Effects of sugammadex versus neostigmine on postoperative nausea and vomiting after general anesthesia in adult patients:a single-center retrospective study
Abstract We aimed to compare the effect of sugammadex to that of neostigmine with respect to the occurrence of postoperative nausea and vomiting (PONV) during the first 24 h following general anesthesia. This retrospective cohort study included patients who underwent elective surgery under general a...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-32730-1 |
| _version_ | 1797850082476818432 |
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| author | Jae-Woo Ju In Eob Hwang Hye-Yeon Cho Seong Mi Yang Won Ho Kim Ho-Jin Lee |
| author_facet | Jae-Woo Ju In Eob Hwang Hye-Yeon Cho Seong Mi Yang Won Ho Kim Ho-Jin Lee |
| author_sort | Jae-Woo Ju |
| collection | DOAJ |
| description | Abstract We aimed to compare the effect of sugammadex to that of neostigmine with respect to the occurrence of postoperative nausea and vomiting (PONV) during the first 24 h following general anesthesia. This retrospective cohort study included patients who underwent elective surgery under general anesthesia in 2020 at an academic medical center in Seoul, South Korea. The exposure groups were determined according to whether the patient received sugammadex or neostigmine as a reversal agent. The primary outcome was PONV occurrence during the first 24 h postoperatively (overall). The association between the type of reversal agent and primary outcome was investigated using logistic regression while adjusting for confounding variables using stabilized inverse probability of treatment weighting (sIPTW). Of the 10,912 patients included in this study, 5,918 (54.2%) received sugammadex. Sugammadex was associated with a significantly lower incidence of overall PONV (15.8% vs. 17.7%; odds ratio, 0.87; 95% confidence interval [CI], 0.79–0.97; P = 0.010) after sIPTW. In conclusion, compared with neostigmine/glycopyrrolate, sugammadex use has a lower risk of PONV during the first 24 h following general anesthesia. |
| first_indexed | 2024-04-09T18:55:41Z |
| format | Article |
| id | doaj.art-20f6c3a6b23f49b88a93d1c4dda02ae6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T18:55:41Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-20f6c3a6b23f49b88a93d1c4dda02ae62023-04-09T11:12:51ZengNature PortfolioScientific Reports2045-23222023-04-011311810.1038/s41598-023-32730-1Effects of sugammadex versus neostigmine on postoperative nausea and vomiting after general anesthesia in adult patients:a single-center retrospective studyJae-Woo Ju0In Eob Hwang1Hye-Yeon Cho2Seong Mi Yang3Won Ho Kim4Ho-Jin Lee5Department of Anesthesiology and Pain Medicine, Seoul National University HospitalDepartment of Anesthesiology and Pain Medicine, Seoul National University HospitalDepartment of Anesthesiology and Pain Medicine, Seoul National University College of MedicineDepartment of Anesthesiology and Pain Medicine, Asan Medical CenterDepartment of Anesthesiology and Pain Medicine, Seoul National University HospitalDepartment of Anesthesiology and Pain Medicine, Seoul National University HospitalAbstract We aimed to compare the effect of sugammadex to that of neostigmine with respect to the occurrence of postoperative nausea and vomiting (PONV) during the first 24 h following general anesthesia. This retrospective cohort study included patients who underwent elective surgery under general anesthesia in 2020 at an academic medical center in Seoul, South Korea. The exposure groups were determined according to whether the patient received sugammadex or neostigmine as a reversal agent. The primary outcome was PONV occurrence during the first 24 h postoperatively (overall). The association between the type of reversal agent and primary outcome was investigated using logistic regression while adjusting for confounding variables using stabilized inverse probability of treatment weighting (sIPTW). Of the 10,912 patients included in this study, 5,918 (54.2%) received sugammadex. Sugammadex was associated with a significantly lower incidence of overall PONV (15.8% vs. 17.7%; odds ratio, 0.87; 95% confidence interval [CI], 0.79–0.97; P = 0.010) after sIPTW. In conclusion, compared with neostigmine/glycopyrrolate, sugammadex use has a lower risk of PONV during the first 24 h following general anesthesia.https://doi.org/10.1038/s41598-023-32730-1 |
| spellingShingle | Jae-Woo Ju In Eob Hwang Hye-Yeon Cho Seong Mi Yang Won Ho Kim Ho-Jin Lee Effects of sugammadex versus neostigmine on postoperative nausea and vomiting after general anesthesia in adult patients:a single-center retrospective study Scientific Reports |
| title | Effects of sugammadex versus neostigmine on postoperative nausea and vomiting after general anesthesia in adult patients:a single-center retrospective study |
| title_full | Effects of sugammadex versus neostigmine on postoperative nausea and vomiting after general anesthesia in adult patients:a single-center retrospective study |
| title_fullStr | Effects of sugammadex versus neostigmine on postoperative nausea and vomiting after general anesthesia in adult patients:a single-center retrospective study |
| title_full_unstemmed | Effects of sugammadex versus neostigmine on postoperative nausea and vomiting after general anesthesia in adult patients:a single-center retrospective study |
| title_short | Effects of sugammadex versus neostigmine on postoperative nausea and vomiting after general anesthesia in adult patients:a single-center retrospective study |
| title_sort | effects of sugammadex versus neostigmine on postoperative nausea and vomiting after general anesthesia in adult patients a single center retrospective study |
| url | https://doi.org/10.1038/s41598-023-32730-1 |
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