PGC-1s in the Spotlight with Parkinson’s Disease
Parkinson’s disease is one of the most common neurodegenerative disorders worldwide, characterized by a progressive loss of dopaminergic neurons mainly localized in the <i>substantia nigra pars compacta</i>. In recent years, the detailed analyses of both genetic and idiopathic forms of t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/7/3487 |
| _version_ | 1797539733246574592 |
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| author | Elena Piccinin Anna Maria Sardanelli Peter Seibel Antonio Moschetta Tiziana Cocco Gaetano Villani |
| author_facet | Elena Piccinin Anna Maria Sardanelli Peter Seibel Antonio Moschetta Tiziana Cocco Gaetano Villani |
| author_sort | Elena Piccinin |
| collection | DOAJ |
| description | Parkinson’s disease is one of the most common neurodegenerative disorders worldwide, characterized by a progressive loss of dopaminergic neurons mainly localized in the <i>substantia nigra pars compacta</i>. In recent years, the detailed analyses of both genetic and idiopathic forms of the disease have led to a better understanding of the molecular and cellular pathways involved in PD, pointing to the centrality of mitochondrial dysfunctions in the pathogenic process. Failure of mitochondrial quality control is now considered a hallmark of the disease. The peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1) family acts as a master regulator of mitochondrial biogenesis. Therefore, keeping PGC-1 level in a proper range is fundamental to guarantee functional neurons. Here we review the major findings that tightly bond PD and PGC-1s, raising important points that might lead to future investigations. |
| first_indexed | 2024-03-10T12:50:02Z |
| format | Article |
| id | doaj.art-20ecfa232a634830b5554ae189905536 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:50:02Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-20ecfa232a634830b5554ae1899055362023-11-21T13:07:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01227348710.3390/ijms22073487PGC-1s in the Spotlight with Parkinson’s DiseaseElena Piccinin0Anna Maria Sardanelli1Peter Seibel2Antonio Moschetta3Tiziana Cocco4Gaetano Villani5Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari “Aldo Moro”, 70124 Bari, ItalyMolecular Cell Therapy, BBZ, Medical Faculty, University of Leipzig, Deutscher Platz 5, 04103 Leipzig, GermanyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari “Aldo Moro”, 70124 Bari, ItalyParkinson’s disease is one of the most common neurodegenerative disorders worldwide, characterized by a progressive loss of dopaminergic neurons mainly localized in the <i>substantia nigra pars compacta</i>. In recent years, the detailed analyses of both genetic and idiopathic forms of the disease have led to a better understanding of the molecular and cellular pathways involved in PD, pointing to the centrality of mitochondrial dysfunctions in the pathogenic process. Failure of mitochondrial quality control is now considered a hallmark of the disease. The peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1) family acts as a master regulator of mitochondrial biogenesis. Therefore, keeping PGC-1 level in a proper range is fundamental to guarantee functional neurons. Here we review the major findings that tightly bond PD and PGC-1s, raising important points that might lead to future investigations.https://www.mdpi.com/1422-0067/22/7/3487PGC-1coactivatorsneurodegenerative diseaseParkinson’s diseasemitochondria |
| spellingShingle | Elena Piccinin Anna Maria Sardanelli Peter Seibel Antonio Moschetta Tiziana Cocco Gaetano Villani PGC-1s in the Spotlight with Parkinson’s Disease International Journal of Molecular Sciences PGC-1 coactivators neurodegenerative disease Parkinson’s disease mitochondria |
| title | PGC-1s in the Spotlight with Parkinson’s Disease |
| title_full | PGC-1s in the Spotlight with Parkinson’s Disease |
| title_fullStr | PGC-1s in the Spotlight with Parkinson’s Disease |
| title_full_unstemmed | PGC-1s in the Spotlight with Parkinson’s Disease |
| title_short | PGC-1s in the Spotlight with Parkinson’s Disease |
| title_sort | pgc 1s in the spotlight with parkinson s disease |
| topic | PGC-1 coactivators neurodegenerative disease Parkinson’s disease mitochondria |
| url | https://www.mdpi.com/1422-0067/22/7/3487 |
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