivation and Validation of a Novel Hospital Capability Score for Sepsis |
| title_full | 60 Derivation and Validation of a Novel Hospital Capability Score for Sepsis |
| title_fullStr | 60 Derivation and Validation of a Novel Hospital Capability Score for Sepsis |
| title_full_unstemmed | 60 Derivation and Validation of a Novel Hospital Capability Score for Sepsis |
| title_short | 60 Derivation and Validation of a Novel Hospital Capability Score for Sepsis |
| title_sort | 60 derivation and validation of a novel hospital capability score for sepsis |
| url | https://www.cambridge.org/core/product/identifier/S2059866123001486/type/journal_article |
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