MYTHO is a novel regulator of skeletal muscle autophagy and integrity
Here, the authors identify a novel regulator of autophagy, skeletal muscle mass and integrity named MYTHO. Silencing MYTHO protects against muscle atrophy in a wide range of acute catabolic conditions, while prolonged silencing causes a severe myopathy.
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36817-1 |
| _version_ | 1827983508574830592 |
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| author | Jean-Philippe Leduc-Gaudet Anais Franco-Romero Marina Cefis Alaa Moamer Felipe E. Broering Giulia Milan Roberta Sartori Tomer Jordi Chaffer Maude Dulac Vincent Marcangeli Dominique Mayaki Laurent Huck Anwar Shams José A. Morais Elise Duchesne Hanns Lochmuller Marco Sandri Sabah N. A. Hussain Gilles Gouspillou |
| author_facet | Jean-Philippe Leduc-Gaudet Anais Franco-Romero Marina Cefis Alaa Moamer Felipe E. Broering Giulia Milan Roberta Sartori Tomer Jordi Chaffer Maude Dulac Vincent Marcangeli Dominique Mayaki Laurent Huck Anwar Shams José A. Morais Elise Duchesne Hanns Lochmuller Marco Sandri Sabah N. A. Hussain Gilles Gouspillou |
| author_sort | Jean-Philippe Leduc-Gaudet |
| collection | DOAJ |
| description | Here, the authors identify a novel regulator of autophagy, skeletal muscle mass and integrity named MYTHO. Silencing MYTHO protects against muscle atrophy in a wide range of acute catabolic conditions, while prolonged silencing causes a severe myopathy. |
| first_indexed | 2024-04-09T22:49:04Z |
| format | Article |
| id | doaj.art-20ed78ff3f19495c9028668e5c96dfd4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:49:04Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-20ed78ff3f19495c9028668e5c96dfd42023-03-22T11:42:01ZengNature PortfolioNature Communications2041-17232023-03-0114112010.1038/s41467-023-36817-1MYTHO is a novel regulator of skeletal muscle autophagy and integrityJean-Philippe Leduc-Gaudet0Anais Franco-Romero1Marina Cefis2Alaa Moamer3Felipe E. Broering4Giulia Milan5Roberta Sartori6Tomer Jordi Chaffer7Maude Dulac8Vincent Marcangeli9Dominique Mayaki10Laurent Huck11Anwar Shams12José A. Morais13Elise Duchesne14Hanns Lochmuller15Marco Sandri16Sabah N. A. Hussain17Gilles Gouspillou18Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health CentreVeneto Institute of Molecular MedicineDépartement des Sciences de l’Activité Physique, Faculté des Sciences, Université du Québec à MontréalMeakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health CentreMeakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health CentreVeneto Institute of Molecular MedicineVeneto Institute of Molecular MedicineMeakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health CentreDépartement des Sciences de l’Activité Physique, Faculté des Sciences, Université du Québec à MontréalDépartement des Sciences de l’Activité Physique, Faculté des Sciences, Université du Québec à MontréalMeakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health CentreMeakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health CentreDepartment of Pharmacology, College of Medicine, Taif UniversityDivision of Geriatric Medicine, MUHC-Montreal General Hospital, McGill UniversityDépartement des Sciences de la Santé, Unité d’Enseignement en Physiothérapie, Université du Québec à ChicoutimiChildren’s Hospital of Eastern Ontario Research InstituteDepartment of Critical Care, McGill University Health CentreMeakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health CentreMeakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health CentreHere, the authors identify a novel regulator of autophagy, skeletal muscle mass and integrity named MYTHO. Silencing MYTHO protects against muscle atrophy in a wide range of acute catabolic conditions, while prolonged silencing causes a severe myopathy.https://doi.org/10.1038/s41467-023-36817-1 |
| spellingShingle | Jean-Philippe Leduc-Gaudet Anais Franco-Romero Marina Cefis Alaa Moamer Felipe E. Broering Giulia Milan Roberta Sartori Tomer Jordi Chaffer Maude Dulac Vincent Marcangeli Dominique Mayaki Laurent Huck Anwar Shams José A. Morais Elise Duchesne Hanns Lochmuller Marco Sandri Sabah N. A. Hussain Gilles Gouspillou MYTHO is a novel regulator of skeletal muscle autophagy and integrity Nature Communications |
| title | MYTHO is a novel regulator of skeletal muscle autophagy and integrity |
| title_full | MYTHO is a novel regulator of skeletal muscle autophagy and integrity |
| title_fullStr | MYTHO is a novel regulator of skeletal muscle autophagy and integrity |
| title_full_unstemmed | MYTHO is a novel regulator of skeletal muscle autophagy and integrity |
| title_short | MYTHO is a novel regulator of skeletal muscle autophagy and integrity |
| title_sort | mytho is a novel regulator of skeletal muscle autophagy and integrity |
| url | https://doi.org/10.1038/s41467-023-36817-1 |
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