Novel Small-Molecule Inhibitors of the SARS-CoV-2 Spike Protein Binding to Neuropilin 1
Furin cleavage of the SARS-CoV-2 spike protein results in a polybasic terminal sequence termed the C-end rule (CendR), which is responsible for the binding to neuropilin 1 (NRP1), enhancing viral infectivity and entry into the cell. Here we report the identification of 20 small-molecule inhibitors t...
Main Authors: | Anja Kolarič, Marko Jukič, Urban Bren |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-01-01
|
Series: | Pharmaceuticals |
Subjects: | |
Online Access: | https://www.mdpi.com/1424-8247/15/2/165 |
Similar Items
-
Neuropilin (NRPs) Related Pathological Conditions and Their Modulators
by: Matic Broz, et al.
Published: (2022-07-01) -
Conservation and Enhanced Binding of SARS-CoV-2 Omicron Spike Protein to Coreceptor Neuropilin-1 Predicted by Docking Analysis
by: Piyush Baindara, et al.
Published: (2022-03-01) -
VEGFA, B, C: Implications of the C-Terminal Sequence Variations for the Interaction with Neuropilins
by: Charles Eldrid, et al.
Published: (2022-02-01) -
Evaluation of the Cytotoxic and Antiviral Effects of Small Molecules Selected by In Silico Studies as Inhibitors of SARS-CoV-2 Cell Entry
by: Francisca Carvalhal, et al.
Published: (2023-10-01) -
Significance of Neuropilin-1 Expression in Acute Myeloid Leukemia
by: Tarif H. Sallam, et al.
Published: (2013-09-01)