Oral Submucous Fibrosis: Etiological Mechanism, Malignant Transformation, Therapeutic Approaches and Targets
Oral submucosal fibrosis (OSF) is a chronic, progressive and potentially malignant oral disorder with a high regional incidence and malignant rate. With the development of the disease, the normal oral function and social life of patients are seriously affected. This review mainly introduces the vari...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/5/4992 |
| _version_ | 1797615070948098048 |
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| author | Xiaofeng Qin Yujie Ning Liming Zhou Youming Zhu |
| author_facet | Xiaofeng Qin Yujie Ning Liming Zhou Youming Zhu |
| author_sort | Xiaofeng Qin |
| collection | DOAJ |
| description | Oral submucosal fibrosis (OSF) is a chronic, progressive and potentially malignant oral disorder with a high regional incidence and malignant rate. With the development of the disease, the normal oral function and social life of patients are seriously affected. This review mainly introduces the various pathogenic factors and mechanisms of OSF, the mechanism of malignant transformation into oral squamous cell carcinoma (OSCC), and the existing treatment methods and new therapeutic targets and drugs. This paper summarizes the key molecules in the pathogenic and malignant mechanism of OSF, the miRNAs and lncRNAs with abnormal changes, and the natural compounds with therapeutic effects, which provides new molecular targets and further research directions for the prevention and treatment of OSF. |
| first_indexed | 2024-03-11T07:21:17Z |
| format | Article |
| id | doaj.art-20f5bc6e00f344029c217e197997c1d1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T07:21:17Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-20f5bc6e00f344029c217e197997c1d12023-11-17T07:56:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01245499210.3390/ijms24054992Oral Submucous Fibrosis: Etiological Mechanism, Malignant Transformation, Therapeutic Approaches and TargetsXiaofeng Qin0Yujie Ning1Liming Zhou2Youming Zhu3Key Laboratory of Oral Diseases Research of Anhui Province, Department of Dental Implant Center, Stomatologic Hospital and College, Anhui Medical University, Hefei 230032, ChinaKey Laboratory of Oral Diseases Research of Anhui Province, Department of Dental Implant Center, Stomatologic Hospital and College, Anhui Medical University, Hefei 230032, ChinaKey Laboratory of Oral Diseases Research of Anhui Province, Department of Dental Implant Center, Stomatologic Hospital and College, Anhui Medical University, Hefei 230032, ChinaKey Laboratory of Oral Diseases Research of Anhui Province, Department of Dental Implant Center, Stomatologic Hospital and College, Anhui Medical University, Hefei 230032, ChinaOral submucosal fibrosis (OSF) is a chronic, progressive and potentially malignant oral disorder with a high regional incidence and malignant rate. With the development of the disease, the normal oral function and social life of patients are seriously affected. This review mainly introduces the various pathogenic factors and mechanisms of OSF, the mechanism of malignant transformation into oral squamous cell carcinoma (OSCC), and the existing treatment methods and new therapeutic targets and drugs. This paper summarizes the key molecules in the pathogenic and malignant mechanism of OSF, the miRNAs and lncRNAs with abnormal changes, and the natural compounds with therapeutic effects, which provides new molecular targets and further research directions for the prevention and treatment of OSF.https://www.mdpi.com/1422-0067/24/5/4992oral submucous fibrosisoral squamous cell carcinomamyofibroblastmalignant transformationepithelial–mesenchymal transitionnatural compounds |
| spellingShingle | Xiaofeng Qin Yujie Ning Liming Zhou Youming Zhu Oral Submucous Fibrosis: Etiological Mechanism, Malignant Transformation, Therapeutic Approaches and Targets International Journal of Molecular Sciences oral submucous fibrosis oral squamous cell carcinoma myofibroblast malignant transformation epithelial–mesenchymal transition natural compounds |
| title | Oral Submucous Fibrosis: Etiological Mechanism, Malignant Transformation, Therapeutic Approaches and Targets |
| title_full | Oral Submucous Fibrosis: Etiological Mechanism, Malignant Transformation, Therapeutic Approaches and Targets |
| title_fullStr | Oral Submucous Fibrosis: Etiological Mechanism, Malignant Transformation, Therapeutic Approaches and Targets |
| title_full_unstemmed | Oral Submucous Fibrosis: Etiological Mechanism, Malignant Transformation, Therapeutic Approaches and Targets |
| title_short | Oral Submucous Fibrosis: Etiological Mechanism, Malignant Transformation, Therapeutic Approaches and Targets |
| title_sort | oral submucous fibrosis etiological mechanism malignant transformation therapeutic approaches and targets |
| topic | oral submucous fibrosis oral squamous cell carcinoma myofibroblast malignant transformation epithelial–mesenchymal transition natural compounds |
| url | https://www.mdpi.com/1422-0067/24/5/4992 |
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