Maternal supplementation with a casein hydrolysate and yeast beta-glucan from late gestation through lactation improves gastrointestinal health of piglets at weaning
Abstract Improving maternal nutrition during pregnancy/lactation is a promising strategy to maximise the intestinal health of piglets undergoing abrupt weaning under commercial production conditions. This experiment investigated the effects of maternal supplementation of a casein hydrolysate and yea...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-20723-5 |
| _version_ | 1797985946464944128 |
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| author | Alison Dowley John V. O’Doherty Anindya Mukhopadhya Eadaoin Conway Stafford Vigors Shane Maher Marion T. Ryan Torres Sweeney |
| author_facet | Alison Dowley John V. O’Doherty Anindya Mukhopadhya Eadaoin Conway Stafford Vigors Shane Maher Marion T. Ryan Torres Sweeney |
| author_sort | Alison Dowley |
| collection | DOAJ |
| description | Abstract Improving maternal nutrition during pregnancy/lactation is a promising strategy to maximise the intestinal health of piglets undergoing abrupt weaning under commercial production conditions. This experiment investigated the effects of maternal supplementation of a casein hydrolysate and yeast β-glucan (CH-YBG) from day 83 of gestation until weaning (day 28) on sow faecal microbial populations and measures of piglet gastrointestinal health parameters at weaning. Sows (n = 10 sows/group) were assigned to: (1) control diet, and (2) control diet + CH-YBG. Maternal supplementation increased the abundance of the phylum Firmicutes, including members Lactobacillus in the sows faeces, with a concomitant increase in the caecal abundance of Lactobacillus in the weaned piglets compared to the controls. Piglets weaned from the supplemented sows had increased villus height in the duodenum (P < 0.05) and increased villus height to crypt depth ratio in the jejunum, as well as a decreased expression of the proinflammatory cytokine genes (IL6/TNF/TGFB), the tight junction gene CLDN3 and the mucin gene MUC2 in the duodenum/jejunum compared to the controls (P < 0.05). In conclusion, maternal CH-YBG supplementation during pregnancy/lactation improved microbial, structural, and inflammatory measures of gastrointestinal health of piglets at weaning. This is a promising strategy to alleviate the challenges that occur with early abrupt weaning in commercial pig production. |
| first_indexed | 2024-04-11T07:26:10Z |
| format | Article |
| id | doaj.art-20ed9e4280c347cfa60e6bcedf517725 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T07:26:10Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-20ed9e4280c347cfa60e6bcedf5177252022-12-22T04:37:04ZengNature PortfolioScientific Reports2045-23222022-10-0112111410.1038/s41598-022-20723-5Maternal supplementation with a casein hydrolysate and yeast beta-glucan from late gestation through lactation improves gastrointestinal health of piglets at weaningAlison Dowley0John V. O’Doherty1Anindya Mukhopadhya2Eadaoin Conway3Stafford Vigors4Shane Maher5Marion T. Ryan6Torres Sweeney7School of Agriculture and Food Science, University College DublinSchool of Agriculture and Food Science, University College DublinSchool of Veterinary Medicine, University College DublinSchool of Agriculture and Food Science, University College DublinSchool of Agriculture and Food Science, University College DublinSchool of Agriculture and Food Science, University College DublinSchool of Veterinary Medicine, University College DublinSchool of Veterinary Medicine, University College DublinAbstract Improving maternal nutrition during pregnancy/lactation is a promising strategy to maximise the intestinal health of piglets undergoing abrupt weaning under commercial production conditions. This experiment investigated the effects of maternal supplementation of a casein hydrolysate and yeast β-glucan (CH-YBG) from day 83 of gestation until weaning (day 28) on sow faecal microbial populations and measures of piglet gastrointestinal health parameters at weaning. Sows (n = 10 sows/group) were assigned to: (1) control diet, and (2) control diet + CH-YBG. Maternal supplementation increased the abundance of the phylum Firmicutes, including members Lactobacillus in the sows faeces, with a concomitant increase in the caecal abundance of Lactobacillus in the weaned piglets compared to the controls. Piglets weaned from the supplemented sows had increased villus height in the duodenum (P < 0.05) and increased villus height to crypt depth ratio in the jejunum, as well as a decreased expression of the proinflammatory cytokine genes (IL6/TNF/TGFB), the tight junction gene CLDN3 and the mucin gene MUC2 in the duodenum/jejunum compared to the controls (P < 0.05). In conclusion, maternal CH-YBG supplementation during pregnancy/lactation improved microbial, structural, and inflammatory measures of gastrointestinal health of piglets at weaning. This is a promising strategy to alleviate the challenges that occur with early abrupt weaning in commercial pig production.https://doi.org/10.1038/s41598-022-20723-5 |
| spellingShingle | Alison Dowley John V. O’Doherty Anindya Mukhopadhya Eadaoin Conway Stafford Vigors Shane Maher Marion T. Ryan Torres Sweeney Maternal supplementation with a casein hydrolysate and yeast beta-glucan from late gestation through lactation improves gastrointestinal health of piglets at weaning Scientific Reports |
| title | Maternal supplementation with a casein hydrolysate and yeast beta-glucan from late gestation through lactation improves gastrointestinal health of piglets at weaning |
| title_full | Maternal supplementation with a casein hydrolysate and yeast beta-glucan from late gestation through lactation improves gastrointestinal health of piglets at weaning |
| title_fullStr | Maternal supplementation with a casein hydrolysate and yeast beta-glucan from late gestation through lactation improves gastrointestinal health of piglets at weaning |
| title_full_unstemmed | Maternal supplementation with a casein hydrolysate and yeast beta-glucan from late gestation through lactation improves gastrointestinal health of piglets at weaning |
| title_short | Maternal supplementation with a casein hydrolysate and yeast beta-glucan from late gestation through lactation improves gastrointestinal health of piglets at weaning |
| title_sort | maternal supplementation with a casein hydrolysate and yeast beta glucan from late gestation through lactation improves gastrointestinal health of piglets at weaning |
| url | https://doi.org/10.1038/s41598-022-20723-5 |
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