The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma
Abstract Aldosterone reductase family 1 member B10 (AKR1B10) is a nicotinamide adenine dinucleotide phosphate (reduced coenzyme II)-dependent oxidoreductase, and its biological functions include carbonyl detoxification, hormone metabolism, osmotic adjustment, and lipid synthesis. Studies suggested t...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-97648-y |
| _version_ | 1818856281243385856 |
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| author | Jixuan Liu Hongyan Ban Yafang Liu Jinsong Ni |
| author_facet | Jixuan Liu Hongyan Ban Yafang Liu Jinsong Ni |
| author_sort | Jixuan Liu |
| collection | DOAJ |
| description | Abstract Aldosterone reductase family 1 member B10 (AKR1B10) is a nicotinamide adenine dinucleotide phosphate (reduced coenzyme II)-dependent oxidoreductase, and its biological functions include carbonyl detoxification, hormone metabolism, osmotic adjustment, and lipid synthesis. Studies suggested that AKR1B10 is a new biomarker for cancer based on its overexpression in epithelial tumors, such as breast cancer, cervical cancer, and lung cancer. At present, studies on the expression of AKR1B10 in laryngeal cancer have not been reported. However, we found that AKR1B10 is upregulated in laryngeal carcinoma, and its expression was negatively correlated with the degree of differentiation. In addition, AKR1B10 expression was positively correlated with tumor size; lymph node metastasis; alcohol use; and Ki-67, mutant p53, and matrix metalloproteinase 2 expression. AKR1B10 was overexpressed in Hep-2 laryngeal carcinoma cells. Oleanolic acid inhibited AKR1B10 activity and expression in Hep-2 cells and suppressed Hep-2 cell proliferation, migration, and invasion. Therefore, AKR1B10 may be related to the development of laryngeal carcinoma, suggesting its use as a prognostic indicator for laryngeal cancer. |
| first_indexed | 2024-12-19T08:22:00Z |
| format | Article |
| id | doaj.art-20f86582db934b19bd95885ae261cb53 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T08:22:00Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-20f86582db934b19bd95885ae261cb532022-12-21T20:29:22ZengNature PortfolioScientific Reports2045-23222021-09-0111111210.1038/s41598-021-97648-yThe expression and significance of AKR1B10 in laryngeal squamous cell carcinomaJixuan Liu0Hongyan Ban1Yafang Liu2Jinsong Ni3Department of Pathology, The First Hospital of Jilin UniversityDepartment of Pathology, Maternal and Child Health Hospital of Jilin ProvinceDepartment of Pathology, The First Hospital of Jilin UniversityDepartment of Pathology, The First Hospital of Jilin UniversityAbstract Aldosterone reductase family 1 member B10 (AKR1B10) is a nicotinamide adenine dinucleotide phosphate (reduced coenzyme II)-dependent oxidoreductase, and its biological functions include carbonyl detoxification, hormone metabolism, osmotic adjustment, and lipid synthesis. Studies suggested that AKR1B10 is a new biomarker for cancer based on its overexpression in epithelial tumors, such as breast cancer, cervical cancer, and lung cancer. At present, studies on the expression of AKR1B10 in laryngeal cancer have not been reported. However, we found that AKR1B10 is upregulated in laryngeal carcinoma, and its expression was negatively correlated with the degree of differentiation. In addition, AKR1B10 expression was positively correlated with tumor size; lymph node metastasis; alcohol use; and Ki-67, mutant p53, and matrix metalloproteinase 2 expression. AKR1B10 was overexpressed in Hep-2 laryngeal carcinoma cells. Oleanolic acid inhibited AKR1B10 activity and expression in Hep-2 cells and suppressed Hep-2 cell proliferation, migration, and invasion. Therefore, AKR1B10 may be related to the development of laryngeal carcinoma, suggesting its use as a prognostic indicator for laryngeal cancer.https://doi.org/10.1038/s41598-021-97648-y |
| spellingShingle | Jixuan Liu Hongyan Ban Yafang Liu Jinsong Ni The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma Scientific Reports |
| title | The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma |
| title_full | The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma |
| title_fullStr | The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma |
| title_full_unstemmed | The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma |
| title_short | The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma |
| title_sort | expression and significance of akr1b10 in laryngeal squamous cell carcinoma |
| url | https://doi.org/10.1038/s41598-021-97648-y |
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