l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study
Many changes related to aging at the cellular level may be due to the physiological condition of mitochondria. One of the most common types of damage of mtDNA is the so-called “common deletion” referring to a deletion of 4977 base pairs. In the skin cells this phenomenon probably is caused by oxida...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-03-01
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| Series: | Cosmetics |
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| Online Access: | http://www.mdpi.com/2079-9284/1/1/51 |
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| author | Karolina Bazela Aleksandra Solyga-Zurek Renata Debowska Katarzyna Rogiewicz Ewa Bartnik Irena Eris |
| author_facet | Karolina Bazela Aleksandra Solyga-Zurek Renata Debowska Katarzyna Rogiewicz Ewa Bartnik Irena Eris |
| author_sort | Karolina Bazela |
| collection | DOAJ |
| description | Many changes related to aging at the cellular level may be due to the physiological condition of mitochondria. One of the most common types of damage of mtDNA is the so-called “common deletion” referring to a deletion of 4977 base pairs. In the skin cells this phenomenon probably is caused by oxidative damage of mtDNA induced by UV. The present study was aimed at evaluating the effect of the antioxidant l-ergothioneine on UV-induced damage in skin cells. The effect of l-ergothioneine on the reduced glutathione level was studied. The presence of the “common deletion” in human fibroblasts irradiated with UVA and treated with l-ergothioneine was evaluated by a polymerase chain reaction. We have demonstrated that l-ergothioneine enhanced the level of reduced glutathione and protected cells from the induction of a photoaging-associated mtDNA “common deletion”. In view of our results, l-ergothioneine could be an effective skin care and anti-photoaging ingredient. |
| first_indexed | 2024-12-12T22:10:20Z |
| format | Article |
| id | doaj.art-20f6388419dc4204a2229295018a0197 |
| institution | Directory Open Access Journal |
| issn | 2079-9284 |
| language | English |
| last_indexed | 2024-12-12T22:10:20Z |
| publishDate | 2014-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj.art-20f6388419dc4204a2229295018a01972022-12-22T00:10:16ZengMDPI AGCosmetics2079-92842014-03-0111516010.3390/cosmetics1010051cosmetics1010051l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary StudyKarolina Bazela0Aleksandra Solyga-Zurek1Renata Debowska2Katarzyna Rogiewicz3Ewa Bartnik4Irena Eris5Dr. Irena Eris Cosmetic Laboratories, Centre for Science and Research, Pulawska 107a, Warsaw 02-595, PolandInstitute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, Warsaw 02-106, PolandDr. Irena Eris Cosmetic Laboratories, Centre for Science and Research, Pulawska 107a, Warsaw 02-595, PolandDr. Irena Eris Cosmetic Laboratories, Centre for Science and Research, Pulawska 107a, Warsaw 02-595, PolandInstitute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, Warsaw 02-106, PolandDr. Irena Eris Cosmetic Laboratories, Centre for Science and Research, Pulawska 107a, Warsaw 02-595, PolandMany changes related to aging at the cellular level may be due to the physiological condition of mitochondria. One of the most common types of damage of mtDNA is the so-called “common deletion” referring to a deletion of 4977 base pairs. In the skin cells this phenomenon probably is caused by oxidative damage of mtDNA induced by UV. The present study was aimed at evaluating the effect of the antioxidant l-ergothioneine on UV-induced damage in skin cells. The effect of l-ergothioneine on the reduced glutathione level was studied. The presence of the “common deletion” in human fibroblasts irradiated with UVA and treated with l-ergothioneine was evaluated by a polymerase chain reaction. We have demonstrated that l-ergothioneine enhanced the level of reduced glutathione and protected cells from the induction of a photoaging-associated mtDNA “common deletion”. In view of our results, l-ergothioneine could be an effective skin care and anti-photoaging ingredient.http://www.mdpi.com/2079-9284/1/1/51l-ergothioneinecommon deletionmitochondriaphotoaging |
| spellingShingle | Karolina Bazela Aleksandra Solyga-Zurek Renata Debowska Katarzyna Rogiewicz Ewa Bartnik Irena Eris l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study Cosmetics l-ergothioneine common deletion mitochondria photoaging |
| title | l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study |
| title_full | l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study |
| title_fullStr | l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study |
| title_full_unstemmed | l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study |
| title_short | l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study |
| title_sort | l ergothioneine protects skin cells against uv induced damage a preliminary study |
| topic | l-ergothioneine common deletion mitochondria photoaging |
| url | http://www.mdpi.com/2079-9284/1/1/51 |
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