Immunotherapeutic modalities for the treatment of recalcitrant plantar warts: a comparative study
Background Plantar warts are sometimes resistant or they tend to recur after every possible destructive therapy. Immunotherapy has been used as a promising alternative therapeutic option in such recalcitrant cases. Aim To evaluate and compare the efficacy and safety of the intralesional injection of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-02-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2020.1789540 |
| _version_ | 1797683547114307584 |
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| author | Ahmad Nofal Waleed Albalat Amira Ismail Fathia M. Khattab |
| author_facet | Ahmad Nofal Waleed Albalat Amira Ismail Fathia M. Khattab |
| author_sort | Ahmad Nofal |
| collection | DOAJ |
| description | Background Plantar warts are sometimes resistant or they tend to recur after every possible destructive therapy. Immunotherapy has been used as a promising alternative therapeutic option in such recalcitrant cases. Aim To evaluate and compare the efficacy and safety of the intralesional injection of vitamin D3, zinc sulfate 2%, and Candida antigen in the treatment of recalcitrant plantar warts. Patients and methods The study included 152 adult patients with single or multiple recalcitrant plantar warts. They were equally subdivided into four groups (38 patients in each): 2% zinc sulfate, vitamin D3, Candida antigen, and normal saline respectively. Injections were done at 3-week intervals until complete resolution or for a maximum of 4 sessions. Results Complete response was achieved in 20 patients (52.7%) of the zinc sulfate group, 34 patients (89.5%) of the intralesional vitamin D3 group, 25 patients (65.7%) of the intralesional Candida antigen group and 8 patients (21.2%) of the saline group. The difference between the groups was statistically significant in favor of vitamin D3 (p = .037). Conclusions Recalcitrant plantar warts were best treated with vitamin D3 that also has the advantages of better response on distant warts, minimal side effects, and low rate of wart recurrence. |
| first_indexed | 2024-03-12T00:16:40Z |
| format | Article |
| id | doaj.art-20efc61eafc04f5690e76fbd635087a8 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:16:40Z |
| publishDate | 2022-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-20efc61eafc04f5690e76fbd635087a82023-09-15T14:23:07ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-02-0133292292710.1080/09546634.2020.17895401789540Immunotherapeutic modalities for the treatment of recalcitrant plantar warts: a comparative studyAhmad Nofal0Waleed Albalat1Amira Ismail2Fathia M. Khattab3Dermatology Department, Faculty of Medicine, Zagazig UniversityDermatology Department, Faculty of Medicine, Zagazig UniversityDermatology Department, Faculty of Medicine, Zagazig UniversityDermatology Department, Faculty of Medicine, Zagazig UniversityBackground Plantar warts are sometimes resistant or they tend to recur after every possible destructive therapy. Immunotherapy has been used as a promising alternative therapeutic option in such recalcitrant cases. Aim To evaluate and compare the efficacy and safety of the intralesional injection of vitamin D3, zinc sulfate 2%, and Candida antigen in the treatment of recalcitrant plantar warts. Patients and methods The study included 152 adult patients with single or multiple recalcitrant plantar warts. They were equally subdivided into four groups (38 patients in each): 2% zinc sulfate, vitamin D3, Candida antigen, and normal saline respectively. Injections were done at 3-week intervals until complete resolution or for a maximum of 4 sessions. Results Complete response was achieved in 20 patients (52.7%) of the zinc sulfate group, 34 patients (89.5%) of the intralesional vitamin D3 group, 25 patients (65.7%) of the intralesional Candida antigen group and 8 patients (21.2%) of the saline group. The difference between the groups was statistically significant in favor of vitamin D3 (p = .037). Conclusions Recalcitrant plantar warts were best treated with vitamin D3 that also has the advantages of better response on distant warts, minimal side effects, and low rate of wart recurrence.http://dx.doi.org/10.1080/09546634.2020.1789540zinc sulfatevitamin d3candida antigenimmunotherapyplantar warts |
| spellingShingle | Ahmad Nofal Waleed Albalat Amira Ismail Fathia M. Khattab Immunotherapeutic modalities for the treatment of recalcitrant plantar warts: a comparative study Journal of Dermatological Treatment zinc sulfate vitamin d3 candida antigen immunotherapy plantar warts |
| title | Immunotherapeutic modalities for the treatment of recalcitrant plantar warts: a comparative study |
| title_full | Immunotherapeutic modalities for the treatment of recalcitrant plantar warts: a comparative study |
| title_fullStr | Immunotherapeutic modalities for the treatment of recalcitrant plantar warts: a comparative study |
| title_full_unstemmed | Immunotherapeutic modalities for the treatment of recalcitrant plantar warts: a comparative study |
| title_short | Immunotherapeutic modalities for the treatment of recalcitrant plantar warts: a comparative study |
| title_sort | immunotherapeutic modalities for the treatment of recalcitrant plantar warts a comparative study |
| topic | zinc sulfate vitamin d3 candida antigen immunotherapy plantar warts |
| url | http://dx.doi.org/10.1080/09546634.2020.1789540 |
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