Histopathological Spectrum of Spinal Tumours at a Tertiary Care Hospital, Gujarat, India: A Retrospective Study
Introduction: The anatomic structures in the spinal area are diverse and unpredictable, often representing an excellent test for both the neuroclinicians and neuropathologists, thereby showing a broad heterogeneous spectrum of pathological lesions. Clinical history, radiological features, and pathol...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2023-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/17277/59217_CE(Vi)_F[SK]_PF1(PS_SL)_PF2(AKA_KM)_PFA(AKA_KM)_PN(KM).pdf |
| _version_ | 1797938373166366720 |
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| author | Khushbu Kantilal Tilva Urvi Parikh |
| author_facet | Khushbu Kantilal Tilva Urvi Parikh |
| author_sort | Khushbu Kantilal Tilva |
| collection | DOAJ |
| description | Introduction: The anatomic structures in the spinal area are diverse and unpredictable, often representing an excellent test for both the neuroclinicians and neuropathologists, thereby showing a broad heterogeneous spectrum of pathological lesions. Clinical history, radiological features, and pathological examination are required to diagnose spinal tumours.
Aim: To study the histopathological spectrum of spinal tumours in a tertiary care teaching hospital in Gujarat, India.
Materials and Methods: In this retrospective study, data was collected from the records of 100 patients who had spinal tumours and who attended the Department of Pathology. Histopathological diagnosis of the spinal biopsy specimen was the primary outcome variable. Age, gender, location of the tumour, and clinical features were other study relevant variables. The status of the spinal tumour (benign/malignant) was considered an explanatory variable. Descriptive analysis was carried out by mean and standard deviation for quantitative variables, frequency, and proportion for categorical variables. Categorical outcomes were compared using the Chi-square test.
Results: A total of 100 subjects were included, among which 42 participants were males, and 58 were females with the mean age 34.62±17.64 years. The maximum number of spinal tumours were noted in (21-30 year) 3rd decade (29%) of life. Benign spinal tumours (73%) were more common than malignant spinal tumours (27%). Schwannoma was the most common (37%) spinal tumour, followed by meningioma (20%), and ependymoma (14%). The distribution of spinal tumours based on anatomical location, 31% intradural intramedullary, 49% intradural extramedullary, and 20% extradural tumours. There was a significant difference between nerve sheath tumours and meningioma with gender (p-value <0.001).
Conclusion: The study identified schwannoma and meningiomas as the most common tumours. The thoracic region was the most frequently involved spinal level, followed by the cervical, and the most affected location was the intradural extramedullary. |
| first_indexed | 2024-04-10T18:59:48Z |
| format | Article |
| id | doaj.art-20ee99ba1e3443148526e7a59b40e325 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-10T18:59:48Z |
| publishDate | 2023-01-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-20ee99ba1e3443148526e7a59b40e3252023-01-31T10:00:28ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-01-01171EC05EC0910.7860/JCDR/2023/59217.17277Histopathological Spectrum of Spinal Tumours at a Tertiary Care Hospital, Gujarat, India: A Retrospective StudyKhushbu Kantilal Tilva0Urvi Parikh1Assistant Professor, Department of Pathology, P. D. U. Medical College and Hospital, Rajkot, Gujarat, India.Assistant Professor, Department of Pathology, B. J. Medical College, Ahmedabad, Gujarat, India.Introduction: The anatomic structures in the spinal area are diverse and unpredictable, often representing an excellent test for both the neuroclinicians and neuropathologists, thereby showing a broad heterogeneous spectrum of pathological lesions. Clinical history, radiological features, and pathological examination are required to diagnose spinal tumours. Aim: To study the histopathological spectrum of spinal tumours in a tertiary care teaching hospital in Gujarat, India. Materials and Methods: In this retrospective study, data was collected from the records of 100 patients who had spinal tumours and who attended the Department of Pathology. Histopathological diagnosis of the spinal biopsy specimen was the primary outcome variable. Age, gender, location of the tumour, and clinical features were other study relevant variables. The status of the spinal tumour (benign/malignant) was considered an explanatory variable. Descriptive analysis was carried out by mean and standard deviation for quantitative variables, frequency, and proportion for categorical variables. Categorical outcomes were compared using the Chi-square test. Results: A total of 100 subjects were included, among which 42 participants were males, and 58 were females with the mean age 34.62±17.64 years. The maximum number of spinal tumours were noted in (21-30 year) 3rd decade (29%) of life. Benign spinal tumours (73%) were more common than malignant spinal tumours (27%). Schwannoma was the most common (37%) spinal tumour, followed by meningioma (20%), and ependymoma (14%). The distribution of spinal tumours based on anatomical location, 31% intradural intramedullary, 49% intradural extramedullary, and 20% extradural tumours. There was a significant difference between nerve sheath tumours and meningioma with gender (p-value <0.001). Conclusion: The study identified schwannoma and meningiomas as the most common tumours. The thoracic region was the most frequently involved spinal level, followed by the cervical, and the most affected location was the intradural extramedullary.https://www.jcdr.net/articles/PDF/17277/59217_CE(Vi)_F[SK]_PF1(PS_SL)_PF2(AKA_KM)_PFA(AKA_KM)_PN(KM).pdfmeningiomaschwannomaspinal cord neoplasms |
| spellingShingle | Khushbu Kantilal Tilva Urvi Parikh Histopathological Spectrum of Spinal Tumours at a Tertiary Care Hospital, Gujarat, India: A Retrospective Study Journal of Clinical and Diagnostic Research meningioma schwannoma spinal cord neoplasms |
| title | Histopathological Spectrum of Spinal Tumours at a Tertiary Care Hospital, Gujarat, India: A Retrospective Study |
| title_full | Histopathological Spectrum of Spinal Tumours at a Tertiary Care Hospital, Gujarat, India: A Retrospective Study |
| title_fullStr | Histopathological Spectrum of Spinal Tumours at a Tertiary Care Hospital, Gujarat, India: A Retrospective Study |
| title_full_unstemmed | Histopathological Spectrum of Spinal Tumours at a Tertiary Care Hospital, Gujarat, India: A Retrospective Study |
| title_short | Histopathological Spectrum of Spinal Tumours at a Tertiary Care Hospital, Gujarat, India: A Retrospective Study |
| title_sort | histopathological spectrum of spinal tumours at a tertiary care hospital gujarat india a retrospective study |
| topic | meningioma schwannoma spinal cord neoplasms |
| url | https://www.jcdr.net/articles/PDF/17277/59217_CE(Vi)_F[SK]_PF1(PS_SL)_PF2(AKA_KM)_PFA(AKA_KM)_PN(KM).pdf |
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