Repeatability of simultaneous 3D 1H MRF/23Na MRI in brain at 7 T
Abstract Proton MRI can provide detailed morphological images, but it reveals little information about cell homeostasis. On the other hand, sodium MRI can provide metabolic information but cannot resolve fine structures. The complementary nature of proton and sodium MRI raises the prospect of their...
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| Format: | Article |
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Nature Portfolio
2022-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-18388-1 |
| _version_ | 1828150661838012416 |
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| author | Gonzalo G. Rodriguez Zidan Yu Lauren F. O′Donnell Liz Calderon Martijn A. Cloos Guillaume Madelin |
| author_facet | Gonzalo G. Rodriguez Zidan Yu Lauren F. O′Donnell Liz Calderon Martijn A. Cloos Guillaume Madelin |
| author_sort | Gonzalo G. Rodriguez |
| collection | DOAJ |
| description | Abstract Proton MRI can provide detailed morphological images, but it reveals little information about cell homeostasis. On the other hand, sodium MRI can provide metabolic information but cannot resolve fine structures. The complementary nature of proton and sodium MRI raises the prospect of their combined use in a single experiment. In this work, we assessed the repeatability of normalized proton density (PD), T1, T2, and normalized sodium density-weighted quantification measured with simultaneous 3D 1H MRF/23Na MRI in the brain at 7 T, from ten healthy volunteers who were scanned three times each. The coefficients of variation (CV) and the intra-class correlation (ICC) were calculated for the mean and standard deviation (SD) of these 4 parameters in grey matter, white matter, and cerebrospinal fluid. As result, the CVs were lower than 3.3% for the mean values and lower than 6.9% for the SD values. The ICCs were higher than 0.61 in all 24 measurements. We conclude that the measurements of normalized PD, T1, T2, and normalized sodium density-weighted from simultaneous 3D 1H MRF/23Na MRI in the brain at 7 T showed high repeatability. We estimate that changes > 6.6% (> 2 CVs) in mean values of both 1H and 23Na metrics could be detectable with this method. |
| first_indexed | 2024-04-11T21:46:28Z |
| format | Article |
| id | doaj.art-20f3668e75ef4d1b92dbb511deab247e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T21:46:28Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-20f3668e75ef4d1b92dbb511deab247e2022-12-22T04:01:24ZengNature PortfolioScientific Reports2045-23222022-08-011211910.1038/s41598-022-18388-1Repeatability of simultaneous 3D 1H MRF/23Na MRI in brain at 7 TGonzalo G. Rodriguez0Zidan Yu1Lauren F. O′Donnell2Liz Calderon3Martijn A. Cloos4Guillaume Madelin5Center for Biomedical Imaging, Department of Radiology, New York University Grossman School MedicineCenter for Biomedical Imaging, Department of Radiology, New York University Grossman School MedicineCenter for Biomedical Imaging, Department of Radiology, New York University Grossman School MedicineCenter for Biomedical Imaging, Department of Radiology, New York University Grossman School MedicineCentre for Advanced Imaging, The University of QueenslandCenter for Biomedical Imaging, Department of Radiology, New York University Grossman School MedicineAbstract Proton MRI can provide detailed morphological images, but it reveals little information about cell homeostasis. On the other hand, sodium MRI can provide metabolic information but cannot resolve fine structures. The complementary nature of proton and sodium MRI raises the prospect of their combined use in a single experiment. In this work, we assessed the repeatability of normalized proton density (PD), T1, T2, and normalized sodium density-weighted quantification measured with simultaneous 3D 1H MRF/23Na MRI in the brain at 7 T, from ten healthy volunteers who were scanned three times each. The coefficients of variation (CV) and the intra-class correlation (ICC) were calculated for the mean and standard deviation (SD) of these 4 parameters in grey matter, white matter, and cerebrospinal fluid. As result, the CVs were lower than 3.3% for the mean values and lower than 6.9% for the SD values. The ICCs were higher than 0.61 in all 24 measurements. We conclude that the measurements of normalized PD, T1, T2, and normalized sodium density-weighted from simultaneous 3D 1H MRF/23Na MRI in the brain at 7 T showed high repeatability. We estimate that changes > 6.6% (> 2 CVs) in mean values of both 1H and 23Na metrics could be detectable with this method.https://doi.org/10.1038/s41598-022-18388-1 |
| spellingShingle | Gonzalo G. Rodriguez Zidan Yu Lauren F. O′Donnell Liz Calderon Martijn A. Cloos Guillaume Madelin Repeatability of simultaneous 3D 1H MRF/23Na MRI in brain at 7 T Scientific Reports |
| title | Repeatability of simultaneous 3D 1H MRF/23Na MRI in brain at 7 T |
| title_full | Repeatability of simultaneous 3D 1H MRF/23Na MRI in brain at 7 T |
| title_fullStr | Repeatability of simultaneous 3D 1H MRF/23Na MRI in brain at 7 T |
| title_full_unstemmed | Repeatability of simultaneous 3D 1H MRF/23Na MRI in brain at 7 T |
| title_short | Repeatability of simultaneous 3D 1H MRF/23Na MRI in brain at 7 T |
| title_sort | repeatability of simultaneous 3d 1h mrf 23na mri in brain at 7 t |
| url | https://doi.org/10.1038/s41598-022-18388-1 |
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