Concurrent photoacoustic and ultrasound microscopy with a coaxial dual-element ultrasonic transducer
Abstract Simultaneous photoacoustic and ultrasound (PAUS) imaging has attracted increasing attention in biomedical research to probe the optical and mechanical properties of tissue. However, the resolution for majority of the existing PAUS systems is on the order of 1 mm as the majority are designed...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-09-01
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| Series: | Visual Computing for Industry, Biomedicine, and Art |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s42492-018-0003-4 |
| _version_ | 1819002869760655360 |
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| author | Yuqi Tang Wei Liu Yang Li Qifa Zhou Junjie Yao |
| author_facet | Yuqi Tang Wei Liu Yang Li Qifa Zhou Junjie Yao |
| author_sort | Yuqi Tang |
| collection | DOAJ |
| description | Abstract Simultaneous photoacoustic and ultrasound (PAUS) imaging has attracted increasing attention in biomedical research to probe the optical and mechanical properties of tissue. However, the resolution for majority of the existing PAUS systems is on the order of 1 mm as the majority are designed for clinical use with low-frequency US detection. Here we developed a concurrent PAUS microscopy that consists of optical-resolution photoacoustic microscopy (OR-PAM) and high-frequency US pulse-echo imaging. This dual-modality system utilizes a novel coaxial dual-element ultrasonic transducer (DE-UST) and provides anatomical and functional information with complementary contrast mechanisms, achieving a spatial resolution of 7 μm for PA imaging and 106 μm for US imaging. We performed phantom studies to validate the system’s performance. The vasculature of a mouse’s hind paw was imaged to demonstrate the potential of this hybrid system for biomedical applications. |
| first_indexed | 2024-12-20T23:11:58Z |
| format | Article |
| id | doaj.art-20f71c246cf84946a84cfb058ca46c85 |
| institution | Directory Open Access Journal |
| issn | 2524-4442 |
| language | English |
| last_indexed | 2024-12-20T23:11:58Z |
| publishDate | 2018-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Visual Computing for Industry, Biomedicine, and Art |
| spelling | doaj.art-20f71c246cf84946a84cfb058ca46c852022-12-21T19:23:43ZengSpringerOpenVisual Computing for Industry, Biomedicine, and Art2524-44422018-09-01111610.1186/s42492-018-0003-4Concurrent photoacoustic and ultrasound microscopy with a coaxial dual-element ultrasonic transducerYuqi Tang0Wei Liu1Yang Li2Qifa Zhou3Junjie Yao4Department of Biomedical Engineering, Duke UniversityDepartment of Biomedical Engineering, Duke UniversityDepartment of Ophthalmology, Department of Biomedical Engineering, University of Southern CaliforniaDepartment of Ophthalmology, Department of Biomedical Engineering, University of Southern CaliforniaDepartment of Biomedical Engineering, Duke UniversityAbstract Simultaneous photoacoustic and ultrasound (PAUS) imaging has attracted increasing attention in biomedical research to probe the optical and mechanical properties of tissue. However, the resolution for majority of the existing PAUS systems is on the order of 1 mm as the majority are designed for clinical use with low-frequency US detection. Here we developed a concurrent PAUS microscopy that consists of optical-resolution photoacoustic microscopy (OR-PAM) and high-frequency US pulse-echo imaging. This dual-modality system utilizes a novel coaxial dual-element ultrasonic transducer (DE-UST) and provides anatomical and functional information with complementary contrast mechanisms, achieving a spatial resolution of 7 μm for PA imaging and 106 μm for US imaging. We performed phantom studies to validate the system’s performance. The vasculature of a mouse’s hind paw was imaged to demonstrate the potential of this hybrid system for biomedical applications.http://link.springer.com/article/10.1186/s42492-018-0003-4Photoacoustic microscopyUltrasound microscopyConcurrent imagingCoaxial dual-element ultrasonic transducer |
| spellingShingle | Yuqi Tang Wei Liu Yang Li Qifa Zhou Junjie Yao Concurrent photoacoustic and ultrasound microscopy with a coaxial dual-element ultrasonic transducer Visual Computing for Industry, Biomedicine, and Art Photoacoustic microscopy Ultrasound microscopy Concurrent imaging Coaxial dual-element ultrasonic transducer |
| title | Concurrent photoacoustic and ultrasound microscopy with a coaxial dual-element ultrasonic transducer |
| title_full | Concurrent photoacoustic and ultrasound microscopy with a coaxial dual-element ultrasonic transducer |
| title_fullStr | Concurrent photoacoustic and ultrasound microscopy with a coaxial dual-element ultrasonic transducer |
| title_full_unstemmed | Concurrent photoacoustic and ultrasound microscopy with a coaxial dual-element ultrasonic transducer |
| title_short | Concurrent photoacoustic and ultrasound microscopy with a coaxial dual-element ultrasonic transducer |
| title_sort | concurrent photoacoustic and ultrasound microscopy with a coaxial dual element ultrasonic transducer |
| topic | Photoacoustic microscopy Ultrasound microscopy Concurrent imaging Coaxial dual-element ultrasonic transducer |
| url | http://link.springer.com/article/10.1186/s42492-018-0003-4 |
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